SLU-PP-332 as a Workout Replacement

[hexagonal]

I'm pretty skeptical on slu-pp-332. Lots of talk on meso about people taking stuff in the 50-250mg/day range and not seeing much of anything from it, buying the 10g raws from SSA.

Type-IIx talked about it a bit on his latest podcast, from his reading of the little research there is, seems like the mechanistically provable benefits even in rats would translate more to help for endurance athletes than anything else.

Couple that with a totally unknown safety profile in humans, and I'd recommend skipping it, personally.

 

[AndyPanda]

I think Clenbuterol and AICAR both work better than SLU. I often wonder how it has gained so much attention on the forums. I do Jiu Jitsu twice a week and the aforementioned have helped me keep up with people half my age.

 

[Someguy22922]

I think Clenbuterol and AICAR both work better than SLU. I often wonder how it has gained so much attention on the forums. I do Jiu Jitsu twice a week and the aforementioned have helped me keep up with people half my age.

Clen is awesome! Some people get horrible sides though, personally I love the stuff.

 

[AndyPanda]

Clen is awesome! Some people get horrible sides though, personally I love the stuff.

It is a miracle. I take 40mcg and it would be too much if I were just sitting around.

 

[Someguy22922]

It is a miracle. I take 40mcg and it would be too much if I were just sitting around.

Do you take taurine with it / get cramps at all? That and shaking like crazy when I first start are about the only sides I get.

 

[hexagonal]

I think Clenbuterol and AICAR both work better than SLU. I often wonder how it has gained so much attention on the forums. I do Jiu Jitsu twice a week and the aforementioned have helped me keep up with people half my age.

There's a lot of youtube influencers pushing it, particularly in the PED space, which has bled over into the peptide space.

A lot of said influencers have affiliate setups with aminos asylum, modern aminos, etc., so they have financial incentive, too.

Doesn't mean it doesn't work, of course.

 

[Someguy22922]

There's a lot of youtube influencers pushing it, particularly in the PED space, which has bled over into the peptide space.

A lot of said influencers have affiliate setups with aminos asylum, modern aminos, etc., so they have financial incentive, too.

Doesn't mean it doesn't work, of course.

I agree. Usually discount codes worm by giving them a kickback equivalent to the discount.

Like most PEDs, it seems down to genetics. One guy can blow up on 300 test, another gets nothing out of a gram etc...

My biggest issue with slu is the general retail price is absurd.

 

[AndyPanda]

Do you take taurine with it / get cramps at all? That and shaking like crazy when I first start are about the only sides I get.

I do not take taurine. I typically run on pure anxiety and the Clen gives me mental clarity like crazy. If I’m active I don’t get the shakes. It hits me at about 30 minutes and lasts about three hours. It gives me less sides than adderral does.

 

[hexagonal]

I agree. Usually discount codes worm by giving them a kickback equivalent to the discount.

Like most PEDs, it seems down to genetics. One guy can blow up on 300 test, another gets nothing out of a gram etc...

My biggest issue with slu is the general retail price is absurd.

Yep. SSA raws seem to be the only economical option I've seen.

 

[TetsuNW]

I'll try my best to address your list.

A) if you aren't on point, don't take drugs that may or may not have health risks.
B) the leaner you are, the harder fat loss is. Less insulin sensitivity benefits. I've seen less results in lean individuals
C) again, if you are going to use drugs, you should prob be doing some sort of resistance exercise.
D) the clients ranged from a woman trying to lose weight for her bday, 55 year old trt bro, competitive bodybuilders. Despite what I said about A and C, I tend to see better results in those who are untrained and not on a structured diet. There is just so much room for them to improve. I just don't think drugs are a long term solution. Some basic dieting principles and drugs, sure, I am fine with that.

Do you have much experience with PEDs? The genetic variation from person to person is mind blowing. I for example, can run 750 mgs of test E a week with 0 AI, other need lots on 150 mgs a week. Nandrolone makes me insanely depressed and limp dicked. Not the same for everyone. I can handle my tren. Others become massive assholes. Slu is no different than any other PED in this aspect. My best advice is, buy a small amount, and try it yourself.

If I had to fathom some sort of educated/ scientific guess why slu works for some and not others would be due to a lower density of estrogen receptors. It is an estrogen related receptor agonist after all.

Of course I was on other drugs during prep. There are two types of competitive bodybuilders. Ones who compete in untested competitions, and liars.

Tren, clen, mast, reta were all constant from week 12 on.

