Sublingual?

[Think]

Has anyone tried administering semaglutide sublingually? With certain permeation enhancers it is supposedly available this way. I am allergic to benzyl alcohol so multi dose vials have been out of the question for me for a while.

 

[PopTart]

I have not. Have you considered Orforglipron tablets? Uther sells them and they’re gaining popularity in the grey market.

 

[chmuse]

Has anyone tried administering semaglutide sublingually? With certain permeation enhancers it is supposedly available this way. I am allergic to benzyl alcohol so multi dose vials have been out of the question for me for a while.

Plenty of our UK members use sterile water because they can't get bac. So I'd also consider still using the semaglutide, just in smaller vials- I've seen as small as two mg.

 

[miss-sanne]

It hasn't been tested, so impossible to know.

 

[lessthanhalf]

Orforglipron sounds like the best idea.
Without spending hours on research, intranasal would make more sense than sublingual. I know it is often used with peptides like semax, and I did see a scientific study about intranasal insulin to treat alzheimer's recently. So I assume peptide/protein absorption is reasonable, but would be worth researching properly or even just asking gpt5/scholar about intranasal peptide absorption. Would be hard to know what dose you are getting, and would require a low starting dose and careful increases and would almost certainly start absorbing faster than s/c so might cause more nausea immediately after a dose. And your brain might get a higher dose than with s/c. Using plain water to reconstitute would be less of an issue for intranasal doses.
Or just buy 5mg semaglutide vials and use one dose, and throw the rest, using plain water for injections- about $5/dose but still very cheap compared to the shop version, and cheaper per month than most pharmaceuticals.
I was going to ask Can you be allergic as such to benzyl alcohol?, as it is a small molecule to be allergic to, but apparently it is possible.

 

[chmuse]

Orforglipron sounds like the best idea.
Without spending hours on research, intranasal would make more sense than sublingual. I know it is often used with peptides like semax, and I did see a scientific study about intranasal insulin to treat alzheimer's recently. So I assume peptide/protein absorption is reasonable, but would be worth researching properly or even just asking gpt5/scholar about intranasal peptide absorption. Would be hard to know what dose you are getting, and would require a low starting dose and careful increases and would almost certainly start absorbing faster than s/c so might cause more nausea immediately after a dose. And your brain might get a higher dose than with s/c. Using plain water to reconstitute would be less of an issue for intranasal doses.
Or just buy 5mg semaglutide vials and use one dose, and throw the rest, using plain water for injections- about $5/dose but still very cheap compared to the shop version, and cheaper per month than most pharmaceuticals.
I was going to ask Can you be allergic as such to benzyl alcohol?, as it is a small molecule to be allergic to, but apparently it is possible.

Just want to clarify that plain water is NOT tap water.

It’s crucial to use sterilized water in nasal irrigation

Whenever you talk about neti pots, you include a warning about always using distilled water. It seemed to me like an overreaction, but now there’s news that someone died from not doing that. Why would that be, when drinking water is treated and goes through testing?

share.google