SS-31 + MOTs-C vs NAD+

I am currently on Reta which I understand helps with mitochondrial health by promoting mitophagy. If instead of repairing the mitochondria with SS-31, you clean out the damaged mitochondria with Reta and let the process ride for a few months, which is plenty of time for turnover and replacement to occur. I would think after a few months MOTS-c would be more effective for someone who had compromised mitochondria. Does my logic hold up here, or am I missing something?
 
To me, that sounds like an ISR and not and allergic reaction like I had. How much bac did you use? For some peps and a lot of people, the amount of bac you add can make a big difference. The more bac you add, the less ISR issue because it's not as concentrated. (yes, that means more units to inject but worth it)
I've heard the same from others on increasing BAC, maybe filtering could help as well?
 
I dunno, but I'm so over it. Itchy lump the feels dine-sized and lasts two weeks, which means I'm always walking around with five (for a 3x per week schedule) and my belly is no longer big enough to really spread them out, space wise.
It's exhausting, I had this happen with Testosterone Subq but it's an oil base and known to cause this. I switched to IM and zero issues ever since. I'm going to filter my Mots-C to see if it helps prevent getting these reactions.
 
NAD+ and Mots-c give me energy and endurance(not like a preworkout like INSANE LABS PSYCHOTIC). I'm waiting on ss31 to be delivered and ready to on board that. SLU maybe next
 
It's exhausting, I had this happen with Testosterone Subq but it's an oil base and known to cause this. I switched to IM and zero issues ever since. I'm going to filter my Mots-C to see if it helps prevent getting these reactions.

Just so you don't get your hopes up too much; there's nothing I don't filter. I use pens, so I gotta transfer it from vial A to cartridge B anyway, figure it's dumb not to take the four seconds to unscrew the needle, and slap on a filter and a new needle.

Adding more BAC probably WOULD help, it does with KLOW, though the total volume of the dose that gets the right mg amount and doesn't cause an ISR isn't very high, only about 35 units for the one I have. For the MOTS-C, if you don't mind shooting up almost a ml of fluid (for 5mg) 3x per week, then it's likely to be the thing that helps. I just can't bear that; I get the mental image of drinking a cup of cocoa into a pocket of my belly fat and feel ill.
 
Last edited:
Just so you don't get your hopes up too much; there's nothing I don't filter. I use pens, so I gotta transfer it from vial A to cartridge B anyway, figure it's dumb not to take the four seconds to unscrew the needle, and slap on a filter and a new needle.

Adding more BAC probably WOULD help, it does with KLOW, though the total volume of the dose that gets the right mg amount and doesn't cause an ISR isn't very high, only about 35 units for the one I have. For the MOTS-C, If you don't mind shooting up almost ml of fluid (for 5mg) 3x per week, then it's likely to be the thing that helps. I just can't bear that; I get the mental image of drinking a cup of cocoa into a pocket of my belly fat and feel ill.
Good to know, thanks for sharing.
 
I'm currently on week 2 of SS-31. No NAD.

I started at 2 mg. This week I increased the dose to 4 mg which I will stay at 4mg. I plan to continue for another three weeks before introducing MOTS-c.

SS-31 has provided noticeably deeper/better sleep. I dose around 8pm and go to bed around 10:30pm. I am pleased with the results so far.
Are you using any wearable to track sleep quality? Ss31 wired my research subject and for that reason it was always taken in the am.
 
I've heard the same from others on increasing BAC, maybe filtering could help as well?
It's definitely worth doing, just to be on the safe side. I'm not great about filtering my own peps but I make sure to filter anything I recon for the family.
 
No, not an allergy; a very common ISR, similar to NAD+ (Even buffered.) I did 3 ml bac to 32mg. I don't want to double that, because I'm too grossed out by huge volume doses; at the concentration I have, it's like 47 units. I'd rather have the lump, but I dislike the choice and am glad the protocol's almost over it, even though I undeniably feel better.
I just realized I made a typo in this comment. I did NOT have an ISR, I only had an allergic reaction. If I only had an ISR, I'd deal with that and poke on. 😊
 
I just realized I made a typo in this comment. I did NOT have an ISR, I only had an allergic reaction. If I only had an ISR, I'd deal with that and poke on. 😊
oh no, you had it right--I was agreeing with you that no, mine isn't an allergy, just an ISR and a common one with MOTS-C. I agree that yours was DEFINITELY an allergy and not worth daring it to get worse.
 
