Tirz curing anxiety?

c137junk

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I started Tirz over 2 years ago now and I used to have pretty bad anxiety due to a medical episode I had. Like lay awake at night unable to sleep kind of anxiety.
About 2 weeks after I started Tirz it basically disappeared and I've been 99.9% anxiety free since then.

Has anyone else had Tirz cure their anxiety and if you stopped Tirz did the anxiety come back full force?
 
I think a little bit, although I don't suffer anxiety that often. But what I know for sure it has done is something quite remarkable. I'm 59 yrs old and been smoking weed since I was about 15...Over the last 30 years I've I quit cigarettes, hard drugs and really slowed down to like a beer or 2 a month (when out with friends) but NEVER had it in me to quit smoking weed...
When I did try, I'd get major a$$-hole syndrome towards anything and anyone in my path. I started Tirz 3 months ago and quit smoking weed after the 2nd day. Don't want it, don't crave it, pretty sure I'll never use it again. Tirzepatide has changed my life in so many positive ways!!

Congratulations on your overcoming anxiety, that's HUGE and just another positive outcome for this miracle peptide!
 
While I am on the cusp of the beginning to the start of my reta treatment, finding information like that gives me hope. Even though it may be a psychosomatic, internal stress has to come from somewhere, and I would take comfort with possibly not knowing its origin but feeling it ease.

I have suffered with varying degrees of GAD for most of my adult life. Although I do not expect this medication to alleviate that for me, if my body starts to feel better due to weight loss from my current obese state, I will ride that feeling as far as I can. And you should too.

Sorry this isn't much of an answer. But you should feel good because you're starting to feel good.
 
Has anyone else had Tirz cure their anxiety and if you stopped Tirz did the anxiety come back full force?

As amazing a medication as tirzepatide has been for many, I’m not sure that it’s a “cure” for anything. What we know scientifically right now is that the medication is an effective treatment for certain underlying metabolic conditions (mainly obesity and diabetes), and that the medication can also be helpful for conditions like BED, alcohol use disorder, OSA, osteoarthritis. other addictions, etc.

Unfortunately, the medication treats these conditions and is not a cure for any of them. So, I think if you stop taking the medication that your symptoms of anxiety are likely to return. Much like we know that when people stop tirzepatide they gain some of the weight back over time. So, I’m not sure why we’d expect anything different for these other conditions. The symptoms are likely to return. in your case, the anxiety.

What I’ve done (just in case for some reason I can’t stay on the medication the rest of my life or it loses it’s effectivenes) is that I’ve been working on some of the psychological and nutritional issues that gave rise to my issues with food. It’s tough work. But, I found a really great therapist and a nutritionist and both have been a tremendous help.
 
Later in the week I get hungry. But tirz is a trainer. I know if I eat anything more than a measuring cup full of anything, I'm gonna be sorry.
Not ness. anxiety, but I've heard reta messes with sleep. I gonna start a microstack of reta soon. Maybe .5mg.
 
I started Tirz over 2 years ago now and I used to have pretty bad anxiety due to a medical episode I had. Like lay awake at night unable to sleep kind of anxiety.
About 2 weeks after I started Tirz it basically disappeared and I've been 99.9% anxiety free since then.

Has anyone else had Tirz cure their anxiety and if you stopped Tirz did the anxiety come back full force?
Yes. Tirz stopped my anxiety almost entirely. Did the same for my girlfriend. I recently switched to reta for the liver fat loss and have had some anxiety since. Not alot though.
 
I usually carjack a forklift at Home Depot to check my anxiety levels, haha.

But tirz did not seem to help my anxiety very much. Haven't tried Selank or Semax yet.

SSRIs and SNRIs are top-down option compared to GLPs, at least for neuroinflammation:

Google Gemini said:
Screenshot 2026-01-07 085526.png
"Top-Down" vs. "Bottom-Up" Approach

SSRIs/SNRIs (Top-Down): These work largely from the nervous system outward. By calming the brain's "alarm system" (the microglia), they stop the brain from sending inflammatory signals to the rest of the body.

GLP-1s (Bottom-Up): These work from the metabolic system inward. By fixing high blood sugar and reducing visceral fat (which is itself an inflammatory "organ"), they remove the source of systemic inflammation that eventually reaches the brain.

Trying Pristiq again now for shits and giggles. And exercise has always been a good thing for my brain.
 
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Yes. Tirz stopped my anxiety almost entirely. Did the same for my girlfriend. I recently switched to reta for the liver fat loss and have had some anxiety since. Not alot though.
Did you switch cold turkey or are you stacking reta/tirz? I'm currently stacking both, I've dropped down to 11mg Tirz and up to 4mg reta and so far still no anxiety.
 

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