My show was Oct 27th. I am currently 202 lbs. 5 foot 8.5, prob 12-14% bodyfat.

Nice info. I agree with all of that. No sense and taking risks if everything isn't already optimized.

I dont have much personal experience with PEDs. Only PH back in the day, andro, pheraplex, halo, some serm/sarm and a bunch of clen, eca, and dmaa lol. Started messing with peptides on and off some 20yr ago too, igf-1-lr3, peg-mgf, cjc, m2, then later bpc, TB500, pt141,a few other things mixed in basically geared towards some sort of injury recovery/health outcome.

Your guess about estrogen makes sense to me. I'd for sure need to get labs before I tried slu-pp-332.

 

[jimbothigpen]

I'm pretty skeptical on slu-pp-332. Lots of talk on meso about people taking stuff in the 50-250mg/day range and not seeing much of anything from it, buying the 10g raws from SSA.

I'm completely ignorant of what goes on over in those body builder forums, so I'm not sure what the expectations are, or what their methodologies are for evaluating efficacy. If folks are expecting an immediate physiological response to the drug, they may very well be disappointed -- in my very limited (5 days) experience with the drug, the only feelz I get from it are 1) a brief (1 or 2 hour) interruption of the GLP-1 chills I experience from tirz/reta, 2) increased perspiration during physical activity, and 3) a sense (not quantifiable, exactly) that exercise is easier. My personal interest is in the potential longer term exercise mimetic properties, the evaluation of which requires a lot more than "took some, didn't feel shit." @Someguy22922 has some actual numbers there, along with what appears to be a clientele that responds positively to the drug in measurable ways.

My current plans are to continue to titrate up from 1mg, 2 x daily to 100mg, 2 x daily, and continue at that level until the stash runs out -- which should be about 2 months total, give or take -- taking body measurements along the way, without introducing any other changes. I'm a mid-50s fat guy, down from 242# to 213# over 39 days so far on 2.5mg each of tirz & reta every 5 days. If I can reverse, halt, or slow down the muscle loss I'm certain has occurred over the past month, without introducing resistance training, I'll consider this a success. I certainly hope it'll work -- but if not I don't mind learning how to work the weight machines & building it back on if necessary.

 

[raw_oyster_eater]

so the problem i have is we have a guy right here, someguy who is extremely experienced. i mean just look at his picture. who is telling us 2 250 mcg pills a day worked for him.

there may be some difference between a finished pill and pouring raws into a capsule. I don't know.. i'm just questioning. when i take 3 190 pills i definitely feel something and got a bit of a headache to start.

using those raws to make injectable would be interesting.

 

[Someguy22922]

so the problem i have is we have a guy right here, someguy who is extremely experienced. i mean just look at his picture. who is telling us 2 250 mcg pills a day worked for him.

there may be some difference between a finished pill and pouring raws into a capsule. I don't know.. i'm just questioning. when i take 3 190 pills i definitely feel something and got a bit of a headache to start.

using those raws to make injectable would be interesting.

The fillers added to caps or tabs don't make a huge difference to the final product.

It's usually raws and creatine (of done by a stupid lab), or raws and mannitol (alright), raws and microcrystallinne cellulose (also alright), or raws + mannitol + cromcarmellose sodium.

The last combo is usually the best, but only for formulations that absorb poorly. Mannitol slows down absorption, but doesn't degrade the raw at all nor decrease bioavailability like cellulose, and the crocarmellose offsets the mannitol slowed down absorption. Cromcarmellose takes on a ton of water increasing the surface area of a tab / dissolved cap in your stomach increasing absorption.

Does most of this matter? I doubt it unless you are selling and want to have an edge on your competition for certain compounds that don't absorb well.

 

[hexagonal]

I'm completely ignorant of what goes on over in those body builder forums, so I'm not sure what the expectations are, or what their methodologies are for evaluating efficacy. If folks are expecting an immediate physiological response to the drug, they may very well be disappointed -- in my very limited (5 days) experience with the drug, the only feelz I get from it are 1) a brief (1 or 2 hour) interruption of the GLP-1 chills I experience from tirz/reta, 2) increased perspiration during physical activity, and 3) a sense (not quantifiable, exactly) that exercise is easier. My personal interest is in the potential longer term exercise mimetic properties, the evaluation of which requires a lot more than "took some, didn't feel shit." @Someguy22922 has some actual numbers there, along with what appears to be a clientele that responds positively to the drug in measurable ways.

