Stopping GLP-1 Drugs Triggers Weight Regain 4x Faster Than Ending Exercise

trojanpeptide

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I wonder if it depends on how long you are on it. At this point I've been on glp1s for almost 3 years. I've gone at least 4 weeks without any glp1s and my eating and weight stays the same. However, I think if I would have stopped after 6 months I probably would have gained everythng back and then some.
 
"Weight regain faster after stopping weight loss drugs than after dietary weight loss programmes."

I don't find this at all surprising or an indictment of the effectiveness of glps.
Weight loss through diet and exercise involves forming new habits and massive lifestyle changes. It would only make sense that slacking off on exercise or a diet plan will result in a more gradual reversion, while stopping glps without having made any other lifestyle changes will be a lot more abrupt.

Maybe I'm misunderstanding something though. The article didn't get into the weeds with the participant data.

I'm curious to see the results from people who combine glps with diet and exercise, and maintain the latter two after stopping the peptides.
 
When you come off any diet. You’re looking at the same stats. Weight watchers, keto, carnivore, paleo. Go back to your previous routines and you’ll go back to your previous weight.
I wonder what the true stats are on say for example WW for regain. My sister used WW many years ago and lost about a 150lbs in 2 years and then we had a death in our family and she gained 175lbs back in almost a year, like shockingly fast.

My sister is now on a glp1, has lost 220+ from her highest and is like 5lbs away from not being obese for the first time in her life. She will probably be on a glp1 forever, as I will too. Our whole family has dealt with obesity.
 
"Weight regain faster after stopping weight loss drugs than after dietary weight loss programmes."

I don't find this at all surprising or an indictment of the effectiveness of glps.
Weight loss through diet and exercise involves forming new habits and massive lifestyle changes. It would only make sense that slacking off on exercise or a diet plan will result in a more gradual reversion, while stopping glps without having made any other lifestyle changes will be a lot more abrupt.

Maybe I'm misunderstanding something though. The article didn't get into the weeds with the participant data.

I'm curious to see the results from people who combine glps with diet and exercise, and maintain the latter two after stopping the peptides.
I can't find the study, but I recall a study from maybe 20 years ago about who were the small percentage of individuals who kept the weight off. The conclusion, as I recall, is that the few who kept the weight off rearranged their whole lives around the concept of maintaining their weight. They were laser focused and nothing else mattered. Not work. Not family. Nothing. Dinner out with the family and blow the calorie budget -- nope. A family event that interfered with the workout -- nope. Take a job with time commitments that interfered with the weight loss lifestyle -- nope.

I don't think I could live like that if I wanted to. And I don't want to.
 
There's a saying that goes: You can't outrun a bad diet.
The idea is that you can't lose significant weight from exercise alone. You have to fix your diet!

Makes sense that the reverse would hold true and reverting to your old diet would lead to much faster weight gain than reverting to your sedentary behavior.
 
There's a saying that goes: You can't outrun a bad diet.
The idea is that you can't lose significant weight from exercise alone. You have to fix your diet!

Makes sense that the reverse would hold true and reverting to your old diet would lead to much faster weight gain than reverting to your sedentary behavior.
I haven't heard that one, but i have heard " You cant outrun your fork" lol
 
It seems like the news media loves telling this story. I think it's all part of our society's facsination/obession with fat shaming, as if obesity is not a disease for some people but a lifestyle choice.... And that glp-1 are somehow "cheating".

I don't recall Lilly or NN ever saying that these medications were a cure for obesity. 🤷🏻‍♂️
 
Newer study declaring what we already know...

Stopping weight loss drugs linked to weight regain and reversal of heart health markers

Average regain is 0.4kg/month and all weight lost likely to be regained in under 2 years
Weight regain faster after stopping weight loss drugs than after dietary weight loss programmes
I think this holds true for all weight loss because the problem isn’t the drugs. The problem is we live in very glutinous times with convenience being less expensive and more accessible than back in the olden days of food is fuel for survival. My friend got bypass and changed nothing in here life that would insure her results are permanent as did my sister. The mindset is, food is for rewards and involved in every occasion. It’s a scary fact not forcing a scientifically proven lifestyle change causing the results being short lived. The drugs/surgeries provide the body tools, and us forced discipline. The discipline is what’s needed on our end to carry the success in the long run. And I’m no saint or have mastery over my relationship with food. It’s a long process to reframe this aspect paired with accountability. You’ll also find transfer addiction. Usually alcohol/nicotine. (Both sister and friend rely heavily on those) and admittedly so. my vape is basically my adult pacifier. And that’s because I’ve not mastered discipline or gained control of my Brain yet. (Something I’m working on) but yes. The progress will revert and results will diminish but not because of the drugs. Big Pharma and healthcare wants us fat and unhealthy. And they can eat a bag of eggplants. Because over my dead body will I ever be the fat friend. I love it over here on the skinny side of life. Skinny privilege for girls (like me) is the same for men along side muscle privilege. Probably more so muscle privilege because it highlights commitment, control, and discipline.
 
