Unable to inject meds.

[AndyPanda]

"Lyophilizer machines, also known as freeze dryers, can reach temperatures as low as -40°C to -80°C (-40°F to -112°F) for freezing the product, and condensers can reach -50°C to -105°C (-60°F to -180°F). "

Lyophilization is done under vacuum and it removes ice crystals through sublimation. Manufactures also use cryoprotectants to mitigate damage that are removed through the process. Additionally, during lyophilization the liquid freezes at controlled pace.

 

[GimmeABreak]

I’m sure Jano is doing fine financially, but let’s call a spade a spade. He is doing tests for illicit substances and he is not an accomplished scientist who has been peer reviewed or published. If you look into him there are plenty of people discrediting him on MesoRX, Reddit, etc.

Freezing the peptides causes crystallization which can alter them on a molecular level, making them dangerous. Keeping liquid in the fridge is totally different. That’s just a risk of degradation and bacteria growth.

Jano conducted the freeze/thaw test in accordance with the directions provided to him by the big group testing server. As I previously stated, this is an N=1 test but I would like to see more tests to confirm these results and would happily contribute to them, but this is the only test that I am aware of for Tirz.

I'm not sure why Lilly says not to freeze Mounjaro/Zepbound pens but I could see the freeze expansion process causing the pen to leak or the stopper to be forced out of the cartridge in these pens.

 

[fetefille]

I’m trying to help a friend by introducing him to compound semaglutide. I found him a website with a good price and directed him to Amazon for accessories. He’s about 6 injections in and complaining that he’s unable to depress the plunger to dispense the medicine. I’ve had issues like this when Luer lock needles weren’t screwed on tight enough, but this is a one piece syringe. Any ideas what might be going on?

If he got the syringes from Amazon, that may be the problem. I normally order from a diff site, but was in a hurry. Ordered 2 boxes of my normal brand. First box felt and operated as normal. This second box has a distinctly different feel in my hand and the plunger requires so much more force. I mean, I have to use both hands once it’s filled and inserted to depress it.

So maybe he’s got a counterfeit box like mine. I knew it was a risk, it’s not the end of the world, and I was warned. I just won’t do it again.

 

[keangkong]

When I have too much positive or negative pressure I find injecting a syringe without the needle will balance out. This venting effect allows me to try again by injecting equal air to my next withdraw. So i vent , then an example would be to inject .5 ml for a 50 unit dose. then extract my 50 units.
please let others comment on this, but it seems to work for me.

Do you mean injecting the syringe without the plunger?

 

[raw_oyster_eater]

I'm not sure why Lilly says not to freeze Mounjaro/Zepbound pens but I could see the freeze expansion process causing the pen to leak or the stopper to be forced out of the cartridge in these pens.

isn;t that glass in there?

 

[Skidude]

Do you mean injecting the syringe without the plunger?

That is correct, I also misunderstood the issue and the entire response was flawed.
Funny enough I noticed the second part the next morning, I just now recognize the "without the needle portion" so yes, vent without plunger or use a luer lock needle. my mistake

 

[GimmeABreak]

isn;t that glass in there?

It is, its very similar to the carts we use in our pens but has a needle affixed to it.

 

[Mykrodot]

I’m trying to help a friend by introducing him to compound semaglutide. I found him a website with a good price and directed him to Amazon for accessories. He’s about 6 injections in and complaining that he’s unable to depress the plunger to dispense the medicine. I’ve had issues like this when Luer lock needles weren’t screwed on tight enough, but this is a one piece syringe. Any ideas what might be going on?

As you can tell folks definitely have an opinion on this one. You are going to have to dig deep and decide what you are comfortable with. I would start with a Google search for “storage of reconstituted peptides freeze”, there is a lot of info out there. Best wishes.

 

[noggin]

When I have too much positive or negative pressure I find injecting a syringe without the needle will balance out. This venting effect allows me to try again by injecting equal air to my next withdraw. So i vent , then an example would be to inject .5 ml for a 50 unit dose. then extract my 50 units.
please let others comment on this, but it seems to work for me.

How on earth do you inject a syringe without the needle

 

[keangkong]

How on earth do you inject a syringe without the needle

OP later clarified that to refer to injecting without the plunger. I had correctly guessed that plunger was what was intended, but only did so because I also inject the syringe without the plunger to eliminate any discrepancies in air pressure.

 

[fetefille]

If he got the syringes from Amazon, that may be the problem. I normally order from a diff site, but was in a hurry. Ordered 2 boxes of my normal brand. First box felt and operated as normal. This second box has a distinctly different feel in my hand and the plunger requires so much more force. I mean, I have to use both hands once it’s filled and inserted to depress it.

So maybe he’s got a counterfeit box like mine. I knew it was a risk, it’s not the end of the world, and I was warned. I just won’t do it again.

Little follow up: ordered from my normal place and the difference is NIGHT & DAY. The second box I got from amz was definitely fake. It was made of way cheaper material, the plunger would pop out with minimal pull, the needle wasn't as sharp as it should've been, and even the barrel felt/looked off (made of a frosted plastic).

So yea, if none of that matters and you're a boss at jabbing yourself with dull needles, go on with your bad self. However, if you need that Easy Touch comfort, skip Amazon and go for a diabetic supply place.