Vibegron, β3, and brown fat

[diogenes]

What do people think about β3 agonism -> brown fat activation -> higher RMR as a way to fight obesity?

As I understand, this was tried with mirabegron, but required up to 200mg to get a useful RMR boost, which caused too much norepinephrine interference and β1/β2 spillover (hypertension, tachycardia, etc). But it worked! Patients got a 200kcal/day boost, which is a lot.

I saw this study is being done with vibegron, a (patented) more specific β3 agonist: https://clinicaltrials.gov/study/NCT06987383. I guess the hope is that it could boost RMR without the side effects.

If this is true, it seems like it could be a useful adjunct to GLP-1 drugs. What do people think?

 

[wildcat0367]

What do people think about β3 agonism -> brown fat activation -> higher RMR as a way to fight obesity?

As I understand, this was tried with mirabegron, but required up to 200mg to get a useful RMR boost, which caused too much norepinephrine interference and β1/β2 spillover (hypertension, tachycardia, etc). But it worked! Patients got a 200kcal/day boost, which is a lot.

I saw this study is being done with vibegron, a (patented) more specific β3 agonist: https://clinicaltrials.gov/study/NCT06987383. I guess the hope is that it could boost RMR without the side effects.

If this is true, it seems like it could be a useful adjunct to GLP-1 drugs. What do people think?

A GLP-2 or retatrutide (because there is no such thing as "GLP-3") will work well without risking side effects from other drugs. Add some Mots-C and 5 amino 1mq for even better results. Weight loss is not a race you need to run fast, in fact in most cases fast is bad. lean mass loss and weight regain all happen when you push too hard and do not follow with resistance training and high protein.