I like to inject things that leave temporary marks on me (GHK, MOTS-C, etc) in less-visible areas, like the upper quad. It doesn't help with the bite, but at least you won't have to worry about the spots being visible to most.
 
Are you using any wearable to track sleep quality? Ss31 wired my research subject and for that reason it was always taken in the am.
No, sorry I do not wear anything. I went from waking up around 3-4am every night to waking up when my alarm clock goes off at 6am and i feel incredibly well rested. I wake up and I dont have to snooze the clock for half an hour.
 
So I started the Mots-C phase of the 14-week protocol this week. Started with 1 mg on Monday with no issues, not even an ISR which is good. Went to 2 mg today and I've been feeling a little dizzy all day. Not bad, just strange. I've been getting my water in, but it's still weird. Going to 3 mg Friday, which should tell me for sure. Then 5 mg the rest of the way, if it works out. Anyone else get that dizziness? I was more worried about a histamine reaction than anything and didn't get that.
 
So I started the Mots-C phase of the 14-week protocol this week. Started with 1 mg on Monday with no issues, not even an ISR which is good. Went to 2 mg today and I've been feeling a little dizzy all day. Not bad, just strange. I've been getting my water in, but it's still weird. Going to 3 mg Friday, which should tell me for sure. Then 5 mg the rest of the way, if it works out. Anyone else get that dizziness? I was more worried about a histamine reaction than anything and didn't get that.
Vestibular dizziness is not uncommon, as an issue separate from taking peps. Especially during viral infectious disease season. Maybe it would be a better test if you this let up before you try the next dose, that way it would seem more likely to not be a coincidence
 
Vestibular dizziness is not uncommon, as an issue separate from taking peps. Especially during viral infectious disease season. Maybe it would be a better test if you this let up before you try the next dose, that way it would seem more likely to not be a coincidence
The protocol is 3x a week, so I'll have tomorrow to recover, if needed. I don't think it's related to the flu or illness because it started within 20 minutes of my dose this morning. Going up 1 mg on Friday should tell me if it's the cause. We're all lab rats. 🐀
 
Not so much thinking you can’t tolerate it, but if it doesn’t go away before you take another dose and it escalates, it will have less confidence to decide if it’s just a coincidence or due to the mots. I hope it just goes away!
 
Not so much thinking you can’t tolerate it, but if it doesn’t go away before you take another dose and it escalates, it will have less confidence to decide if it’s just a coincidence or due to the mots. I hope it just goes away!
Thanks, me too. I understand that correlation doesn't equal causation, also. We'll see what happens.
 
So I started the Mots-C phase of the 14-week protocol this week. Started with 1 mg on Monday with no issues, not even an ISR which is good. Went to 2 mg today and I've been feeling a little dizzy all day. Not bad, just strange. I've been getting my water in, but it's still weird. Going to 3 mg Friday, which should tell me for sure. Then 5 mg the rest of the way, if it works out. Anyone else get that dizziness? I was more worried about a histamine reaction than anything and didn't get that.
I’m coming up on the final 3 weeks of the protocol. The RS has been tolerating the peps very well. I also have been following the protocol dosages. The previous MOTSc (number 5) dose did result in an itchy area. Nothing too bad, but there was a reaction. The RS was introduced to GLOW during the protocol to see if there would be a ISR to that blend. To prep for GLOW, the RS took oral anti-histamine meds. I’m thinking now the anti-histamines for GLOW may have helped the first few rounds of MOTSc. Today is dose number 6. Will see how it goes. BTW, the 100mg NAD+ does leave a lump. The reconstitution ratio requires 40 units for 100mg.

Throughout this process, energy levels have been elevated. Workout performance is better. Higher numbers when compared to previous workouts, I have been pleased with the whole process.
 
Follow up from yesterday’s post. This RS did have a lump from dose number 6 of 5mg MOTSc. Using 1/2 pin in the fleshy glute area. A little itch and the lump is still there after 24 hours. Next one is tomorrow.
 
Pinned the 5mg MOTSc today. The things I did differently are administered Zyrtec anti-histamine orally before the pin. Immediately after the pin, I used a vibe gun on the RS for over 5 minutes. Together, these precautions made the reactions from MOTSc very minimal. Got about 1o more to go.
 
