Stacking Tirz with reta?

[joeylev]

My subject is currently on 9mg of tir split 2 times a week. I stalled a few months ago but am trying to not max my dose because I know I can not go any higher then 12mg a week. Has anyone added reta on with it? Does anyone have any suggestions on what to stack with tir if not okay with the reta?

 

[latviantower]

12 mg per week is the recommended max for reta, not tirz - tirz is 15 mg per week. And many folks safely exceed that by increasing dose or pinning more frequently.

 

[joeylev]

12 mg per week is the recommended max for reta, not tirz - tirz is 15 mg per week. And many folks safely exceed that by increasing dose or pinning more frequently.

Thank you! Do you know if it is safe to use both?

 

[desinr-gal]

I am stacking Reta with Tirze, but both low doses. I like it a lot.

 

[Calm Logic]

At high enough doses without sufficient titration, even reta alone can cause problems, like 24/7 hiccups:

GYC Reta 50 GB

I know a lot of people haven’t received theirs yet but I’m hoping to find anyone who has received the recent GYC Reta 50 GB and started using it. I’ve been using Reta from other sources (Nexaph, SSA and QSC) for a long time. But what I am experiencing after trying this GYC Reta is unlike...

glp1forum.com

A potential problem with stacking, without an established protocol, is if you wake up adventurous one morning and inject far more than you normally would, intentionally or not.

Having said that, I haven't read anyone having any hospital visits from stacking, except one person titrating cagri too aggressively.

 

[latviantower]

Thank you! Do you know if it is safe to use both?

Published safety guidelines warn against stacking glp meds. That said, many researchers in these spaces have had individual success stacking tirz and reta. Dosages, titration schedules and frequency are personal decisions.

 

[Nailedit]

I'm stacking both on lower doses. 5.5mg tirz and 1mg reta. Working very well for me. I will probably eventually apm up the reta and reduce the tirz to see how that works. But as long as this is working I'll keep it as is.

 

[peptidepower77]

I stacked both and my fasting insulin sky rocketed. I suspect it was because the tirz + reta screwed up the balance with GIP + GLP1 that reta was designed for. So I don't recommend doing it. As soon as the tirz left my system, my fasting insulin returned to normal. The glucagon component in reta drives hyperglycemia, so I think it's a bit risky messing with GIP + GLP1 as I learned doing it and from my blood work.

 

[lessthanhalf]

Initially lost 90%+ of the weight without medication as I believed I could not afford it. Got from 145 to about 76 to 80kg , which was a few kilos heavier than my target but I just could not lose more weight, and compared with not being able to walk 100m without being exhausted, was pretty good. Worked out that low dose ozempic was not too expensive here in Australia, so started that. I swapped from semaglutide ( horrible nausea constantly for a year ) to tirzepatide, both prescribed by my doctor, about 3 months ago, no real problems with tiz except for the price. Then I found this site and bought some from china, it was much cheaper and the dose did not have to depend on cost. I had to take ozempic in tiny doses- 0.2mg every 2 days to reduce nausea, and just kept going with 2nd daily dosing on tiz, uptitrated dose to 4.25mg per 2 days over a month ( no I do not recommend this ). I was still a bit hungry so added in a bit of reta 1mg or so per 2 days. Apart from an episode of daily migraines for a week which might or might not have been due to the reta, so far so good. I just stopped it for a few days and restarted slowly, and it has not happened again. I have been losing 0.5kg per week for the past 2 months or so without constant effort of forcing myself to eat less than I would like, which in my experience you can do for a while but not very long term. Finally made exactly half my start weight this week from 145kg to 72.5. I am happy that it might just be possible to maintain 50% weight loss without being permanently hungry. I am fairly surprised by the lack of horrible side effects of full doses of tirzepatide plus a smallish dose of retatrutide, compared to the problems I had with ozempic.

 

[latviantower]

Congratulations! Well done. Admire the disciplined approach.

 

[Batscout]

I am using 3 mg reta and 5 mg tirz every 10-14 days. It works fine for me.

 

[HoopFan]

I am using 3 mg reta and 5 mg tirz every 10-14 days. It works fine for me.

Q: on the same day or spaced out?

I’m likely going into maintenance soon, so will be looking at what works best.

 

[vewdew34]

I stacked both and my fasting insulin sky rocketed. I suspect it was because the tirz + reta screwed up the balance with GIP + GLP1 that reta was designed for. So I don't recommend doing it. As soon as the tirz left my system, my fasting insulin returned to normal. The glucagon component in reta drives hyperglycemia, so I think it's a bit risky messing with GIP + GLP1 as I learned doing it and from my blood work.

Funny I did have a fasted blood sugar of 116 since I started stacking Tirz + Reta, i am not a diabetic but now I will keep an eye just to see if it will happen again.

