Semaglutide linked to vision loss risk

[clayd]

Up to 1 in 200 patients may develop optic nerve damage over 20 years of use. 0.5%

Seems like the optic nerve damage is permanent but doesn't happen to both eyes from what I see here.

Only sema studied so far

https://www.gbnews.com/health/ozempic-linked-rare-irreversible-vision-loss-large-scale-trial

 

[YoYoFat]

Who’s been using Sema for 20 years?

 

[clayd]

They are suggesting that would be the incidence rate based on studying existing patient-years

 

[YoYoFat]

Diabetics are prone to vision loss. Sema was originally branded as Ozempic, meant for diabetics.

 

[raw_oyster_eater]

Who’s been using Sema for 20 years?

they're extrapolating.

 

[christy0110]

My vision in one eye has become worse in last 5 months but could be completely coincidental

 

[clayd]

My vision in one eye has become worse in last 5 months but could be completely coincidental

You should get it checked, you can take something other than sema if needed

 

[keangkong]

My vision in both eyes is terrible. This started about 40 years ago.

 

[penewbie]

incidence rate difference (absolute risk increase) was +1.41 NAION events per 10,000 person-years.

Yea, I'd take that risk.

 

[AndyPanda]

You should get it checked, you can take something other than sema if needed

It’s listed as a side effect of Tirzapatide/Mounjaro as well. This has had me a bit freaked out.

 

[YoYoFat]

they're extrapolating.

That’s not how legit studies are run.

 

[raw_oyster_eater]

That’s not how legit studies are run.

agreed, i was just telling everyone what they were doing.

 

[brentm]

That’s not how legit studies are run.

But it makes for such great news headlines!

 

[exploitedworkerbee]

I can’t be the only one waiting for the other shoe to drop on our beloved wonder drugs right? Honestly if it turns out to be 1 in 200 of us long term users go blind in one eye, that’s way better than whatever terrible cancers or other ailments we could have been giving ourselves. I’ll take it!

 

[GLP69]

pick your poison I guess. a tiny chance of becoming a little bit blind by the time I'm retired is probably better than being overweight and dying of a heart attack by the same point.

 

[TTRich]

Up to 1 in 200 patients may develop optic nerve damage over 20 years of use. 0.5%

Seems like the optic nerve damage is permanent but doesn't happen to both eyes from what I see here.

Only sema studied so far

https://www.gbnews.com/health/ozempic-linked-rare-irreversible-vision-loss-large-scale-trial

I don't know, this study seems kind of unscientific. How can they presume what happens in 20 years that 1 person out of 200 will go blind in one eye from sema? I presume in 20 years of suffering from diabetes at least 1 person will go blind in both eyes from not using sema. I'm a tennis pro not a scientist.

 

[clayd]

I don't know, this study seems kind of unscientific. How can they presume what happens in 20 years that 1 person out of 200 will go blind in one eye from sema? I presume in 20 years of suffering from diabetes at least 1 person will go blind in both eyes from not using sema. I'm a tennis pro not a scientist.

It is a recognized method of doing papers

You can decide if it's a good method of doing science

 

[AndyPanda]

They used to tell young men that other things would make us go blind. None of that came to fruition either.

 

[Deeubee]

Up to 1 in 200 patients may develop optic nerve damage over 20 years of use. 0.5%

Seems like the optic nerve damage is permanent but doesn't happen to both eyes from what I see here.

Only sema studied so far

https://www.gbnews.com/health/ozempic-linked-rare-irreversible-vision-loss-large-scale-trial

It's been addressed. Let me find the video

 

[Deeubee]

 

[penewbie]

This is the most boring youtube I have ever seen.

Basically only relevant if you're a statistician/doctor interested in running similar studies, you'll benefit from this video.
They hardly even talk about the study itself.

 

[afrayy]

They used to tell young men that other things would make us go blind. None of that came to fruition either.

I don't know Andy, im in my 40s and have been steadily going blind since my teens 😉

No hair on my palms though!

 

[Deeubee]

This is the most boring youtube I have ever seen.

Basically only relevant if you're a statistician/doctor interested in running similar studies, you'll benefit from this video.
They hardly even talk about the study itself.

The Devil is in the details innit? Well they mentioned not having details to the patient charts themselves, but highlight how statistical bias may contribute to result findings. It's not like the original researchers themselves addressed whether this is a Semaglutide alone issue or a GlP-1 issue, and also whether this was diabetes related vs Sema in obesity alone.