keangkong
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Semaglutide 7.2mg achieved 20.7% weight loss in STEP UP obesity trial
- Thread starter keangkong
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Nobody could eat because they were napping all day. I tried sema 7.2 and was fricking exhausted.
From the study: "experienced weight loss of 20.7% after 72 weeks, compared to 17.5% in the semaglutide 2.4 mg cohort." So, tripling the dose achieved a 3% increase. I think they have hit the point of diminishing returns. I can't imagine what the side effects would be for that small of an increase. This seems to be a battle for market share. Cagrisema will match tirzepatide, not beat it. Retatrutide and Evil Lilly will be king when it comes out. Semaglutide will be 3rd tier.
Keeping in mind, they all have other things they work on, too. If you're looking at JUST weight loss, tirz and reta. If you have fatty liver, reta or cagrisema or survo. If you have heart issues, no reta. Sema or cagrisema best for SUD or AUD or BED, and I think I remember sema being best for cognitive decline, as well.
I think they're all going to be useful in different ways.
McFatty
New_Member
I was kn 2.4mg and I stalled for months. I had horrible heart burn and felt weird after taking the shot. Switched to tirz, no side effects and weight loss at 7.5 every 5 days. I can't fathom what 7.2 would do to me.
I been considering reta.
Regarding heart issues, I'm coming up with stats that suggest around 6% of participants have heart issues, can anyone confirm or know of more recent studies? (for example: https://www.nejm.org/doi/full/10.1056/NEJMoa2301972#fv-t3fn2)
Table 1 in that article, shows 30-40% of all reta groups with hypertension. Not sure what you call heart issues particularly.
Table 3 I ckudes adverse effects but doesn't call out increased heart rate, so it wasn't severe I guess. Arrhythmia is very low.