My current plans are to continue to titrate up from 1mg, 2 x daily to 100mg, 2 x daily, and continue at that level until the stash runs out -- which should be about 2 months total, give or take -- taking body measurements along the way, without introducing any other changes. I'm a mid-50s fat guy, down from 242# to 213# over 39 days so far on 2.5mg each of tirz & reta every 5 days. If I can reverse, halt, or slow down the muscle loss I'm certain has occurred over the past month, without introducing resistance training, I'll consider this a success. I certainly hope it'll work -- but if not I don't mind learning how to work the weight machines & building it back on if necessary.

They're generally looking for assistance with cutting or cardio, since the mechanistic evidence seems to be that those are the areas where it might realistically help. Some of them have given it time and taken it over weeks/months based on their posts, so at the very least they're claiming to have given it time to see an impact.

I would say that I would not expect it to do anything for muscle loss even if it does work in humans at anything near the efficacy we've seen in rodent studies. It just doesn't work on the right receptors or with any other mechanisms that would help there. There have been some exercise mimetics that showed promise there, like azalaprag, but the trials for it were halted due to elevated liver values.

 

[hexagonal]

so the problem i have is we have a guy right here, someguy who is extremely experienced. i mean just look at his picture. who is telling us 2 250 mcg pills a day worked for him.

there may be some difference between a finished pill and pouring raws into a capsule. I don't know.. i'm just questioning. when i take 3 190 pills i definitely feel something and got a bit of a headache to start.

using those raws to make injectable would be interesting.

Lots of people swear by all sorts of things that don't work better than placebo when studied at scale. Humans are really susceptible to suggestion, even ones that have a lot of experience with special sports supplements.

Which isn't to say it isn't working for him, and perhaps he's right that there are genetic differences that matter for how effective it is. But anecdotal reports of forum users also aren't enough to meet scientific standards for a reason, too.

If we had any idea about the safety concerns for usage in humans I'd figure it's fine to try it and see if it works for you, or if you think it does. I've spent all sorts of money on things that are of dubious value. But for all we know this could be as dangerous as cardarine and with less proven benefits

 

[Vicki]

They use injectable in studies because oral had poor bio availability. They didn't really elaborate on numbers sadly.

If you have brewed AAS, or currently brew, it's not much of a different process minus the solvents required. If you increase the organic solvent %, you can get it to hold at much higher MG / ML.

I assumed they used injectable because the rats wouldn't eat it? What study did you see?

 

[raw_oyster_eater]

But for all we know this could be as dangerous as cardarine and with less proven benefits

you could expand on that further and say you should't be doing any of this. everybody has their own line. sorry we crossed yours. wait. not sorry.

 

[Someguy22922]

I assumed they used injectable because the rats wouldn't eat it? What study did you see?

A Synthetic ERR Agonist Alleviates Metabolic Syndrome - PMC

Physical exercise induces physiologic adaptations and is effective at reducing the risk of premature death from all causes. Pharmacological exercise mimetics may be effective in the treatment of a range of diseases including obesity and metabolic ...

pmc.ncbi.nlm.nih.gov

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity - PMC

Repetitive physical exercise induces physiological adaptations in skeletal muscle that improves exercise performance and is effective for the prevention and treatment of several diseases. Genetic evidence indicates that the orphan nuclear receptors ...

pmc.ncbi.nlm.nih.gov

Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

Cardiac metabolic dysfunction is a hallmark of heart failure. Estrogen related receptors ERRα and ERRγ are essential regulators for cardiac metabolism. Therefore, activation of ERR could be a potential therapeutic intervention for heart failure. However, no natural or synthetic ERR agonist is...

www.biorxiv.org

All only used injectable.

 

[Vicki]

Do they mention it doesn't work well orally? I see mostly pills or raws. Ive seen a few vendors selling in vials but people complained they can't even reconstitute it.

It might also work sublingual I'm guessing based on molecular size too. That's what I was planning to try

 

[Someguy22922]

Do they mention it doesn't work well orally? I see mostly pills or raws. Ive seen a few vendors selling in vials but people complained they can't even reconstitute it.

It might also work sublingual I'm guessing based on molecular size too. That's what I was planning to try

Typically companies try to avoid injections during to piss poor patient compliance. I didn't see anything on oral bioavailability anywhere, but I didn't scan deeply for it. They don't even mention trying an oral suspension or pill.

Working on freeze drying it now. I think to reconstitute you, one would need to provide a specific reconstituion liquid.