Sodium salt for compounded semaglutide

[inquiremind]

I asked the vendor I purchase semaglutide from regarding their compounding. They said they use sodium salts in making their semaglutide. Some quick research shows that using sodium salts has a high risk. Have you had this concern ?

 

[texmexpep]

Perhaps they mean sodium chloride bac water? That is what I use for semi and tirz. It doesn't work with everything but I've had no problem using it....and it's easier to find! Hospira brand with light green top.

 

[beingthere]

I don't think they were talking about production, probably reconstitution, and google translate is not always proficient in chinese, especially if the vendor uses a more or less local dialect. GLP's are peptides, sodium chloride is a mineral, therefore you cannot make glp from it and i never heard of SC being part of the manufacture processes. Very probaby bad translation

 

[ZippityDooDah]

I asked the vendor I purchase semaglutide from regarding their compounding. They said they use sodium salts in making their semaglutide.

Sodium is the counter-ion. With GLP's it's usually either a chloride or an acetate. The acetates tend to be more prone to ISR's, clouding, etc., but since most peptides are acetates many UGL's just stick with that process. Getting the sodium form is generally preferred, and freebase GLP's are not conducive to lyophilization and reconstitution.

Some quick research shows that using sodium salts has a high risk. Have you had this concern ?

Stop reading and believing big pharma and government bullshit disinformation designed to scare people away from alternatives to their cartel.

 

[GLP1Pharmacist]

Sodium salts high risks, doesn't simply make sense? If you are alive, you have sodium salts running through your veins.

 

[keangkong]

I asked the vendor I purchase semaglutide from regarding their compounding. They said they use sodium salts in making their semaglutide.

I'm impressed by the honesty of the vendor.

 

[inquiremind]

I don't think they were talking about production, probably reconstitution, and google translate is not always proficient in chinese, especially if the vendor uses a more or less local dialect. GLP's are peptides, sodium chloride is a mineral, therefore you cannot make glp from it and i never heard of SC being part of the manufacture processes. Very probaby bad translation

Yes I believe that was what I understood - that the reconstitution is done with sodium salt

 

[beingthere]

Yes I believe that was what I understood - that the reconstitution is done with sodium salt

If you reconstitute with sodium chloride water you either need to use it in 3 days or you should load your syringes and freeze them. No idea how much damage freezing is going to do to the peptide. Safest thing is alcohol bac water, keeps it bacteria free for at least a month. Sodium chloride water is the standard in medicine for reconstituting injectable compounds, safer and better tolerated than distilled water