Weight Loss Maintenance

[marcusjame]

I am currently on 10MG weekly Tirzepatide and have been consistently losing weight. In about 3 month I expect to be at my target weight and then need to maintain the target weight. I have been reading up about CagriSema as a possible long term weight maintenance strategy. I searched this forum and don't see anything specific to CagriSema as a weight maintenance strategy. In other online sources I have seen suggestions of a 1 mg Cagri 1 mg Sema dose for a long term maintenance strategy. The half lives of the two drugs are a bit different but does anyone have experience with this?
I have seen CagriSema mix being sold. It would be easier to dose out of 1 vial but using a vial of Cagrilintide and a separate vial of Semaglutide would allow more controlled dosing.
Does anyone have experience with this?

 

[Sheshe91]

I want to know this as well as I want to buy the mixture but I’ve been told that they have different PH? Confused.com

 

[Calm Logic]

Reconstituting agent for Cagrilintide

Sep 9, 2024

I'm looking for something other that bactrostatic water for Cagrilintide. The agent needs to have a ph of 4. Any suggestions?

• Christine S
• Replies: 94
• Forum: Cagrilintide

 

[chmuse]

I am currently on 10MG weekly Tirzepatide and have been consistently losing weight. In about 3 month I expect to be at my target weight and then need to maintain the target weight. I have been reading up about CagriSema as a possible long term weight maintenance strategy. I searched this forum and don't see anything specific to CagriSema as a weight maintenance strategy. In other online sources I have seen suggestions of a 1 mg Cagri 1 mg Sema dose for a long term maintenance strategy. The half lives of the two drugs are a bit different but does anyone have experience with this?
I have seen CagriSema mix being sold. It would be easier to dose out of 1 vial but using a vial of Cagrilintide and a separate vial of Semaglutide would allow more controlled dosing.
Does anyone have experience with this?

Cagri isn't technically approved yet, even non grey. I would personally stick with lowering the dose of tirz, spreading it to longer time between doses, or switch to low dose sema.

 

[Calm Logic]

And the accounts of cagri fatigue are a big turn off to me. Makes tirz-related fatigue sound like nothing.

 

[CallieKat]

Why not stay on tirz? Back in the day it was really expensive. Not so much anymore.

 

[Jacquiew24]

I am also within 10 lbs of my goal I am taking tirzepatide what is a maintenance dose?

 

[chmuse]

I am also within 10 lbs of my goal I am taking tirzepatide what is a maintenance dose?

The dose at which you stop losing weight and also don't gain. (I'm not being snarky I promise!) You'll have to play with it. Lower your dose, increase days between doses. See what works for you.

 

[wwwAngels]

The dose at which you stop losing weight and also don't gain. (I'm not being snarky I promise!) You'll have to play with it. Lower your dose, increase days between doses. See what works for you.

Yeah, that sounds about right. I ended up not losing for a month on 1.5mg of Sema, so I know I'll probably have to stick to at least 1mg for maintenance. I just started now stacking Tirz and Sema to lose those last 4 pounds.

 

[marcusjame]

Why not stay on tirz? Back in the day it was really expensive. Not so much anymo

I was thinking of switching because of Magpie syndrom, being attracted to something shiny new and different. After a few days and reflection, I will probably stay on a lower doese of tirzepatide.

 

[Calm Logic]

Maybe you could get your reta fix by reselling it, hahaha. MagpiePeptides.com

But to differentiate yourself for the DEA, also resell beta-blockers:

Post in thread 'Heart racing from Reta'

May 15, 2025

I am ordering low-dose nebivolol from India just in case (5 mg tablets, which can be split in half). I read about it at the Meso forum for fellow users of the stimulant clenbuterol. Nebivolol could help I assume with elevated heart rate from reta, for when I try reta:

A review of the safety and efficacy of nebivolol in the mildly hypertensive patient - PMC

Nebivolol is a third generation beta-blocker, which can be distinguished from other beta-blockers by its hemodynamic profile. It combines beta-adrenergic blocking activity with a vasodilating effect mediated by the endothelial L-arginine nitric ...

pmc.ncbi.nlm.nih.gov

Although nebivolol (5 mg) and the calcium antagonist nifedipine (20 mg) were equally effective in lowering blood pressure, nebivolol also significantly reduced heart rate (Van Nueten et al 1998a) and adverse events associated with nifedipine treatment caused...

• Calm Logic

• 

 

[marcusjame]

As I mentioned I was thinking of switching to another pepetide more out of the novelty of wanting something new and shiny - the magpie effect.
If I was to start a research peptide company MagpiePeptides would be a good name. Some of them seem to come and go so the theme could be bird names or bird themes. Magpie, Pica, Robin, Crow, Nest, Feather...hmmm.. I am guessing I don't have a future in naming or running peptide companies. Oh well.
I will stick to the tirzepatide.