Tirz to Reta exploration is NOT going well.

[tendency]

I would stay on tirz, and add in Reta, in a scale balancing manner, over time.. Lower tirz by 1mg, add in 1mg Reta.. I pin them separately every few days. The body needs time to adjust to new things, is my philosophy.

This is exactly how I switched from Reta to Tirz, no issues. Have to do a low and slow shuffle from one to the other.

 

[randompersonrandom]

This is exactly how I switched from Reta to Tirz, no issues. Have to do a low and slow shuffle from one to the other.

you know what, I think I'm gonna get out of my head and do this method both the rest of the way "there" to reta and then back when I switch back. Now that I type "I let a disgraced chiropractor YouTube bro get in my head about a fairly sane plan and now I'm in rough shape," I feel genuinely silly. You and @desinr-gal are right and this is dumb.

 

[joseblo]

Thank you for this. I'll think on it. That's very close to my dosage-switch that I'm looking at (8 of tirz to whatever-works-reasonably-well of reta), so it's helpful to hear that experience. And I've never had a single digestive side effect from tirz, survo, or reta, but gastroparesis has always sounded VERY scary.

Yeah, only time I've every had real gastro issues was the transition to reta.
I was really glad I was doing every 3 days rather than every day, since I was able to notice something was off before I kept increasing.

 

[BNLFL]

@randompersonrandom I have no advise on this subject as I've been Reta only for 3 months. My question, why the odd doses? 2.2, 4.4 and 6.6. Just curious.

 

[randompersonrandom]

@randompersonrandom I have no advise on this subject as I've been Reta only for 3 months. My question, why the odd doses? 2.2, 4.4 and 6.6. Just curious.

I never quit using the concentration I started with on compound, which is 22 mg/ml. That makes 10 units 2.2, 20 units 4.4, and so on up. I could adjust the concentration and the doses, but I never did get around to doing that; and the fact that I concentrate almost every glp1 the same and always have means I've never had to learn any new math for tirz and now reta. I'd have done it with survo too, but my starting and been-awhile dose for that were both so tiny.

 

[woundcarping]

Everyone has their own thoughts, here's my observations/experiences:

What was your Tirz dose?

I started Zep 12/12/25, I moved to compounded Tirz and was at 2.5mg 2x weekly until 1/10 when I moved to Reta. I took 7mg of Reta in total across 6 doses my first week. I've had 6 doses of Tirz since I started the bridge, totaling 14mg. I've had a total of 34 doses of Reta totaling 143mg. That averages 11.6mg/week with a chunk of that being getting my blood levels up using numerous small doses so I wouldn't overshoot and run into sides I had to wait out.

I moved to Reta for the GCGR signaling to boost BMR and presumptively spare lean mass better than Tirz.

GCGR signaling is dose dependent. Titrating Reta based on appetite/food noise is incorrect for reta, correct for Sema, Tirz, or Cagri. I titrated based on aversion to sides with the goal to get to or above 8mg/week levels for meaningful GCGR signaling.

I take Tirz PRN mainly to control food noise more so than hunger... my long term issue has been noise/brain side more than hunger/stomach side. I'll still take a bump if I expect the probability for trouble (like the 2.5mg dose in early March since I was traveling to either side of the country and back in 8 days).



Down 33lb since 1/10/25, 272lb to 239lb, practically all fat according to DEXA scans.
Had no meaningfully adverse sides.
Split dose, 2x weekly.
16mg/week with split dosing keeping my peaks only 15% higher than 12mg/once weekly (7mg 2x weekly has the same peaks).
RHR average hit a valley low of 58bpm on Tirz and is currently averaging 69-70bpm. This is inside my comfort level.

I don't expect 16mg to be magical over 12mg, but I do expect it to move my equilibrium point down ~10lb. That doesn't sound like much, but arguably that would be the hardest 10lb to lose. I chose to escalate my dose based on my sides and metrics including labs, fitness tracking, and sleep. I chose to do it now while I'm still resilient to the added stress vs later when systemic stress fatigue could be presenting.

Writing this post, I realized I failed to get labs on Lipase and Amylase to check my pancreas directly. My other labs suggest I'm doing fine, but gallstones/pancreatitis is my most likely hiccup. I'll get those labs drawn in the morning and report back if there's anything noteworthy.


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8mg/2x week is currently too much, I backed yesterday’s dose down to 7mg (14mg weekly).

Too much appetite suppression. More than transient lower gi symptoms, but manageable.

Down 4lb since that post from Monday, too much loss to sustain, but a one off isn’t a problem.

 

[john_askins]

i went from tirz 2.5mg EOD to reta 1mg every day. rebooted the feeling of being full after eating less but i'm always feeling hungry. starting to think i fell for the hype of reta when tirz was doing fine (though i did stall for 2 months and that's what got me to change). started losing weight again on reta so i'll stick it out for a bit. only been a few weeks. good luck to you

 

[5byfive]

I am planning to do a little experimenting with reta myself. On 5mg Tirz for food noise at maintenance/lean bulk. The plan is to add a little reta (.5 to 1mg) when its time to do a mini cut. My hope is instead of cutting calories I can just turn things up a little bit and hopefully maintain more muscle during the cut.

Based on everything I've read from people using both, it really seems like Tirz is more of an appetite suppressor and reta is more of a metabolism booster. Both can have both effects (Triz definitely boosted my calorie burn) but better to have the best tool for each job.

