Time for a Reset

[Sasquatch]

I knocked off for the month of April. Gonna start again at the first of the month.
Just got tired of the shit. Big dosage doesn't mean I can't break through it. I just want to eat without nausea. Just got back from an enjoyable vacation. Wouldn't have been on tirz. Then not really loosing weight either.
I'm gonna start back at 19.5÷4=4.8mg. If it's too much I'll dilute it down more. Later

 

[FRMN01]

Don't know what to say. Keep us posted. WTF do I know? I may not be real 😂

 

[amosmylove]

I'm curious if others have an opinion/insight to this as it pertains to your post. I was thinking about it yesterday after reading some a post on reddit where the comments were kind of berating the poster for saying she was stopping her doc prescribed mounjaro (her dose was 7.5mg) because she felt so yucky and they were dog piling her saying she never should have stopped and she'll have to start at 2.5mg again and it probably won't work anyway now because her body had already gotten used to it and yada yada. I'm wondering how much of that is legitimate fact and how much is pharma putting it forward so that they never lose a patient paying monthly for max doses. They'd lose a lot of money if they came out and said tirz is still effective if used as a yo-yo method of weight control for those who don't want to build resistance or pay for it monthly at max doses.

 

[Sasquatch]

I'm curious if others have an opinion/insight to this as it pertains to your post. I was thinking about it yesterday after reading some a post on reddit where the comments were kind of berating the poster for saying she was stopping her doc prescribed mounjaro (her dose was 7.5mg) because she felt so yucky and they were dog piling her saying she never should have stopped and she'll have to start at 2.5mg again and it probably won't work anyway now because her body had already gotten used to it and yada yada. I'm wondering how much of that is legitimate fact and how much is pharma putting it forward so that they never lose a patient paying monthly for max doses. They'd lose a lot of money if they came out and said tirz is still effective if used as a yo-yo method of weight control for those who don't want to build resistance or pay for it monthly at max doses.

You can quote my opinion or not, but Facebook and reddit are almost like anti-reality.
Personally, I'm going to find out in real life what happens. Not too worried.
I know two folks, personally, one being a doctor, that never have gotten to max dose and decided to coast. IOW, only pinning when they felt like it. Doc and I had a similar starting weight, and loss. But he's for lack of a better description, softer tissued. He doesn't work outdoors, nor is his daily labor physical. Best thing is I can soon make a 30days worth suddenly 120days worth. Yet have dosage control spanning the entirety.

 

[amosmylove]

You can quote my opinion or not, but Facebook and reddit are almost like anti-reality.
Personally, I'm going to find out in real life what happens. Not too worried.
I know two folks, personally, one being a doctor, that never have gotten to max dose and decided to coast. IOW, only pinning when they felt like it. Doc and I had a similar starting weight, and loss. But he's for lack of a better description, softer tissued. He doesn't work outdoors, nor is his daily labor physical. Best thing is I can soon make a 30days worth suddenly 120days worth. Yet have dosage control spanning the entirety.

I'm of the same opinion/ mindset as you. Couldn't agree more about many sites being anti reality! Not to mention pharma hands out all the koolaid that they're drinking.

 

[Grogu]

I knocked off for the month of April. Gonna start again at the first of the month.
Just got tired of the shit. Big dosage doesn't mean I can't break through it. I just want to eat without nausea. Just got back from an enjoyable vacation. Wouldn't have been on tirz. Then not really loosing weight either.
I'm gonna start back at 19.5÷4=4.8mg. If it's too much I'll dilute it down more. Later

There really isn't a lot of science on the cycling of glp-1 mediciations, so we're largely left to anectdotal accounts. But from what I've read across numerous posts is some compelling stories that the subsequent restarting of glp-1s after a break isn't optimal. And that higher doses of medication are often needed to achieve results. Of course, this is in a capacity of actively trying to lose weight and not in maintenance. I would imagine that breaks while on maintenance are less of an issue.

There is this recent press release about a study, albeit a rat study at that, but it provides some idea that stopping and starting may make glp-1s less effective.

Stopping and Restarting Certain GLP-1s to Lose Weight May Make the Drug Less Effective | Newswise

Inconsistent use of some GLP-1 weight-loss medications, like Ozempic and Wegovy, may significantly lessen their effectiveness, according to a new preclinical study.

www.newswise.com

It will be interesting to see how things go as you progress. Please let us know.

 

[Calm Logic]

But from what I've read across numerous posts is some compelling stories that the subsequent restarting of glp-1s after a break isn't optimal. And that higher doses of medication are often needed to achieve results.

Of course, correlation is not causation, so makes me wonder why they took a break to begin with. I have experienced the opposite, if anything.

 

[tubby]

I'm wondering how much of that is legitimate fact and how much is pharma putting it forward so that they never lose a patient paying monthly for max doses.

As a Lilly shareholder, I vote that we burn the heretic who skipped a dose!

