What a difference two years makes….. Meniscus/Osteoarthritis

jw717us

GLP-1 Apprentice
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Dec 16, 2025
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I’ve shared my Selank impact in another post and wanted to share the other part of my knew found appreciation for peptides.

Years ago I took martial arts with my young child rather than sit for hours every week doing nothing. We made blackbelt (strip-mall TKD style 😉 but then had some military guys join as the school started teaching BJJ. The classes became a little more cut-throat and in my 40s I was less than happy with some 26 years old infantry guys deciding to go for the knees and easy drops. My knees didn’t appreciate it and neither did I.

It eventually led to meniscus surgery to repair the damage. I trusted the surgeon and he worked wonders on a shredded rotator cuff years before. This time he didn’t warn me that osteoarthritis was a likely outcome and great accelerated. Years later that knee has started to sound like a bowl of rice krispees when I climb stairs. I’ve seen 2 more doctors and all of them question why that surgery was proposed. They also had no other path forward other than injections for a couple years followed by a knee replacement that will last approx 10 years. I only get two of those. I needed to stretch that roadmap out…

After Tirz for weightloss opened my eyes to peptides I started researching support for it. I paid through the nose and got telehealth subscription Rx’s for NAD+ and Semorelin. Those both made a huge difference in my GLP kickstarted weight loss journey to those of my wife and two other friends who started at the same time. The three of them are all down 20%ish in weight but have loss fat/muscle evently. Between those two peptides and working out I’ve managed to lose fat while gaining an equal % of muscle. Effectively down 45 pounds but muscle mass maintained.

Looking into the knee came next…. I started with BPC/TB and then, after more learning, shifted to KLOW. I researched other adjacent supplements and add collagen, glucosamine/chondroitin, and a couple others. I’ve been at it 3 months with leg training and biking.

The results? Two years ago when we were at a ski resort in Canada I could barely make it down a 5 mile green run due to knee and leg pain. I was slowing up my wife, daughter, and FIL. I had to go in early every single day. It was embarrassing.

Flash forward to today and it’s like I pulled 15 years off of my shoulders. I am skiing 5-6 hours every day. Unless I hit something VERY wrong I feel nothing. I’m outskiing my teenager and family like never before. I’ve upped KLOW to morning and evening every day for recovery and I’m waking up with legs feeling good and ready to go.

Just sharing this in case anyone else is wondering if this can make a difference. I still have 3 more days of skiing so we’ll see what happens!

For the future I’m also considering AOD9604 and Cartalax but not ready to commit year. I need to do a lot more reading on both.
 
I’ve shared my Selank impact in another post and wanted to share the other part of my knew found appreciation for peptides.

Years ago I took martial arts with my young child rather than sit for hours every week doing nothing. We made blackbelt (strip-mall TKD style 😉 but then had some military guys join as the school started teaching BJJ. The classes became a little more cut-throat and in my 40s I was less than happy with some 26 years old infantry guys deciding to go for the knees and easy drops. My knees didn’t appreciate it and neither did I.

It eventually led to meniscus surgery to repair the damage. I trusted the surgeon and he worked wonders on a shredded rotator cuff years before. This time he didn’t warn me that osteoarthritis was a likely outcome and great accelerated. Years later that knee has started to sound like a bowl of rice krispees when I climb stairs. I’ve seen 2 more doctors and all of them question why that surgery was proposed. They also had no other path forward other than injections for a couple years followed by a knee replacement that will last approx 10 years. I only get two of those. I needed to stretch that roadmap out…

After Tirz for weightloss opened my eyes to peptides I started researching support for it. I paid through the nose and got telehealth subscription Rx’s for NAD+ and Semorelin. Those both made a huge difference in my GLP kickstarted weight loss journey to those of my wife and two other friends who started at the same time. The three of them are all down 20%ish in weight but have loss fat/muscle evently. Between those two peptides and working out I’ve managed to lose fat while gaining an equal % of muscle. Effectively down 45 pounds but muscle mass maintained.

Looking into the knee came next…. I started with BPC/TB and then, after more learning, shifted to KLOW. I researched other adjacent supplements and add collagen, glucosamine/chondroitin, and a couple others. I’ve been at it 3 months with leg training and biking.

The results? Two years ago when we were at a ski resort in Canada I could barely make it down a 5 mile green run due to knee and leg pain. I was slowing up my wife, daughter, and FIL. I had to go in early every single day. It was embarrassing.

Flash forward to today and it’s like I pulled 15 years off of my shoulders. I am skiing 5-6 hours every day. Unless I hit something VERY wrong I feel nothing. I’m outskiing my teenager and family like never before. I’ve upped KLOW to morning and evening every day for recovery and I’m waking up with legs feeling good and ready to go.

Just sharing this in case anyone else is wondering if this can make a difference. I still have 3 more days of skiing so we’ll see what happens!

For the future I’m also considering AOD9604 and Cartalax but not ready to commit year. I need to do a lot more reading on both.
Next to the GLP-1's, (PPS) Pentosan Polysulfate Sodium has been the biggest change for me pain wise. It's not a peptide, but has been refurbished from an old bladder medication and it works great on Arthritis. I get it through my Longevity Dr. and the compounded pharmacy he works with. It is a bit of a blood thinner, runs about $250 for a 6 week course and you inject 2X a week. It lasts about a year for most people, I've run 2 courses now, both times after 3 weeks the pain starts back. I can't take regular Arthritis drugs, which is why I looked into this. Think of it, like Cartalax on steroids. It's currently in stage 3 trials in the US & Australia, to bring it too market in the next year or two. They've given it to horses and dogs for a while now and my dog is on it.

I've had both my knees replaced and I'm not much older than you, keeping the weight off was crucial for the replacement - replacement knee 15-20 years down the road. You mentioned a knee replacement only lasting 10 years?
 
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