therealdlg
GLP-1 Novice
🚫No Source Discussion🚫
All right fellow labrats...what are the pros and cons of 20 or even 25 MG weekly tirzepatide? Any studys on this?🤔🤔🤔🤔
Tirzepatide at higher dose?
- Thread starter therealdlg
- Start date
GLP-1 Novice
CNCCurrency
GLP-1 Specialist
Someone on here was doing 25 mg. Try doing a search.
Stace_wow
GLP-1 Novice
🚫No Source Discussion🚫
I was looking around for that too, I know one person is pushing 20mg but I haven’t found any articles on it….
spanky2026
GLP-1 Enthusiast
My understanding is Lily is doing studies right now, supposedly on 20 and 25mg dosing, but no results have been released or hinted at anywhere I've seen.
headward
GLP-1 Apprentice
Why not switch to reta + elora or start adding elora to max dose tirz? Elora kit is $170 on gb right now.
I saw some statistics on aGLP-1 overdose cases in U.S. emergency departments. About 18,000 people last year, if I remember well. Many of them took the entire pen instead of multi-dosing. Mostly issues with gastrointestinal blockages, gallbladder problems, etc. Some suffered long-term effects (you either die from it or go crazy: I know because I’ve been through it.../j)
There are two main reasons to increase the dose: it isn't working, or it isn't working fast enough.
The first case has an obvious solution: do something else. Personally, Tirz wasn't working very well, so I added Retatrutide. It turns out they complement each other.
The second case is impatience. That comes down to avidity. Always feeling empty. What a coincidence!
If you're eating a lot, it's worth taking a closer look at the wound that's making you feel empty.
There is a trick: the gratitude journal. Write a few lines every evening about what you notice you've received during the day. It works in 2-3 weeks. and it's much cheaper than a session with a therapist. And there's no need to beat yourself up over what you didn't do right.
(That'll be $100, but you can pay what you can /j)
There are two main reasons to increase the dose: it isn't working, or it isn't working fast enough.
The first case has an obvious solution: do something else. Personally, Tirz wasn't working very well, so I added Retatrutide. It turns out they complement each other.
The second case is impatience. That comes down to avidity. Always feeling empty. What a coincidence!
If you're eating a lot, it's worth taking a closer look at the wound that's making you feel empty.
There is a trick: the gratitude journal. Write a few lines every evening about what you notice you've received during the day. It works in 2-3 weeks. and it's much cheaper than a session with a therapist. And there's no need to beat yourself up over what you didn't do right.
(That'll be $100, but you can pay what you can /j)
lessthanhalf
GLP-1 Specialist
Assuming the reason is a true stall, occurring more than a year after starting, or low rates of weight loss with a degree of hunger that is difficult to be comfortable with, it is reasonable.
I think it depends a bit on how severe the obesity is in the first place, but most of the time it has to be a pretty major problem if 15mg of tirz was not enough. But in general the obesity needs to have been severe enough to justify unknown extra risks from high dose/combo strategies.
The only higher dose studies so far were for semaglutide at 7.2mg and 16mg, both caused some extra weight loss, but not huge amounts, and had a lot more side effects. But importantly there were no new severe unexpected adverse effects from the higher doses, while this does not prove higher dose tirz is safe it is at least a bit reassuring.
Going from 15mg up to 20mg probably depends on what happened when you increased from 10 to 15mg, if you found those increases helpful, and did not cause major issues with side effects , then increasing the dose might be reasonable.
Otherwise adding in elora or cagri makes sense, but at low doses with slow increases like 0.25 of cagri or 1mg of elora. Cagri is cheaper , elora is super new and less is known but is probably more effective with less side effects , especially at low doses of 3mg or less, but at higher doses above 6mg does also have high rates of nausea and fatigue up to about 50/50%, but a bit better than high dose cagri.
I think it depends a bit on how severe the obesity is in the first place, but most of the time it has to be a pretty major problem if 15mg of tirz was not enough. But in general the obesity needs to have been severe enough to justify unknown extra risks from high dose/combo strategies.
The only higher dose studies so far were for semaglutide at 7.2mg and 16mg, both caused some extra weight loss, but not huge amounts, and had a lot more side effects. But importantly there were no new severe unexpected adverse effects from the higher doses, while this does not prove higher dose tirz is safe it is at least a bit reassuring.
Going from 15mg up to 20mg probably depends on what happened when you increased from 10 to 15mg, if you found those increases helpful, and did not cause major issues with side effects , then increasing the dose might be reasonable.
Otherwise adding in elora or cagri makes sense, but at low doses with slow increases like 0.25 of cagri or 1mg of elora. Cagri is cheaper , elora is super new and less is known but is probably more effective with less side effects , especially at low doses of 3mg or less, but at higher doses above 6mg does also have high rates of nausea and fatigue up to about 50/50%, but a bit better than high dose cagri.
Gr33dyOctopus
GLP-1 Enthusiast
Geez, I took an extra 5mg of reta on top of normal doaage and shit water for two days straight
