Clinical trials have shown that telmisartan increases insulin sensitivity, reduces cardiac fibrosis and hypertrophy, and improves endothilial function; all these effects can be attributed to its activity on PPAR-γ.
Side Effects
Side effects include
tachycardia and
bradycardia (fast or slow heartbeat),
hypotension (low blood pressure) and
edema (swelling of arms, legs, lips, tongue, or throat, the latter leading to breathing problems).
Allergic reactions may also occur.
Interactions
Due to its mechanism of action, telmisartan increases blood
potassium levels. Combination with potassium preparations or
potassium-sparing diuretics could cause
hyperkalaemia (excessive potassium levels). Combination with
NSAIDs, especially in patients with impaired kidney function, has a risk of causing (usually reversible)
kidney failure.