 

[randompersonrandom]

Just cause new people might run into this thread years from now and be frustrated because they didn't get to see the resolution; I upped to 5.5 mg and added back in 3.3 mg of tirz, and I am now not struggling. I hit 130 yesterday (I'm 5'5"), which is a new low. I'm still aiming for 125, but I'm not trying particularly hard, just trying to mind calories and bicycling to the gym to swim most nights.

 

[ThatNextGril]

Just cause new people might run into this thread years from now and be frustrated because they didn't get to see the resolution; I upped to 5.5 mg and added back in 3.3 mg of tirz, and I am now not struggling. I hit 130 yesterday (I'm 5'5"), which is a new low. I'm still aiming for 125, but I'm not trying particularly hard, just trying to mind calories and bicycling to the gym to swim most nights.

And you've not had any annoying sides from the reta? I sadly had to stop at 2.5mg twice weekly, as even with the 8mg tirz I was still on didn't stop the hunger brought on by dropping the tirz from 11-12mg. Those 7 weeks I was on reta was all crappy sides like upped HR, bad sleep, hunger, lively gut (pepto almost every day) and sometimes I minor headache. Stopped the reta, and within 2 weeks all was well again. I'm at 139 (I'm 5'9") so although the weight is totally within a good range, the fact that I can grab fistfuls of fatty thigh to pin every day speaks to the need for pushing through my now 3 month stall. I wish reta had played nice with me, but I had to swipe left.

 

[randompersonrandom]

And you've not had any annoying sides from the reta? I sadly had to stop at 2.5mg twice weekly, as even with the 8mg tirz I was still on didn't stop the hunger brought on by dropping the tirz from 11-12mg. Those 7 weeks I was on reta was all crappy sides like upped HR, bad sleep, hunger, lively gut (pepto almost every day) and sometimes I minor headache. Stopped the reta, and within 2 weeks all was well again. I'm at 139 (I'm 5'9") so although the weight is totally within a good range, the fact that I can grab fistfuls of fatty thigh to pin every day speaks to the need for pushing through my now 3 month stall. I wish reta had played nice with me, but I had to swipe left.

No, nothing; no sides, no "feelz," absolutely zero. If I found out later that I was injecting water, I'd be like "Oh, that makes sense." (I know that's a common sentiment and it's not water.)

 

[Lovedog100]

Dude's a fraud.
"Trevor Bachmeyer (born circa 1973) is an American former licensed chiropractor (license number DC 29377) whose license was revoked effective July 8, 2020..."

Trevor Bachmeyer — Grokipedia

Trevor Bachmeyer (born circa 1973) is an American former licensed chiropractor (license number DC 29377) whose license was revoked effective July 8, 2020, by the California Board of Chiropractic Exami

grokipedia.com

He reportedly likes to quote non-existent studies.

Bachmeyer has zero credibility with me. Another "I know more about (insert subject) than anybody" buffoon. The only credentials that he had, were revoked. Nuff said.

 

[RoadRash]

I've been on tirz since late June of '25, stacking a small dose of Survo against it since November or December with no intent to continue the survo in maintenance but wanting relief from fatigue. Lost almost all my excess weight and heading toward the end. Got ten years' worth of max dose tirz in my freezer, got mostly over my urge to hoard it because ok, that's enough to feel fairly un-anxious. Started slow-hoarding reta with no intention of actually using it for years, because I like meds that have been out in the general population for several years so we have real-world medium-term data, but figured there may come a time when I might want to switch in maintenance because people seem to love it so much. Got to three years worth, and said ok, hang on..it's fine that I don't want to be on it long term yet, but I should prolly try it for a few months and sacrifice a couple of vials to make sure it's even slightly ok for me, because won't I be disappointed someday if I decide to switch to it and find out it's terrible for me. Intend to titrate back down, switch back to tirz, and keep doing what I was doing when the two vials are up.

Last dose of tirz was 3/16. Started a 2.2 dose of reta. Got anxious, injected another 1.1, then another the next day, then another. Got ahold of myself, did 4.4 mg the following week, then 4.4 again. Didn't want to jump too high while I still had tirz overlap, or too fast because come on random, let's not screw around TOO much here.

Today's my shot day, and I could and maybe should do no more than 4.4 mg. If I do that this week and next week, then I'll probably be ok to titrate up after that. The trouble is, I'm a food monster over the last week. Sure, my period is coming and of course I'm hungrier, but Jesus, I'm ASHAMED of how much I ate yesterday. that feeling has been in my rear view mirror since last summer, so it's pretty scary to have that again.

I'm having no side-effects; I may as well be injecting straight bac for how the "feelz" are, which I know is such a common feeling with new reta users who have been on tirz. And I trust the source of my reta and it's well tested, I know it's not fake, this is just how it is at first for a lot of people and I'm one of them, ok. But I don't want to feel food obsessed. The three pounds the scale went up this week are almost certainly not fat, not with the amount of sugar and carbs I've been stuffing into my mouth and the upcoming period. It's water and ok. but it WILL be fat if I keep this up.

It's too soon to declare "oh, reta is no good for me," switch back to tirz, and stop stocking reta. I really want to give this a fair shot. But I'm open to suggestions on what to do next; stay at 4.4, go up to 5.5 or 6.6, or do something else. I feel like I've read this exact same experience dozens of times and the answer is almost always "you may not feel anything til you get to 8 mg" but I don't want to be hanging out out of control for months more when I'm super used to HAVING that control.

Tirz is much better for elimination of hunger. Reta, not so much but I found myself eating much cleaner and enjoying some of the other benefits of Reta metabolically.