Starting to kick in?

[Vash_]

Only ate half my lunch yesterday and didn't finish my dinner today. Odd for me.
I'm on week two. I don't "feel" anything but, I'll attribute it to the Reta.

Curious to see how it goes as I increase the dose. Reading the Phase 3 results from Lilly today was encouraging. How many of you are on doses in the 9-12mg range? Seems like the various studies land there for best results.

 

[Thistley]

Don’t worry too much about feeling like you have to get to that dosage level for it to “work”at its most effective. That’s the trial dosage but in the real world, many ordinary people don’t respond that way.

Me for example: 15mg of tirz according to the EL trials was the most effective dose with the biggest % of weight loss. I took tirz for a year and titrated up as directed by professional provider. Not for me ~ and I spent months taking 15mg with little effect. Latterly no effect at all ( on scale).

5mg was actually most effective dose for me and I lost the most weight there. Moved up when I was told to by my provider. In hindsight I Should have stayed there for as long as I could have.

Have a close friend taking mounjaro who took my advice and stayed on 2.5mg and has lost 30lbs in just a few weeks.

Have learned my lesson with Reta, and now take as little as possible for as long as possible to achieve results. 6mg once a week working well for me and I have no intention to move up, unless I have to.

Depends on your goals of course. I’m in it for the long game. 90lbs down and maybe 30-40 still to go.

 

[Calm Logic]

I would have to be on uppers to be on a high dose anyway. The fatigue and GI issues are the limiting factors with me, and I've been back at a low dose for a while now.

 

[MsGizmo]

Only ate half my lunch yesterday and didn't finish my dinner today. Odd for me.
I'm on week two. I don't "feel" anything but, I'll attribute it to the Reta.

Curious to see how it goes as I increase the dose. Reading the Phase 3 results from Lilly today was encouraging. How many of you are on doses in the 9-12mg range? Seems like the various studies land there for best results.

The funny thing is that the reduction of appetite, AKA "food noise" could easily go unnoticed except for the fact that many of us that desire to lose weight have become hyper focused on our eating due to many past attempts of trying to lose weight through dieting. The use of GLP1s have made eating less so easy to do that it is called "cheating" to take one.

I know that I am eating less. I know that I don't crave junk the way that I used to. I'm not trying to resist anything. I just don't want any of it. Its like my eating habits have reverted back to what they were before I got pregnant with my first child nearly 30 years ago.

My current protocol is 2mg of sema on Sunday and 5mg of reta on Wednesday. I have lost roughly 50 pounds since early May 2025.
other thread that outlined what I've taken

I have been considering slowly reducing the sema as I increase the reta to 8mg. Not really sure just yet. I have 4 weeks to decide what changes to make or if I make any changes at all. My ultimate goal it to lose another 130 pounds and transition to just taking the sema for maintenance. A girl can dream.

 

[YoYoFat]

The funny thing is that the reduction of appetite, AKA "food noise"

Food noise and appetite are two entirely different things for me.

Food noise is mental. Appetite is physical.

 

[MsGizmo]

Food noise and appetite are two entirely different things for me.

Food noise is mental. Appetite is physical.

Food noise is not mental. Its exactly the same hormones in play. You are just trying to imply that some hunger is more legitimate based on how you respond to it or what time of day it happens.

 

[Really?]

Only ate half my lunch yesterday and didn't finish my dinner today. Odd for me.
I'm on week two. I don't "feel" anything but, I'll attribute it to the Reta.

Curious to see how it goes as I increase the dose. Reading the Phase 3 results from Lilly today was encouraging. How many of you are on doses in the 9-12mg range? Seems like the various studies land there for best results.

I’m still on 1mg and I feel like I could go days with out eating… I’m tracking my calories and macros pushing to just eat enough each day.

 

[cookieguggleman]

Food noise and appetite are two entirely different things for me.

Food noise is mental. Appetite is physical.

Same. The noise is the compulsive/addiction part. And the appetite is the physical and natural part.

Food noise is not mental. Its exactly the same hormones in play. You are just trying to imply that some hunger is more legitimate based on how you respond to it or what time of day it happens.

Food noise is not mental. It’s exactly the same hormones in play. You are just trying to imply that some hunger is more legitimate based on how you respond to it or what time of day it happens.

I disagree and most psychologists would as well. Food noise is the chatter that happens in peoples heads that have compulsivity and/or addiction issues. It’s a really common Symp of it. It’s a form of dissociation, to spin out about something, anything. It’s different than having physical hunger.

 

[MsGizmo]

Same. The noise is the compulsive/addiction part. And the appetite is the physical and natural part.


I disagree and most psychologists would as well. Food noise is the chatter that happens in peoples heads that have compulsivity and/or addiction issues. It’s a really common Symp of it. It’s a form of dissociation, to spin out about something, anything. It’s different than having physical hunger.

Well, you know the old saying .. opinions are like assholes .. everyone has one.
Psychologists say its a mental issue to their customers.
Surgeons tell you they can solve obesity by cutting up your stomach and intestines.
Fitness trainers say you just have to exercise more.

 

[miss-sanne]

Food noise is not mental. Its exactly the same hormones in play. You are just trying to imply that some hunger is more legitimate based on how you respond to it or what time of day it happens.

yes, i agree, i have food noise because of metabolic dysfunction. it's not mental.
Correcting the metabolism, helped me.
I followed ' the binge code' , because i was told from society, from psychologists, etc, that i was flawed and needed to correct this in therapy. I did do a lot of therapy, did it help, no.
'the binge code' really turned it around for me, but correcting my metabolic dysfunction worked the best.

 

[miss-sanne]

Only ate half my lunch yesterday and didn't finish my dinner today. Odd for me.
I'm on week two. I don't "feel" anything but, I'll attribute it to the Reta.

Curious to see how it goes as I increase the dose. Reading the Phase 3 results from Lilly today was encouraging. How many of you are on doses in the 9-12mg range? Seems like the various studies land there for best results.

I'm on 8 mg now split dose, can't do once weekly, it gives me anhedonia.
It works well, well on appetite, no other side effects.
On reta I'm really hungry, and hunger is normal also on glps, but I just don't eat so much.
I'm blown away about the the new results.

 

[scarywood75]

Only ate half my lunch yesterday and didn't finish my dinner today. Odd for me.
I'm on week two. I don't "feel" anything but, I'll attribute it to the Reta.

Curious to see how it goes as I increase the dose. Reading the Phase 3 results from Lilly today was encouraging. How many of you are on doses in the 9-12mg range? Seems like the various studies land there for best results.

Always use the smallest effective dose and this applies to everything pharma.

Of course they'll try to sell higher dose, its in their interest, not yours

I am on 6mg every 2 weeks (in maintenance for the last 8 months). But the max i took is 7mg weekly and I lost 60lb total in less than 2 years.

 

[Calm Logic]

Exactly. Take the max dose so you have to have more visits to the doc and buy more meds for the sides. Greater but diminishing returns per their own studies. @ZippityDooDah has a great post on packing patience.