Pinned the 5mg MOTSc today. The things I did differently are administered Zyrtec anti-histamine orally before the pin. Immediately after the pin, I used a vibe gun on the RS for over 5 minutes. Together, these precautions made the reactions from MOTSc very minimal. Got about 1o more to go.
I titrated up to 3 mg Mots-C last week. I start 5 mg tomorrow. So far, I've had no adverse reaction, not even an ISR. 🤞
 
I titrated up to 3 mg Mots-C last week. I start 5 mg tomorrow. So far, I've had no adverse reaction, not even an ISR. 🤞
Totes jelly. I really liked MOTS-C; I honestly liked the whole mitochondrial protocol. I really DID feel better during and after. But the hard lumps for weeks was just one gross out too far.
 
Holy Shit. I researched the 5 mg dose Mots-C this morning about 5 hours ago and liftoff has commenced. Is this what meth feels like? I feel like I could fight a bear. I did a lot of, er, substances in the 70s and 80s, but never meth.

My mood is up and I'm pacing my office while on phone calls. This is nuts. I'm not sure how I'm going to follow the protocol for 6 more weeks because I'm going to run out of bears to fight and there are a lot of them where I live. Anyone else find this to be like clean rocket fuel?
 
Holy Shit. I researched the 5 mg dose Mots-C this morning about 5 hours ago and liftoff has commenced. Is this what meth feels like? I feel like I could fight a bear. I did a lot of, er, substances in the 70s and 80s, but never meth.

My mood is up and I'm pacing my office while on phone calls. This is nuts. I'm not sure how I'm going to follow the protocol for 6 more weeks because I'm going to run out of bears to fight and there are a lot of them where I live. Anyone else find this to be like clean rocket fuel?
What is your heart rate like? What is your blood pressure like?
 
UP. I'm buzzing like a bee. It would be hard to get a true reading because of Reta.

Edit: BP is 132/90. Slightly elevated from normal
Thanks. It's very odd since when I search online, it says multiple studies associate MOTS-C with a lower BP and HR (!) But after reading your comment, I really begin to wonder. I have a kit I was suppose to use but I need to keep my BP & HR in check. On a side note, do you use anything to lower your BP? I've recently switched to Telmisartan; seems to work nicely.
 
Thanks. It's very odd since when I search online, it says multiple studies associate MOTS-C with a lower BP and HR (!) But after reading your comment, I really begin to wonder. I have a kit I was suppose to use but I need to keep my BP & HR in check. On a side note, do you use anything to lower your BP? I've recently switched to Telmisartan; seems to work nicely.
I've been taking Lisinopril for several years. My doc says 10 mg is a baby dose, but it works. I have a cuff at home, but since starting Reta, I have a lot more variation in both numbers it seems.

The good news about yesterday day is that it had worn off by the end of day and was able to get a good night's sleep. My mild anxiety may have also been a factor as I hadn't experienced such a clean hit of energy in decades, if ever. I do still recommend it though. Everyone is different, but the difference between 3 mg and 5 mg Mots-C to me was a game changer. It may not be for you.
 
Finished this protocol this week and I enjoyed it overall. The SS-31 for the first half did the most for me, something I could notice. The back half with Mots-C did not have the same “I’m on something”. I’ll probably run this again as I gained a clear head and more energy that offset the Reta. SS-31 3mg, Mots-C 5mg, NAD+ 150mg
 
Finished this protocol this week and I enjoyed it overall. The SS-31 for the first half did the most for me, something I could notice. The back half with Mots-C did not have the same “I’m on something”. I’ll probably run this again as I gained a clear head and more energy that offset the Reta. SS-31 3mg, Mots-C 5mg, NAD+ 150mg
Thanks for the update. I’m in the final weeks. 3 NAD+ and 6 more MOTSc doses to go. My research mirrors yours. The SS-31 along with NAD+ for 6 weeks was amazing. Mentally and physically had so much endurance. The daily SS-31 pin was annoying at first, but I really missed it when completed. MOTSc is leaving welts and itching, nothing too uncomfortable tho. This is the 14 weeks protocol, 4mg SS-31, 100mg NAD+ and 5mg MOTSc. Not sure what’s next for me. Was planning a GLOW or KLOW cycle but may do Tesamorelin for a couple months first.
 

Trending Topics

Forum Statistics

Threads
17,657
Posts
183,271
Members
59,375
Newest
Hhhehehshshshs
Back
Top Bottom