 

[peptidepower77]

Funny I did have a fasted blood sugar of 116 since I started stacking Tirz + Reta, i am not a diabetic but now I will keep an eye just to see if it will happen again.

I think that's the problem. GLP1 + GIP modify insulin secretion and insulin sensitivity. The glucagon component forces the liver to produce sugar. If you screw up these ratios, the body may inappropriately respond to sugar, either producing too much or too little insulin. So I don't think stacking two GLP1 medications is a good idea, nor do the companies that make them.

 

[latviantower]

I think that's the problem. GLP1 + GIP modify insulin secretion and insulin sensitivity. The glucagon component forces the liver to produce sugar. If you screw up these ratios, the body may inappropriately respond to sugar, either producing too much or too little insulin. So I don't think stacking two GLP1 medications is a good idea, nor do the companies that make them.

So imagine the permutations of stacking nightmares involving semaglutide, tirzepatide, retatrutide AND bioglutide??

 

[peptidepower77]

So imagine the permutations of stacking nightmares involving semaglutide, tirzepatide, retatrutide AND bioglutide??

Yah, I think you're rolling the dice. It might work, or it might be counterproductive. Glucagon was used on its own for weight loss in the 50s and 60s but stopped because it resulted in hyperglycemia. The only reason it's a medication now is because it was carefully balanced (or unbalanced as people like to say since the ratios are unique) with GLP1 and GIP as well. So those ratios are pretty important I think, and adding another GLP1 of GIP antagonist might screw up the delicate balance.

 

[randompersonrandom]

Yah, I think you're rolling the dice. It might work, or it might be counterproductive. Glucagon was used on its own for weight loss in the 50s and 60s but stopped because it resulted in hyperglycemia. The only reason it's a medication now is because it was carefully balanced (or unbalanced as people like to say since the ratios are unique) with GLP1 and GIP as well. So those ratios are pretty important I think, and adding another GLP1 of GIP antagonist might screw up the delicate balance.

This is something I've been feeling really uneasy about. I personally have been stacking a tiny dose (0.3mg every six days) of Survo against a fairly low amount (5mg) of tirz weekly. I added the Survo because I've read a lot of people saying that it counteracts the tirz fatigue. I DO feel better and less tired, but I'm also troubled because ok, grey market tirz was fine, I'm reasonably sure it's the same thing as the compound I was taking with no problems. But I don't do reta because a) I'm uneasy about anything that revs the metabolism; I know it's not speed, but running a machine in a higher gear worries me and b) it's not all the way through trials yet and we have no info on the long term effects. And yet here I am effing around with Survo, which has both of those worry points for me.

I feel like the stack is something I likely won't be confident enough to do long-term, safety wise, and I'm soothing my anxious soul by reminding myself that it's a fairly tiny dose and it'll be hard to do significant unknown damage with that. But yeah, I'm nervous.

 

[mlke6]

This is something I've been feeling really uneasy about. I personally have been stacking a tiny dose (0.3mg every six days) of Survo against a fairly low amount (5mg) of tirz weekly. I added the Survo because I've read a lot of people saying that it counteracts the tirz fatigue. I DO feel better and less tired, but I'm also troubled because ok, grey market tirz was fine, I'm reasonably sure it's the same thing as the compound I was taking with no problems. But I don't do reta because a) I'm uneasy about anything that revs the metabolism; I know it's not speed, but running a machine in a higher gear worries me and b) it's not all the way through trials yet and we have no info on the long term effects. And yet here I am effing around with Survo, which has both of those worry points for me.

I feel like the stack is something I likely won't be confident enough to do long-term, safety wise, and I'm soothing my anxious soul by reminding myself that it's a fairly tiny dose and it'll be hard to do significant unknown damage with that. But yeah, I'm nervous.

as far as the fatigue goes did you evaluate your diet to see if maybe fuel may have caused some issues?

 

[HoopFan]

This is something I've been feeling really uneasy about. I personally have been stacking a tiny dose (0.3mg every six days) of Survo against a fairly low amount (5mg) of tirz weekly. I added the Survo because I've read a lot of people saying that it counteracts the tirz fatigue. I DO feel better and less tired, but I'm also troubled because ok, grey market tirz was fine, I'm reasonably sure it's the same thing as the compound I was taking with no problems. But I don't do reta because a) I'm uneasy about anything that revs the metabolism; I know it's not speed, but running a machine in a higher gear worries me and b) it's not all the way through trials yet and we have no info on the long term effects. And yet here I am effing around with Survo, which has both of those worry points for me.

I feel like the stack is something I likely won't be confident enough to do long-term, safety wise, and I'm soothing my anxious soul by reminding myself that it's a fairly tiny dose and it'll be hard to do significant unknown damage with that. But yeah, I'm nervous.

I don’t believe that Reta revs up metabolism that much. I mean if so, then you could dose less than Tirz. Maybe I’m not thinking right - I’m still sipping my morning coffee.