SLU-PP 332 sources & feedback

I have used it from umbrella labs, kimerachems, and nexaph. Nexaph I have as capsules. The others I used as a liquid. I use 250 mcg 2x/day from kimerachems and I think it has helped me with exercise as well as weight management/loss.

-G
 
gershon said:
I have used it from umbrella labs, kimerachems, and nexaph. Nexaph I have as capsules. The others I used as a liquid. I use 250 mcg 2x/day from kimerachems and I think it has helped me with exercise as well as weight management/loss.

-G
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(Pointless aside: how do folks order from umbrella labs and *not* think they’re going to be zombie-fied? The logo is basically the same, the font is just about the same, couldn’t be me 😂 that is all, sorry for the intrusion, carry on.)
 
Not to mother anyone, but I am curious about the willingness to take something that has not yet had any human trials - we only have minimal results in animal trials, so lack of data around efficacy in humans combined with having no clue whether or not it is safe to use in humans makes me fairly wary.

How are you calculating the risk vs. reward here? What level of impact makes it worth the unknown level of risk?
 
hexagonal said:
Not to mother anyone, but I am curious about the willingness to take something that has not yet had any human trials - we only have minimal results in animal trials, so lack of data around efficacy in humans combined with having no clue whether or not it is safe to use in humans makes me fairly wary.

How are you calculating the risk vs. reward here? What level of impact makes it worth the unknown level of risk?
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I think people that willing came to the grey/black market, as opposed to being “forced” (it’s all 100% voluntary) here by EL & the fda, tend to be bigger experimenters. You read the literature (or skim enough of it) and you’re good to go. You know your body, and chances are you’ve done this many times before with many other substances. Does it always go the way you want? No, but you learn and keep it moving.

The people who have been “pushed” to this side probably don’t have the same devil may care, imma try this attitude. You can read through this forum, tg, discord, reddit, etc. and see that. They want more guarantees, more assurances, safety nets. There’s nothing wrong with that bc you’re injecting shit into your body, but that’s not how the first set rolls.
 
Makes sense. It's just a bit surprising to me - I consider myself pretty daredevilish (or dumb) when it comes to putting things in my body - I've tried basically every recreational drug short of fentanyl and the other super-opioids, I've got 8 peptides on my slate, and the thought of doing moderate amounts of gear doesn't make me flinch (and maybe that'll be my next adventure after a couple more years of TRT-only lifting) - but something like SLU-PP-332 isn't even on the list of things I'm curious about.

I guess I'm OK being a guinea pig... just not one of the very first ones.
 
hexagonal said:
Not to mother anyone, but I am curious about the willingness to take something that has not yet had any human trials - we only have minimal results in animal trials, so lack of data around efficacy in humans combined with having no clue whether or not it is safe to use in humans makes me fairly wary.

How are you calculating the risk vs. reward here? What level of impact makes it worth the unknown level of risk?
Click to expand...
Vigorous Steve has been a trial of one :)
 
I got some tabs from Nexaph and yesterday, at 1 tab, 250mcg, was able to jog an entire 5k on the treadmill…. Fully 42 minutes in Zone 3 and did well. I know there’s a lot of chatter about mouse to human dosing levels but, anecdotally, I felt like it removed my gasping and the internal need to slow down. Was actually kinda weird.
 
The nexaph doses don’t make sense to me

The mouse dose was 50 mg/kg
The Km value for human is 37
The Km value for mouse is 3
The mouse to human ratio is 3/37
The human dose should then be 50 x (3/37) = 4.05 mg/kg

So someone that is 200 lbs is around 90 kg and should be taking around 364 mg not mcg.

Now also consider that the dose for mice was done intraperitoneal which had better bioavailability than oral which means the oral dose needs to be even higher, but you need to know the bioavailability to calculate.

Study: https://www.newswise.com/pdf_docs/169566414480099_jpet.123.001733.full.pdf
 
I listened to hunter Williams and just took the plunge. I do 3 x 250mg in the morning and at night. My weight loss was slowing previously but this bump started it again. You can definitely feel it in the gym too. If anyone is looking for this in the UK send me a message 👍🏻
 
glpfun said:
The nexaph doses don’t make sense to me

The mouse dose was 50 mg/kg
The Km value for human is 37
The Km value for mouse is 3
The mouse to human ratio is 3/37
The human dose should then be 50 x (3/37) = 4.05 mg/kg

So someone that is 200 lbs is around 90 kg and should be taking around 364 mg not mcg.

Now also consider that the dose for mice was done intraperitoneal which had better bioavailability than oral which means the oral dose needs to be even higher, but you need to know the bioavailability to calculate.

Study: https://www.newswise.com/pdf_docs/169566414480099_jpet.123.001733.full.pdf
Click to expand...
The species of interest is humans. Therefore we can do all the calculations until the cows come home and speculate. Allometric scaling is not perfect and does not factor in other things that a more advanced PB/PK model (and others) can. Therefore without this one can believe anything.....I believe I'll have another drink....
 
glpfun said:
The nexaph doses don’t make sense to me

The mouse dose was 50 mg/kg
The Km value for human is 37
The Km value for mouse is 3
The mouse to human ratio is 3/37
The human dose should then be 50 x (3/37) = 4.05 mg/kg

So someone that is 200 lbs is around 90 kg and should be taking around 364 mg not mcg.

Now also consider that the dose for mice was done intraperitoneal which had better bioavailability than oral which means the oral dose needs to be even higher, but you need to know the bioavailability to calculate.

Study: https://www.newswise.com/pdf_docs/169566414480099_jpet.123.001733.full.pdf
Click to expand...
Lots and lots of placebo effect folks having a fun time.
 
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