... kindly link to evidence of this
Who then do you rely on for purity and mass testing before injecting these same chemicals into your system?
Unable to inject meds.
- Thread starter Rohjay
- Start date
raw_oyster_eater
lemon bottle brewer
i would be OK freezing reconstituted material. you just don't want to break glass. i guess i could do an experiment and see if the product is still effective after freezing.
i have some Pt141, oxytocin and tesa i could give a try.
i have some Pt141, oxytocin and tesa i could give a try.
I think the peptide matters. Tirz had almost no loss after four freeze/thaw cycles. Epithalon was also tested and lost 9% after one cycle and 18% after four cycles.
I'm no scientist but these results might be related to the length of the peptide chain with shorter chains being less hearty than longer chains (like Tirz).
raw_oyster_eater
lemon bottle brewer
intuitively, i'd think the longer molecules would be more vulnerable.
triz is a big one 4800g/mole
FAQs | Ozempic® (semaglutide) injection 0.5 mg, 1 mg, or 2 mg
Find answers to frequently asked questions about Ozempic® (semaglutide) injection. Get answers about prescribing Ozempic®, patient resources, and storing the medication. Read Important Safety and Prescribing Information, including Boxed Warning.
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Wait, Do You Actually Need to Refrigerate Ozempic?
Ozempic is an injectable weight loss medication that must be stored properly to ensure safety. New pens must be kept in the fridge until ready for use.
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Thank you. Those are instructions, not scientific evidence of any sort.FAQs | Ozempic® (semaglutide) injection 0.5 mg, 1 mg, or 2 mg
Find answers to frequently asked questions about Ozempic® (semaglutide) injection. Get answers about prescribing Ozempic®, patient resources, and storing the medication. Read Important Safety and Prescribing Information, including Boxed Warning.www.novomedlink.com
And they're for the mechanical injector device (which everyone agrees shouldn't be frozen), but also subsequently incorporated in the Lilly Direct single-dose vials.
raw_oyster_eater
lemon bottle brewer
the pharmacists are pretty committed to keeping it in the fridge.
I’m sure Jano is doing fine financially, but let’s call a spade a spade. He is doing tests for illicit substances and he is not an accomplished scientist who has been peer reviewed or published. If you look into him there are plenty of people discrediting him on MesoRX, Reddit, etc.
Freezing the peptides causes crystallization which can alter them on a molecular level, making them dangerous. Keeping liquid in the fridge is totally different. That’s just a risk of degradation and bacteria growth.
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"Lyophilizer machines, also known as freeze dryers, can reach temperatures as low as -40°C to -80°C (-40°F to -112°F) for freezing the product, and condensers can reach -50°C to -105°C (-60°F to -180°F). "
While I believe the janoshik testing on freezing tirz, this post indicates you should be a bit more careful before you act as an authoritative source.
You'll notice there is a key word in your quote - dryers. Part of the lyophilization process involves creating a vacuum and drying out the vial as part of how it works. This is a key part of the process, otherwise they wouldn't need to use freeze dryers instead of just any other ultra-cold freezing method.
Why is it a key part of the process? Because it is known that "wet" freezing can damage the structure of many molecules - explicitly because of the crystallization AndyPanda is mentioning. While tirz in specific looks to be OK, we know that freezing/thawing HGH, for example, when it has moisture in the vial can and does cause damage, resulting in insoluble aggregates forming. Epitathlon was mentioned up thread. There are many many others as well.
Lyophilization is done under vacuum and it removes ice crystals through sublimation. Manufactures also use cryoprotectants to mitigate damage that are removed through the process. Additionally, during lyophilization the liquid freezes at controlled pace.
Jano conducted the freeze/thaw test in accordance with the directions provided to him by the big group testing server. As I previously stated, this is an N=1 test but I would like to see more tests to confirm these results and would happily contribute to them, but this is the only test that I am aware of for Tirz.
I'm not sure why Lilly says not to freeze Mounjaro/Zepbound pens but I could see the freeze expansion process causing the pen to leak or the stopper to be forced out of the cartridge in these pens.