This is just physics. Exercise really only burns so many calories; it is woefully deficient when it comes to weight loss when compared to calorie deficits, which is what GLPs are good at creating. Nothing new here, just silly headlines to make people scared.
I "discovered" this when I was losing a lb a day. Just fasting. ZERO exercise. 21 days without food. That was 10/23. I've been on a journey since then of discovering what I've been told about diet and exercise is all bs. Only I can control what I become. No one else is responsible for what goes in or comes out.
YMMV
 
I "discovered" this when I was losing a lb a day. Just fasting. ZERO exercise. 21 days without food. That was 10/23. I've been on a journey since then of discovering what I've been told about diet and exercise is all bs. Only I can control what I become. No one else is responsible for what goes in or comes out.
YMMV
Agreed 1000% It is however a big distinction. My spouse and I are both on GLP1s but our approach is different. We've lost the same amount of weight but I'm using a body comp scale daily to monitor fat % loss vs lean/muscle gain %.

At the end of the day I'm working out daily and I'm seeing almost 8% fat mass loss and 7ish% lean/muscle gain. She has lost both evenly.

We both show the same delta on weight but end result is huge in body comp!
 
Agreed 1000% It is however a big distinction. My spouse and I are both on GLP1s but our approach is different. We've lost the same amount of weight but I'm using a body comp scale daily to monitor fat % loss vs lean/muscle gain %.

At the end of the day I'm working out daily and I'm seeing almost 8% fat mass loss and 7ish% lean/muscle gain. She has lost both evenly.

We both show the same delta on weight but end result is huge in body comp!
I don't think anyone is suggesting you shouldn't work out. There are huge benefits that come from it! Just that there are a lot of people in denial in regards to their diets who think that if they start hitting the gym that will make up for a bad diet. It won't.
 
I don't think anyone is suggesting you shouldn't work out. There are huge benefits that come from it! Just that there are a lot of people in denial in regards to their diets who think that if they start hitting the gym that will make up for a bad diet. It won't.
No doubt. Especially when they grab a 500 calorie smoothie on the way out of the gym!
 
I mean it's no different really than yo-yo dieting. I've seen my mom loose a bunch of weight and regain it all multiple times throughout her lifetime. I think for some people, the temptation of bad food is simply too strong and whether they achieved their weightloss with a diet and pure willpower, or a semi forced diet and the assistance of a GLP-1, either the will power fades after dieting for so long or the safety wheels from a GLP-1 get removed, and it all falls apart.

I'm starting to wonder whether there is a huge genetic component to appetite and satiety. Some people are just genetically advantaged with minimal appetite and rapid onset of satiety. And maybe GLP-1 peptides are just the great equalizer.
 
Did your eating or exercise habits changed? You would obviously gain weight if your caloric intake is more than your maintenance for a period of time.
Yes my eating habits changed. The food off switch was broken again. Exercise habits stayed the same: Swimming more than 6 miles per week and hiking 1000 foot ascent hikes 1 or 2 x per week. Sprinkle in a little cycling and weight training. You are correct the caloric intake drastically increased.
 
I wonder if it depends on how long you are on it. At this point I've been on glp1s for almost 3 years. I've gone at least 4 weeks without any glp1s and my eating and weight stays the same. However, I think if I would have stopped after 6 months I probably would have gained everythng back and then some.

My goal is to develop better habits overall so when I take breaks from it I won’t go bananas. Your theory of time on the meds may have merit. Maybe you’ve adopted better habits.
 
The people I see who say they've gained weight back and then some, all have the same issue of constant hunger after starving themselves to their goal weight.

Me personally, I've been reducing my doses so I have hunger. I don't want to go throughout the day not feeling genuine hunger, or struggle to get my macros in.
 
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