Topical spot-reduction of fat (aminophylline cream)

[Noerofthings]

Here is a 2006 study on topical aminophylline cream used on the waist to spot-reduce fat in...well, the waist: https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/j.1463-1326.2006.00600.x. These are their results:

The reduction in waist circumference was 11 ± 1.0 cm in the aminophylline cream group and 5.0 ± 0.6 cm in the control group (p < 0.001). The reduction in waist circumference was significant for both women and men, but the women lost significantly more waist girth.

I did a cursory search on this forum before posting and only a few people have talked about it before; including milos, who posted this systemic review of aminophylline, which I found very interesting: https://pmc.ncbi.nlm.nih.gov/articles/PMC9978326/. It concludes:

Aminophylline topical formulation offers a safe, effective, and much less invasive alternative to cosmetic surgery for the localized reduction of fat. Conducting further trials to compare the efficacy of different concentration of aminophylline is suggested for future works, as well as evaluating the efficacy of other xanthines in local fat burning.

So, quite promising. I find aminophylline to closely align with my goals since I don't really want to lose weight so much as move the fat around (and obviously, don't want to lose muscle). Aminophylline seems a bit tough to get ahold of, but when/if I do, I'd probably experiment with how it affects fat while eating at maintenance, since most of the studies on aminophylline are on people who are actively losing weight & are women.

 

[Slogger]

Following...this is very interesting.

 

[llmdds]

Oooh I’m so glad you brought this up!! I’ve been researching this as well and would love to find some somewhere to experiment with!!!

 

[vjorvj5150]

Interesting

 

[lessthanhalf]

I would have thought this was technically impossible, but you have evidence of a trial with statistically significant results. I tried to find the study but only got the abstract, but it said there had been other trials saying it worked for thigh fat, and blood levels of the drug were undetectable and no side effects. Did not say how many people in the study. Given how many either snake oil - don't work or invasive - do work, treatments there are for this issue I wonder why it did not take off?

 

[Nopenada]

This would be my dream. On Reta and doing weight training now and just watching my boobs and butt melt away while my waist stays the exact same size.