To move or NOT to move?

[FLglpguy]

I started Tirz on May 7th 2026 and as of today June 29th (53 days later) I have lost exactly 35lbs!!!! SW: 386lbs CW: 351lbs I'm 6'2" tall -- I am ecstatic to say the least. I have had ZERO food noise, and still don't have any at all. I have followed the normal protocol of: 2.5mg x 4 weeks, 5mg x 4 weeks and this Wednesday, July 1st I am supposed to go to 7.5mg.

My question is should I titrate up based on how well I have responded to the smaller doses? I don't want to move up just for the sake of doing it. My first thoughts are to stay at 5mg unless I start having food noise. Having a higher % of meds in my system doesn't burn more fat or do anything additional for me that I know of.

Please share your thoughts and suggestions.

 

[Flash-BCR]

I think staying at 5mg makes sense....What was your starting weight and what is your goal weight?...

 

[JohannesSweden77]

I started Tirz on May 7th 2026 and as of today June 29th (53 days later) I have lost exactly 35lbs!!!! I am ecstatic to say the least. I have had ZERO food noise, and still don't have any at all. I have followed the normal protocol of: 2.5mg x 4 weeks, 5mg x 4 weeks and this Wednesday, July 1st I am supposed to go to 7.5mg.

My question is should I titrate up based on how well I have responded to the smaller doses? I don't want to move up just for the sake of doing it. My first thoughts are to stay at 5mg unless I start having food noise. Having a higher % of meds in my system doesn't burn more fat or do anything additional for me that I know of.

Please share your thoughts and suggestions.

I've been on Tirz for 7 months now and found that the best is to stay as long as possible on the dose you're on. For me it's 10mg every 5th day so that is also a way to do it instead of every 7 days. So I would stay as long as I could on 5mg and when you start feeling hungry and hearing the food noise then it's time to either go up (it doesn't have to be 7,5mg, could be less) or try like me every 5th day or why not every 6th day? The way to do it are many.

 

[Deonitis]

I only moved up when I lost appetite suppression or the scale stopped moving. More or less listen to your body when it comes to upping your dose. Forget the trials data dosage wise unless you want to spend more money when not needed

 

[Deonitis]

I've been on Tirz for 7 months now and found that the best is to stay as long as possible on the dose you're on. For me it's 10mg every 5th day so that is also a way to do it instead of every 7 days. So I would stay as long as I could on 5mg and when you start feeling hungry and hearing the food noise then it's time to either go up (it doesn't have to be 7,5mg, could be less) or try like me every 5th day or why not every 6th day? The way to do it are many.

Also split dosing is a thing. It helped me not have those 6th day hungers. I did every 3 1/2 days. Slows you down from upping dosage. Everybody is different, that worked for me

 

[JohannesSweden77]

I only moved up when I lost appetite suppression or the scale stopped moving. More or less listen to your body when it comes to upping your dose. Forget the trials data dosage wise unless you want to spend more money when not needed

I was a slave to the once a week and uping the dose 2,5mg like that was the only thing you could do because that was what the doctor said. Now I'm trying the every 5th day and see how that is. Maybe I'll try half a dose every 3rd day. Time will tell. I do know that every 7 days is not for me because I don't want to feel like crap 2 days a week.

 

[FLglpguy]

I'm 6'2" tall - started at 386lbs and I am now at 351lbs --- 53 days total on Tirz.

Goal is 220lbs.

 

[Skidude]

I'm 6'2" tall - started at 386lbs and I am now at 351lbs --- 53 days total on Tirz.

Goal is 220lbs.

Personally I went by the results.
Stay at the dose your at until you need to raise it.

Some have hit goal without ever getting to 10mg

I went 13 weeks before 7.5 and hit goal at 12.5

 

[BrightCandle]

The goal is loosing weight at a reasonable safe rate. I would argue you stick with a dose until it stops working for a month, if you cease loosing weight then up the dose. The least cost and side effects comes from using the minimum dose you can get away with for as long as you can get away with it. The trials showed that the benefit to being on the highest dose the whole time is really minimal compared to switching to the highest dose later on when loss stalls.

 

[CJsMom]

You are having great success at a low dose. Stay there until that changes. If food noise comes back, or you plateau with no change for several weeks, move up. Sadly there may come a day when the maximum dose just maintains your weight and you want to put that day off as long as possible. These drugs seem to give their greatest losses early on and then peter off as your body adjusts. Take advantageofthat by leaving yourself room to move up if that happens.

 

[CranberryRocker]

I’ve been on Tirz for over 8 months and only go up when the food noise comes back and I find myself snacking (even though snacking choices are mainly fruit and raw carrots). I do split dose but when I go up I go up 1mg per week, so 0.5mg increase for each of my 2 doses, typically after 6-8weeks on eat dose. I am hoping that means my maintenance dose can be lower/cheaper (although much less of a concern now with my freezer stocked with gray 😉) I still have about 10-15lbs to go and plenty of runway but also would consider stacking a bit a Reta or cagri if things took a stall at higher doses.

 

[skeptick]

I'm 6'2" tall - started at 386lbs and I am now at 351lbs --- 53 days total on Tirz.

Goal is 220lbs.

You go guy

 

[Frandroid]

A lot of people have already recommended this, but I'd also like to share that in my experience, it's best to stay on a dose if it is still helping. Only go up when the food noise returns, or when you want to break through a plateau of more than 4-8 weeks.