SSA has Orforglipron for sale

[lessthanhalf]

I just had a look at the latest SSA price list, and they have Orforglipron for sale. Maybe other people knew it was already around, but it is the first time I have seen it for sale. It is not a lot of use to me personally as maximum effectiveness is more important to me than convenience ( trying to keep off 72kg long term hopefully ). But for a lot of the population who are not keen on injecting themselves, it is great news. From my quick reading of the studies it sounds about as effective for weight loss as semaglutide, max 14.7% , with less nausea and vomiting , but possibly more diarrhoea, but overall it sounds like less gi side effects. A bit expensive at $185 usd for 100 12mg pills, doses in the studies were 6 to 45mg. I am not sure this forum is its target market but it is not hard to imagine it being very popular.

 

[penewbie]

Very interesting. Would probably be good for some of my needlephobic friends.

 

[Humphries365]

I cant find it on the price list?

 

[vewdew34]

I cant find it on the price list?

You have to get the new list it was updated today.

 

[byefatlicia]

Are COAs a thing for tablets? Or can they generally be trusted as accurate?

 

[penewbie]

Are COAs a thing for tablets? Or can they generally be trusted as accurate?

They're definitely a thing for tablets. Probably Jano doesn't have a test up and running yet. Tablets are some of the least trustworthy products. Super high variability of mass.

 

[byefatlicia]

They're definitely a thing for tablets. Probably Jano doesn't have a test up and running yet. Tablets are some of the least trustworthy products. Super high variability of mass

Good to know. I wouldn't want to get my friend sick🙂

 

[geoguy78]

Could be an interesting option for maintenance. From what I've seen though, oral med dosing here in the gray market world is super inconsistent. Definitely something to watch and see if others take the plunge first lol

 

[vewdew34]

Good to know. I wouldn't want to get my friend sick🙂

Its just that some manufacturers use more filler than actual drug, same with most of the supplements you get out of amazon. Or you think everything from amazon is 100%.

 

[byefatlicia]

Does anyone have info on how to get a test that is not crazy expensive?

 

[mlke6]

Does anyone have info on how to get a test that is not crazy expensive?

You put in an extra large order, send for testing, sell what you don't want.

 

[byefatlicia]

You put in an extra large order, send for testing, sell what you don't want.

yeah, but who tests tablets?

 

[penewbie]

Its just that some manufacturers use more filler than actual drug, same with most of the supplements you get out of amazon. Or you think everything from amazon is 100%.

Nearly every manufacturer uses more filler than actual drug. That's how tablets work, even with pharma.

 

[geoguy78]

yeah, but who tests tablets?

Jano definitely tests tablets. Not sure about domestic (US) based labs.

 

[rsmith]

<off topic>

I noticed SSA also has 20mg. Cagri. I've never seen it in such a large size but with big pharma studying it now as a combination with GLP's, it may start getting more popular and cheaper. I imagine that I will eventually be on a bigger dose when I get to maintenance and where 20mg. kits make financial sense.

 

[rsmith]

I just had a look at the latest SSA price list, and they have Orforglipron for sale. Maybe other people knew it was already around, but it is the first time I have seen it for sale. It is not a lot of use to me personally as maximum effectiveness is more important to me than convenience ( trying to keep off 72kg long term hopefully ). But for a lot of the population who are not keen on injecting themselves, it is great news. From my quick reading of the studies it sounds about as effective for weight loss as semaglutide, max 14.7% , with less nausea and vomiting , but possibly more diarrhoea, but overall it sounds like less gi side effects. A bit expensive at $185 usd for 100 12mg pills, doses in the studies were 6 to 45mg. I am not sure this forum is its target market but it is not hard to imagine it being very popular.

This one's coming down the pike and will likely be available in the gray market long before it's commercially available (like Reta is). It's an oral formulation and a quad-receptor agonist. Next up, quintuple-receptor agonist. Stay tuned...

https://firstwordpharma.com/story/5...tigational, oral,many of which are injectable

 

[Jack brown]

If anyone is planning on trying it, can they check back in here with how it goes?

 

[geoguy78]

This one's coming down the pike and will likely be available in the gray market long before it's commercially available (like Reta is). It's an oral formulation and a quad-receptor agonist. Next up, quintuple-receptor agonist. Stay tuned...

https://firstwordpharma.com/story/5991011#:~:text=NA-931 (Bioglutide™)—an investigational, oral,many of which are injectable

I'm all in on an oral quad receptor. Even an oral dual or triple agonist. While I don't mind pinning myself weekly, I'm not addicted to pinning myself with a million different questionable peps and I'd love to just stop injecting myself period.

 

[byefatlicia]

If anyone is planning on trying it, can they check back in here with how it goes?

I now have an embarrassing amount of Tirz. (I might have a problem) Other than stacking with Survo, I don't plan on changing much. I love the concept of it tho. My fear is that it would be harder on the stomach. I'm not sure if that would be the case.

 

[GLP1Pharmacist]

This one's coming down the pike and will likely be available in the gray market long before it's commercially available (like Reta is). It's an oral formulation and a quad-receptor agonist. Next up, quintuple-receptor agonist. Stay tuned...

https://firstwordpharma.com/story/5...tigational, oral,many of which are injectable

Triple plus Sema wonder how it would compare to Reta plus Sema?

