Where did you generate the Active Med graph? Isn't the half life of Eloralintide longer than the usual for most peps?
Technically Possible To Combine Reta/Tirz w/ Eloralintide?
- Thread starter Spork
- Start date
Peter hinted in an interview that he's tested another sample of eloralintide from another manufacturer, but didn't disclose the name. Hopefully we'll figure out who soon.
dndgeek
GLP-1 Apprentice
Changsa has it in production
SoCalGirl
GLP-1 Novice
🚫No Source Discussion🚫
Oh, cool! I have NOT seen reta/cagri yet - that's my fave! The search is ON! 😁
chewonmysac
GLP-1 Enthusiast
It is 14 days. My app actually had it preloaded. Kinda wild. Regimen.
chewonmysac
GLP-1 Enthusiast
First, I wanted to say thanks for all the prayers from my fellow Freaks!
Update week 2. Took 2nd dose yesterday. 1 mg again. As you can see with the 14-day 1/2 life, the medicine has increased. The level of saturation will only increase. The half-life is twice the weekly dosage. No other GLP has this long a half-life. I have tried to time this 2 days prior to my normal weekly Tirz (15mg) shot. Again this week, those days the food suppression, which normally fades, has been suppressed. I am eating because I have to hit my Calories. Yesterday, I noticed an 8-point uptake in RHR. That has subsided. The thirst and dry mouth remain but have reduced. All is good. If stacking low and slow is the move. Down 3 lbs in the last 10 days. At this stage (13 months), that number is well above average, as my weight loss has come to a crawl.
Update week 2. Took 2nd dose yesterday. 1 mg again. As you can see with the 14-day 1/2 life, the medicine has increased. The level of saturation will only increase. The half-life is twice the weekly dosage. No other GLP has this long a half-life. I have tried to time this 2 days prior to my normal weekly Tirz (15mg) shot. Again this week, those days the food suppression, which normally fades, has been suppressed. I am eating because I have to hit my Calories. Yesterday, I noticed an 8-point uptake in RHR. That has subsided. The thirst and dry mouth remain but have reduced. All is good. If stacking low and slow is the move. Down 3 lbs in the last 10 days. At this stage (13 months), that number is well above average, as my weight loss has come to a crawl.
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lessthanhalf
GLP-1 Specialist
I had a look at the eloralintide papers yesterday, and found the half life info confusing. At all doses tested from 0.1mg to 12mg the half life was about 2 weeks but at doses of 1-4.5mg the half life was about a week. This does not really make a lot of sense, it is not impossible for drugs to have complex pharmacokinetics with different rates of decay at different doses, but I could not make sense of what the practical real world half life was, except probably a week at least at lower doses. Hopefully some bigger studies will clear this up, or I am misreading something. Obviously the people doing that app think it is 2 weeks.
Also found the weight loss did not look like it was anywhere near plateau at 48 weeks, so max weight loss for elora is likely to be better than the numbers seen so far, and in rats at least it had better lean mass preservation than cagrilintide, especially at lower doses. ( high doses tended to make them eat nothing for a week which might explain this effect being different at high doses.)
Also found the weight loss did not look like it was anywhere near plateau at 48 weeks, so max weight loss for elora is likely to be better than the numbers seen so far, and in rats at least it had better lean mass preservation than cagrilintide, especially at lower doses. ( high doses tended to make them eat nothing for a week which might explain this effect being different at high doses.)
