Tirz dosage equivalent of Sema .5 ?

[HB_22]

Not everyone is ready to move from CPs to CHINESE research peptides
to be sure! And that would be necessary to save money vs the best compounders.

Even CPs are sourcing their peptides from China. There is no difference.

 

[milos]

Even CPs are sourcing their peptides from China. There is no difference.

yes, perhaps there is just a more quality control

 

[zpped]

This is confusing to me. I do realize the different mechanisms of action for the different peptides, but, for me anyhow, I don't see how NOT having my appetite suppressed would equate to MORE weight loss. Does it boost your metabolism so much that even eating more you lose weight? I guess this is why some stack these together, top get both benefits... but I thought T was just basically S with a 3rd mechanism of action - so to speak, in terms of mechanisms of action... and that, for example, adding cagri gives sema that 3rd mechanism.

I'm very curious because I know that sema will stall at some point, so I'm trying to put together a plan for when that happens.

Sema is glp1
Tirz is a different glp1 and gip
Reta is Tirz+glucagen
Cagri is amylin

The glp1 in tirz activates much weaker than the one in Sema (which is why the dosage is 7-10 times higher)

Tirz doesn't suppress appetite as much but that doesn't mean the subject eats more. They feel hungry, and then they feel full quickly.

 

[milos]

Sema is glp1
Tirz is a different glp1 and gip
Reta is Tirz+glucagen
Cagri is amylin

The glp1 in tirz activates much weaker than the one in Sema (which is why the dosage is 7-10 times higher)

Tirz doesn't suppress appetite as much but that doesn't mean the subject eats more. They feel hungry, and then they feel full quickly.

its actually much more complex and it is absolutely not only about "eating less"
some reading, for example, is here:

Frontiers | GLP−1 receptor agonists for the treatment of obesity: Role as a promising approach

Obesity is a complex disease characterized by excessive fat accumulation which is caused by genetic, environmental and other factors. In recent years, there ...

www.frontiersin.org

 

[dionysos]

Even CPs are sourcing their peptides from China. There is no difference.

@HB22
Of course they are! That is not what we are talking about.
The discussion is about COST not differences in the supplied medication.

 

[zpped]

its actually much more complex and it is absolutely not only about "eating less"
some reading, for example, is here:

Frontiers | GLP−1 receptor agonists for the treatment of obesity: Role as a promising approach

Obesity is a complex disease characterized by excessive fat accumulation which is caused by genetic, environmental and other factors. In recent years, there ...

www.frontiersin.org

I wasn't trying to imply it was only "eating less", just that even though there is less appetite suppression doesn't mean they are are eating more. Obviously what I wrote is extremely simplified.

 

[YoYoFat]

Tirzepatide has far less appetite suppression than Semaglutide.

What about food noise or other cravings? Are they equal?

 

[Derby]

What about food noise or other cravings? Are they equal?

That seems to be very idiosyncratic. Some people swear that semaglutide is far superior, but I've also heard many success stories with tirzepatide. Food noise was always a very minor issue for me, but what little I had was resolved with 2mg 2x/week of tirzepatide.

 

[YoYoFat]

It’s not for me I have a friend who has been on Ozempic at .5 and that’s all that the VA will give them. They want to try tirz instead because Ozempic stopped working for them quite a while back and they cannot get the VA doctor to listen. All they did was give him massive amounts of metformin in addition to the Ozempic and he said he is sh-tting 10 to 12 times a day and every day that goes by he feels worse and worse. He knows there are advocates that he could contact, etc. but he’s old enough to find it easier to try to find a solution on his own.

The shitting of the pants is from the Metformin. No question. It’s almost impossible to avoid, unless on extended release. Most just prescribe immediate release. See if he can get on ER.

 

[YoYoFat]

That seems to be very idiosyncratic. Some people swear that semaglutide is far superior, but I've also heard many success stories with tirzepatide. Food noise was always a very minor issue for me, but what little I had was resolved with 2mg 2x/week of tirzepatide.

The suppression of food noise has been life changing for my RS.

It’s also suppressed other obsessive behaviors, like reckless shopping. And ADHD symptoms have improved.