Ss-31 & Mots-c

[Jordaboo]

I am wanting to start Mots-C, after lots of reading it is apparently suggested to do or start a cycle with SS-31 to repair mitochondrial health before starting the. Mots-C or it’s basically a waste.

Any opinions on this subject would be appreciated!

 

[Skidude]

There are many opinions, you can find a lot here: SS31 THREAD

The protocol I have used a few times calls for 5mg SS31 5/2 for 4 weeks than overlap a few weeks with MOTS-C before stopping SS31.

There are those who believe the dosage is too small at 5mg or that the pep is too expensive to use a high enough dose.
I am satisfied with the cycle and "feel" it may have benefitted my long term strategy of optimizing all supplement/peps I use.

Take a look at that thread and I believe @Calm Logic has posted a great deal about this stack as well.

I am currently on the overlap portion of mots on second cycle of ss31/mots and "feel" it was worth the investment on a risk/reward comparison.

I also cut my food budget down by $400+ per month, so ss31 is now my door dash mad money..lol

 

[Jordaboo]

There are many opinions, you can find a lot here: SS31 THREAD

The protocol I have used a few times calls for 5mg SS31 5/2 for 4 weeks than overlap a few weeks with MOTS-C before stopping SS31.

There are those who believe the dosage is too small at 5mg or that the pep is too expensive to use a high enough dose.
I am satisfied with the cycle and "feel" it may have benefitted my long term strategy of optimizing all supplement/peps I use.

Take a look at that thread and I believe @Calm Logic has posted a great deal about this stack as well.

I am currently on the overlap portion of mots on second cycle of ss31/mots and "feel" it was worth the investment on a risk/reward comparison.

I also cut my food budget down by $400+ per month, so ss31 is now my door dash mad money..lol

When I originally searched SS31 in the search bar nothing popped up, than I went into the posts on the side and found it & did some reading!
So so many different opinions on how to dose/stack that’s for certain!
Next thing is finding the SS-31, I can find the mots all day but not the ss-31

 

[Jordaboo]

I see

When I originally searched SS31 in the search bar nothing popped up, than I went into the posts on the side and found it & did some reading!
So so many different opinions on how to dose/stack that’s for certain!
Next thing is finding the SS-31, I can find the mots all day but not the ss-31

I see HK Peptide has it for a decent price, just haven’t seen many reviews on here from that vendor…

 

[Skidude]

When I originally searched SS31 in the search bar nothing popped up, than I went into the posts on the side and found it & did some reading!
So so many different opinions on how to dose/stack that’s for certain!
Next thing is finding the SS-31, I can find the mots all day but not the ss-31

Nexa usually has reasonable prices when you compare 10mg to 30mg kits (theirs is 30mg)

 

[hexagonal]

I didn't notice anything doing the SS-31 -> SS-31/MOTS-C -> MOTS-C stack. I've had no luck with any of the mitochondrial enhancers though, peptide or otherwise.

 

[Calm Logic]

It seems to know if it did help at the cellular level (or how much), you would need expensive testing like an Organic Acids Test or telomere length test, before and after, and even then you wouldn't know for sure.

 

[Skidude]

It seems to know if it did help at the cellular level (or how much), you would need expensive testing like an Organic Acids Test or telomere length test, before and after, and even then you wouldn't know for sure.

my exact thought, how do you quantify this?
I don't know if it helped, but I thought it was worth a shot.

 

[PopTart]

I love ss-31….did 3 months @ 4mg daily pinned at night. Just felt much more alert. I’m also in my early 60s.

Been on mots-c for a month @ 5mg every other day and pinned in the A.M. ….started it when I started the 3rd month of ss-31. Didn’t feel any noticeable difference after being on the ss-31.

Going to add NAD+ on June 1 and run it for a couple months.

 

[TRS123]

I love ss-31….did 3 months @ 4mg daily pinned at night. Just felt much more alert. I’m also in my early 60s.

Been on mots-c for a month @ 5mg every other day and pinned in the A.M. ….started it when I started the 3rd month of ss-31. Didn’t feel any noticeable difference after being on the ss-31.

Going to add NAD+ on June 1 and run it for a couple months.

Hello
58 yr old male subject. Realizing some early age related memory issues just don’t feel as sharp mentally as I used to be. Have been on NAD for 4 weeks now 3x a week have ss-31 on the way should arrive next week. I’m interested in your experiment with ss31. On your protocol are you taking a break after x number of weeks? Did you take daily?

 

[RadicalCrimson]

I started Mots-C at 5mg/day 5/7 for a week, but interrupted to research SS-31. Will resume concomitantly after 10-14 days.
I'm following the 10mg/day for 30 days protocol, common due to being prescribed with a 300mg/6ml vial.
I blend 5 vials of the 30mg kit into a 3ml pen cartridge, use 18-20 units per injection.

 

[RocketGotRobbed]

I don't want to bring anyone down but I can tell you what the human trials of ss31 say. They had 0 luck in the human tests. The mechanism is legit but it just didnt translate to humans the way it did in vitro.

 

[TRS123]

I haven’t seen any cognitive human trials. Good or bad. If you have a link to the study you are referencing please post

 

[Calm Logic]

I don't want to bring anyone down but I can tell you what the human trials of ss31 say. They had 0 luck in the human tests. The mechanism is legit but it just didnt translate to humans the way it did in vitro.

If you are referring to the MMPOWER-3 trial:

Genotype-specific effects of elamipretide in patients with primary mitochondrial myopathy: a post hoc analysis of the MMPOWER-3 trial - Orphanet Journal of Rare Diseases

Background As previously published, the MMPOWER-3 clinical trial did not demonstrate a significant benefit of elamipretide treatment in a genotypically diverse population of adults with primary mitochondrial myopathy (PMM). However, the prespecified subgroup of subjects with disease-causing...

ojrd.biomedcentral.com

"Post hoc analyses indicated that elamipretide had a beneficial effect in PMM patients with mtDNA replisome disorders, underscoring the importance of considering specific genetic subtypes in PMM clinical trials. These data serve as the foundation for a follow-up Phase 3 clinical trial (NuPOWER) which has been designed as described in this paper to determine the efficacy of elamipretide in patients with mtDNA maintenance-related disorders."

Human studies of SS-31 with good results:

https://www.jacc.org/doi/abs/10.1016/j.jacbts.2018.12.005

"Treatment of explanted human hearts with elamipretide [SS-31] improves human cardiac mitochondrial function."

https://www.ahajournals.org/doi/full/10.1161/CIRCINTERVENTIONS.117.005487

"During PTRA, patients were assigned randomly to either elamipretide (0.05 mg/kg per hour, n=6) or identically prepared placebo (n=8) infusion, which started 30 minutes before PTRA."

"Adjunctive elamipretide during PTRA was associated with attenuated postprocedural hypoxia, increased RBF, and improved kidney function in this pilot trial. These data support a role for targeted mitochondrial protection to minimize procedure-associated ischemic injury and to improve outcomes of revascularization for human atherosclerotic renal artery stenosis."

Similarly, a dog study with good results for heart failure:

https://www.ahajournals.org/doi/full/10.1161/CIRCHEARTFAILURE.115.002206

"Long-term therapy with elamipretide improves LV systolic function, normalizes plasma biomarkers, and reverses mitochondrial abnormalities in LV myocardium of dogs with advanced HF. The results support the development of elamipretide for the treatment of HF."