 

[Dogmandu]

Its just that some manufacturers use more filler than actual drug, same with most of the supplements you get out of amazon. Or you think everything from amazon is 100%.

'Filler' is a consumer term with some baggage, implying non-essential bulking agents added for profit.

I'm both a GLP enthusiast/consumer and a manufacturer of pills (my profession). The term for 'filler' is excipients. They are never present to provide bulk or trick consumers. Excipients always perform functions: binders (usually cellulose derivatives), disintegrants (croscarmellose sodium, crospovidone), flow agents (glidants like silicon dioxide or talc), lubricants (stearic acid or Mag stearate), coatings, and stabilizers.

They all serve a purpose. Active ingredients do not easily or willingly tablet or capsule themselves. I promise you that we don't put these things into pills to fool or trick anyone. We use as little of each as we must.

Having said all that, supplements on Amazon is a different can of worms. You're right about that. It's a Wild West of Chinese brands pretending to be American, anonymous American 'brands' whose owners are also selling yoga mats and life coaching, and some legitimate brands who care about quality and health. Third-party testing by NOW Foods shows that many of them are just plain, as you call it, fillers or rice powder. https://www.nowfoods.com/healthy-li...-quality-issues-supplement-brands-sold-amazon

If you're shopping for a supplement, call the company. See if anyone picks up. Ask for a CoA, just like you would SRY or SSA.

 

[rsmith]

Triple plus Sema wonder how it would compare to Reta plus Sema?

At some point, combinations must be complementary rather than competitive/antagonistic. Otherwise, you could just stack Sema, Tirz, Reta, Bioglutide, Survo for an 11X receptor agonist. The primary downside to this approach is that you could end up weighing zero (RIP). 😴

 

[zebit0]

Jano says he can test this.

 

[Calm Logic]

Orforglipron seems exciting to me since the half life is much shorter, like one to two days, which I like for stacking.

 

[Thistley]

I think it’s very interesting how little has been heard about Orforglipron, seems the media are content to continue to write and talk about Tirz ( by design? Paid to do so?) and keep the focus firmly there as well as more recently on danger ⚠️ Reta.

Likely to do with the results. With the weight loss being much less than injectables (7.9%). But more control over daily dosing and more palatable to mass market. And yet….orforglipron is further on in the clinical trials having completed ATTAIN phase 3 and showing a comparable safety profile to other GLP1s. Looks like the plan is to submit to the regulator by the end of the year. I’ll be curious to see what their strategy is going forward. Will it be their “ cheap” to plug the gap in the market option?

Also reading last night about a new quad agonist in trials called peptide YY. N Nordisk and Lilly have products in development. Two of NN’s PYY3-36 analogues (NN9748 and NNC0165-1875) have completed Phase I trials for the treatment of obesity.

 

[GLP1Pharmacist]

Ok, so who is already planning to add to stack lol 😆

 

[Calm Logic]

I was considering ordering, but I am liking my survo+tirz stack so far. And I still have to try sema some more, reta, cagri, and maz 😀

But with the shorter half-life, it gladly takes away any temptation to get more lira pens from India.

 

[rsmith]

I think it’s very interesting how little has been heard about Orforglipron, seems the media are content to continue to write and talk about Tirz ( by design? Paid to do so?) and keep the focus firmly there as well as more recently on danger ⚠️ Reta.

Likely to do with the results. With the weight loss being much less than injectables (7.9%). But more control over daily dosing and more palatable to mass market. And yet….orforglipron is further on in the clinical trials having completed ATTAIN phase 3 and showing a comparable safety profile to other GLP1s. Looks like the plan is to submit to the regulator by the end of the year. I’ll be curious to see what their strategy is going forward. Will it be their “ cheap” to plug the gap in the market option?

Also reading last night about a new quad agonist in trials called peptide YY. N Nordisk and Lilly have products in development. Two of NN’s PYY3-36 analogues (NN9748 and NNC0165-1875) have completed Phase I trials for the treatment of obesity.

FWIW, both NN9748 and NNC0165-1875 appear to be duds.

NN9748 and NNC0165-1875 were investigational drugs developed by Novo Nordisk for treatment of obesity. Both are long-acting analogues of the hormone peptide YY (PYY) and completed early clinical trials.

Development of PYY analogues

• Purpose: The body's naturally occurring PYY has a short half-life, meaning it is cleared from the body quickly. To be effective as a medication, a long-lasting version was needed. NN9748 and NNC0165-1875 were developed as long-acting PYY analogues to extend the effect of the hormone.
• Mechanism: As analogues of PYY, both NN9748 and NNC0165-1875 act on the Y2 receptor, which helps control appetite and food intake.

Trial status and results

• NN9748: This analogue completed Phase I clinical trials for the treatment of obesity and type 2 diabetes but has not progressed further.
  • Phase I: NNC0165-1875 was tested alone and in combination with semaglutide in a Phase I study and found to be tolerable.
    • While it produced some additional weight loss in obese rats, the effect in humans was considered modest and not clinically meaningful when combined with semaglutide.
    • The drug also caused frequent gastrointestinal side effects in human subjects, especially at higher doses, leading to poor tolerability.
  • Conclusion: The Phase II results indicated that NNC0165-1875 had limited efficacy as an add-on treatment and poor tolerability. The trial was completed in January 2023.