 

[myopicmystic]

I knocked off for the month of April. Gonna start again at the first of the month.
Just got tired of the shit. Big dosage doesn't mean I can't break through it. I just want to eat without nausea. Just got back from an enjoyable vacation. Wouldn't have been on tirz. Then not really loosing weight either.
I'm gonna start back at 19.5÷4=4.8mg. If it's too much I'll dilute it down more. Later

could you split dose? maybe split your weekly dose into two injections 3-4 days apart would help reduce the nausea

 

[Mr. Blonde]

Do what you think is best for you. There are people on here that swear by "Doctors" that are actually just chiropractors who aren't even allowed to do massages any more, but they spew their nonsense on YouTube and people buy into it hook, line, and sinker.

 

[Sasquatch]

could you split dose? maybe split your weekly dose into two injections 3-4 days apart would help reduce the nausea

I've been pinning 15mg, then an additional 4.5mg 36hrs. later.
It's not that kind of nausea. It's the kind you get when you been high-balling tirz., then you eat something more than a kid's burger patty. I was not allowed to fast, tho I wanted too. So I got this nagging over-full feeling alll the time.

The plan is to start back at 2.5mg. But I know what I striving for "feeling" wise. Easy enough to double up to 4.5 or 5mg.
Like I said. We shall see. Of all these explorers here on the site, nobody ever just quit for 30 days, really? I get it. If I had a freezer full of different flavors, the first thing would be to change.

 

[myopicmystic]

I've been pinning 15mg, then an additional 4.5mg 36hrs. later.
It's not that kind of nausea. It's the kind you get when you been high-balling tirz., then you eat something more than a kid's burger patty. I was not allowed to fast, tho I wanted too. So I got this nagging over-full feeling alll the time.

The plan is to start back at 2.5mg. But I know what I striving for "feeling" wise. Easy enough to double up to 4.5 or 5mg.
Like I said. We shall see. Of all these explorers here on the site, nobody ever just quit for 30 days, really? I get it. If I had a freezer full of different flavors, the first thing would be to change.

Ah, yeah other than splitting the dose evenly to 10mg twice weekly, I wouldn’t know what to do there - you’ve been down this road longer than I have. So I hope the reset works for you and let us know how it turns out!

I think taking a month long break depends on what stage the person is at. If they’re still in active weight loss or far from goal, I think the worry with a break would be that it won’t work as well when they resume. So based on what I’ve read here, it’s more likely they’d add on something or transition to a new med. But, in maintenance, you read about people extending time between injections to 2-3 weeks and still maintaining okay.

 

[domin8brix]

Do what you think is best for you. There are people on here that swear by "Doctors" that are actually just chiropractors who aren't even allowed to do massages any more, but they spew their nonsense on YouTube and people buy into it hook, line, and sinker.

Or pharmacists.

 

[Sasquatch]

Well, 1st of the month I started back on 2.5mg. And all this jibber-jabber made me pin another 2.5mg the next day.
Adequate hunger suppression. And the usual punishment for over-eating. Won't step on the scale until mid-week.
That's changing a weeks worth, into a month's worth. I'd be happy to go all summer like this.

 

[ColdSmoke]

To piggyback on myopic’s take; there’s a lot of anecdotal evidence that going off and on GLP-1s makes future weight loss (the journey) more difficult. I had the same experience as you when I went up to 10mg, but I titrated too fast (every month). I went back down to 7.5 for like six weeks and now I’m back up to 10 because my food decisions were less that optimal. It seems like you just need to dial in the dose that works for you… the lowest tolerable dose that results in steady weight loss. Even 1/2 pound a week equals 26lbs down in a year. It’s a marathon

 

[thatkatmat]

Well, I'm stopping, just reached goal weight, taking a break while I travel for a month. Been on 9mg's Tirz, lost 65 lbs. Will be interesting to see how I feel around food and how my mood and desires for life are after 6 months on Tirz. I'll start back up when I'm back, thinking I'll start at 2.5 and see what happens.

 

[Sasquatch]

Well, I'm stopping, just reached goal weight, taking a break while I travel for a month. Been on 9mg's Tirz, lost 65 lbs. Will be interesting to see how I feel around food and how my mood and desires for life are after 6 months on Tirz. I'll start back up when I'm back, thinking I'll start at 2.5 and see what happens.

Caution! It is a mindset. I live amoung what I call a buffet culture. We typically eat big steaks, and salad bar and potatoes with cheese and onions on top. And consume cocktails. Just like a sixties movie. Many also smoke! We aren't going to live to 100 unless we're cursed. Fucking right, one will gain weight back if one goes back. I was smiling as I was describing the culture. It's indulgence. The opposite of a struggle. The struggle I have now with the last 20lbs. My gut biome has always argued and won. GLP1's has given me ammunition. But the gut fights back. Still don't know how it will turn out? 60lbs. down may be it?