Tirz Week 3

[drzoid614]

Hi all,

Id love to get some feedback and stories on everybody elses experience with Tirz and dosages.

I am about to start week 3 of tirz, with no prior experience with any GLPs. Im on 2.5mg (one injection per week) and my side effects are very minor, i just get nauseous/ acid reflex sometimes usually the day after injecting, but its manageable and i just take over the counter medication.

Im nearing 4 weeks which i have read is when many dose up to 5mg. But my appetite is still very surpressed and im really not eating like i used too. I am definitely not wanting to eat more and all the food noise has definitely quietened. I just havent noticed any weight loss. I exercise regularly.

Is it too early to be losing substantial weight? And also, should i dose up even if i think 2.5mg right now is still ok?

Id love to hear what others experiences have been and if anyone has gone through the same

Thanks

 

[msyntakz]

I started with 2.5mg Tirz and stayed on it for 4 weeks, and had sufficient suppression. Similar to what you are experiencing. However, I planned and proceeded to combine with Reta, as I am going to titrate up on that to get the Glucagon benefits, but really wanted the food noise suppression of Tirz. I added 1mg Reta. With that combo, it was another substantial step up in food noise suppression.

All that to say, I did not need to go up in Tirz. I just wanted to start the Reta titration. I will be holding here for a while, I assume. I started Tirz on March 30, and as of now, I am 20 lbs down. Largely water weight, I know, but definitely losing some fat.

Also, I track calories (1000 calorie deficit average), walk 5 miles a day minimum, and weight train 3-4 times per week. The GLP meds are giving me the mental space to implement the deficit needed for progress. Tracking every single little calorie, even if you sniff a ketchup packet, will give you the objective data to know why you are losing or not.

 

[lessthanhalf]

If you are not really hungry much , and already have some nausea on 2.5mg of tirz, then increasing it to 5mg will almost certainly increase the nausea significantly, it is a bit hard from your description to be sure how bad it is now so harder to predict how it might change from increasing the dose.
I do not know if you are using it to lose a little bit of weight or a huge amount, if trying to lose a lot you will definitely need to crank the dose eventually, but there is no reason to hurry. One option is simply see what happens from 5mg, if you start puking, then you know it is too much and go back to 2.5 and wait and go up much more slowly, or just increase it a bit to 3 or 3.5 mg. Side effects are usually the best guide as to whether increasing the dose will be a problem.

 

[Calm Logic]

It is a curious situation since the weight melted off for me in the beginning, before the inevitable stall. I was at my highest weight ever, and I was on an aggressive titration schedule with tirz, thanks to my oddball PCP. But some people lose 4+ pounds a week like I did but with just 1 mg of reta. And it's possible you may be having some body recomp (fat loss with muscle gain) or some other non-scale victories.

There are so many options in grey, you can go a little insane. So generally, sticking with the program is one way to stay sane (or have more side effects). With tirz, anything less than 5 mg a week is not considered a therapeutic dose per se. But a lot of people microdose, like if using GLPs just for optimization or minor weight loss.

My weight loss often coincides with side effects, so they are not inherently bad to me. I have various OTCs, in addition to Zofran, in case I need them, though they have only done so much for some rough rides. For heartburn, I used generic Voquezna from India. And I also take probiotics when I remember, in addition to drinking Kefir sometimes or eating sauerkraut.

To expand on @lessthanhalf, I would consider something like 2+ mg of tirz, twice a week (to raise the dose while managing sides). Or I would even consider adding/switching to reta already, as mentioned by @msyntakz. I love tirz and have plenty hoarded away. But most of my peptide friends are on reta, and I buy only reta now when buying GLPs to hoard.

 

[Zydeceltico]

Hi all,

Id love to get some feedback and stories on everybody elses experience with Tirz and dosages.

I am about to start week 3 of tirz, with no prior experience with any GLPs. Im on 2.5mg (one injection per week) and my side effects are very minor, i just get nauseous/ acid reflex sometimes usually the day after injecting, but its manageable and i just take over the counter medication.

Im nearing 4 weeks which i have read is when many dose up to 5mg. But my appetite is still very surpressed and im really not eating like i used too. I am definitely not wanting to eat more and all the food noise has definitely quietened. I just havent noticed any weight loss. I exercise regularly.

Is it too early to be losing substantial weight? And also, should i dose up even if i think 2.5mg right now is still ok?

Id love to hear what others experiences have been and if anyone has gone through the same

Thanks

When faced with this same self-created dilemma in the beginning (and still from time to time), I benefit from reminding myself that I am not in a race. 🙂 (Unless of course, you are but I kinda doubt it).

I'm pretty sure that the general agreement amongst the vast majority of us is that the lower the dose and the simpler the stack (or non-stack) for as long as possible/effective, the better for your overall well-being.

It is also less expensive to stay on as low a dose as possible while still losing weight.

Focusing on diet, exercise, and quality sleep (for real), is a - in my opinion - foundational and imperative adjunct to the meds.

 

[hoobz]

Is it too early to be losing substantial weight? And also, should i dose up even if i think 2.5mg right now is still ok?

Id love to hear what others experiences have been and if anyone has gone through the same

Hey there!

I'm finishing my 5th week on 2.5mg. I was considering upping the dose, but since it's working really well and appetite suppresion is great, I'm not going to for now.
I even have a feeling like this 5th week the suppresion is stronger than in week 3, which was probably when I felt the least of it. At the same time, the sides (nausea and tiredness mainly) subsided. I lost 5kg so far, exercising regularly too. I feel it's working, and until I do, I'm not changing anything 🙂

 

[GrandmaJ]

I tried increasing from 2.5 to 3.75 after 4 weeks while having some nausea still. Don't do it! Let the 2.5 build up in your system for another few weeks and then try a small increase instead of jumping straight to 5. If you are prone to side effects, going up just intensifies it.

 

[Maximus]

Hi all,

Id love to get some feedback and stories on everybody elses experience with Tirz and dosages.

I am about to start week 3 of tirz, with no prior experience with any GLPs. Im on 2.5mg (one injection per week) and my side effects are very minor, i just get nauseous/ acid reflex sometimes usually the day after injecting, but its manageable and i just take over the counter medication.

Im nearing 4 weeks which i have read is when many dose up to 5mg. But my appetite is still very surpressed and im really not eating like i used too. I am definitely not wanting to eat more and all the food noise has definitely quietened. I just havent noticed any weight loss. I exercise regularly.

Is it too early to be losing substantial weight? And also, should i dose up even if i think 2.5mg right now is still ok?

Id love to hear what others experiences have been and if anyone has gone through the same

Thanks

Tirz has been great for me. I've been at it for a year. I followed tdee-500cal as caloric intake until about 1500. If I dropped below that figure my energy would crater. My titration schedule increased when the food noise would return. I started at 2.5 and have been on 10 for the last 7-8 months. I began losing pretty much immediately. My overwhelming suggestion would be to track your food intake and titrate up when you find the food noise creeping back.

 

[Pin&Play]

The reason why these meds are designed to go up in dosage every month is that people are dumb and if the rule was 5 or 6 week, they would mess up all the time. 1 month is just easier to remember

(yes that's only my guess. But I think I'm right).

So my suggestion is to do whatever you think is right for yourself. And generally increasing the dosage when the med is working is NOT a good idea.

Especially because at week 4, you might not have reached the max levels in your body... so zero reasons to double it now.

As other said, a better move is titrate up slowly as soon as you feel the appetite suppression fading

 

[drzoid614]

The reason why these meds are designed to go up in dosage every month is that people are dumb and if the rule was 5 or 6 week, they would mess up all the time. 1 month is just easier to remember

(yes that's only my guess. But I think I'm right).

So my suggestion is to do whatever you think is right for yourself. And generally increasing the dosage when the med is working is NOT a good idea.

Especially because at week 4, you might not have reached the max levels in your body... so zero reasons to double it now.

As other said, a better move is titrate up slowly as soon as you feel the appetite suppression fading

This is really helpful and great advice. And honestly what i was thinking deep down.
Thanks!