What helps fatigue from Tirz?

RosebudFox

RosebudFox

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I have been on tirz for about six months. The first few months were great, very few side effects. My doses have been most typically 2.5mg per week and sometimes a little less than that or a couple of weeks off for work or travel.
About three or four months in, I started getting some pretty crippling (for me) fatigue. It seems strange to have that late of onset. Maybe it is normal?
I have tried bi-weekly B12 shots. My hydration could be a little better, but I do have electrolytes every morning. I think I am eating enough and prioritizing protein.
I tried reta (2mg weekly for a month) a couple of months in, but I backed off because the elevated heart rate felt like anxiety to me.
I think I prefer tirz, but neither compound seems to be my goldilocks. Should I stack? It kind of scares me.
 
staffn1 said:
How strenuous are you exercising and strength training? I always found exercise to boost my energy.
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I am a consistent exerciser. Strength training and moderate exercise does give me a little boost. I was not able to train as I'd like to during the fatigue times (a mt bike ride or a hot yoga class would drain me).
 
Without knowing how much weight you have lost it is hard to say if that might be the cause or a cause of fatigue. Also depending on age and sex maybe worth getting iron levels checked, normally blood sugars as well but you would be less likely to develop diabetes while losing weight on tirzepatide. Depending on how good your diet is a multivitamin is worth considering.
 
Thank you for the tips! I had to drink a Celsius today to get a lot done and hit afternoon workout haha. Vitamins are definitely a healthier route.
 
lessthanhalf said:
Without knowing how much weight you have lost it is hard to say if that might be the cause or a cause of fatigue. Also depending on age and sex maybe worth getting iron levels checked, normally blood sugars as well but you would be less likely to develop diabetes while losing weight on tirzepatide. Depending on how good your diet is a multivitamin is worth considering.
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Thank you! This is helpful. I didn't have a ton of weight loss. It was some impossible hormonal weight gain (F, 46). My iron used to be much lower, but I supplement it now, and it's normal. I'll look into a good multi. Diet- I have actually leaned more into protein and fats lately because no food sounded good for a while. I am working on cleaning it up now, and hopefully that will help.
 
Maybe invest in a CGM for 30 days? Hypoglycemia can be a very real issue with GLP’s, although at that very small dose you would have to be a super super responder.
 
latviantower said:
Maybe invest in a CGM for 30 days? Hypoglycemia can be a very real issue with GLP’s, although at that very small dose you would have to be a super super responder.
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Good advice on the CGM! Thank you. This is something that I had considered anyway.
 
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Calm Logic said:
Hypoglycemia is not common at all with non-diabetic use of GLPs.

Instead, there can be symptoms of pseudohypoglycemia due to the body adjusting, such as from orthostatic hypotension:


A CGM seems cool to use, though a $10 glucose meter kit from Walmart may be sufficient for piece of mind.
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They are super cool. My wife was trying to find her sweet spot in and out of ketosis, timing the adding of exogenous ketone ester shooters, micromanaging her few carbs - glucose and blood ketone testing up to six times a day was a pain - the CGM app allowed her to map out her blood sugar daily peaks and troughs, note meals and snacks, and pinpoint ketone timing. Nerds at play!
 
The exhaustion has been one of the trickier things to manage in the first 6 months. I have gotten into a routine to treat Day 6,7 as a max hydration and feeding day in anticipation of shot day on Day 7. Almost like I am prepping to play in a football game on shot day. That and 3 other Peps seem to push me thru.
 
chewonmysac said:
The exhaustion has been one of the trickier things to manage in the first 6 months. I have gotten into a routine to treat Day 6,7 as a max hydration and feeding day in anticipation of shot day on Day 7. Almost like I am prepping to play in a football game on shot day. That and 3 other Peps seem to push me thru.
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Good advice! I'll be more proactive this week to see if it helps.
 
chewonmysac said:
The exhaustion has been one of the trickier things to manage in the first 6 months. I have gotten into a routine to treat Day 6,7 as a max hydration and feeding day in anticipation of shot day on Day 7. Almost like I am prepping to play in a football game on shot day. That and 3 other Peps seem to push me thru.
Click to expand...
What other peps?
 
Sugar, a boatload of sugar. 1st thing in morning, I drink a cup of juice with an added packet of sugar on pin day and 1 day after. This was recommended to me by my PCP, and worked like a charm since Month 1. Stuff like Gatorade only helps if it's the regular full sugar stuff.

I do not recommend adding more peps since you know you're getting the fatigue directly from the Tz, it is most likely from low blood sugar. Ppl seem to forget these are diabetic meds...it's meant to dramatically lower your blood sugar. You can get a monitor to check, I was never bothered to get one.

Don't forget a simple solution to fatigue is eating more aka your body needs fuel (carbs preferred) to feel energized. Try to increase your carbs the day you take Tz, and monitor if you see a difference. On pin day it's sometimes hard to get a full meal in high in carbs, so that's why my PCP told me liquids is the way to go...soda even works (caffeine + sugar combo is great). Protein IMO is overhyped and does NOT fix fatigue, it's a way to maintain muscle and I think that's something to worry about post-WL tbh.
 
Honestly, upping my water intake seriously the day prior to my dose, and keeping on top of it the day of and after helped tremendously.

I had to move my dose day around because I realized I drink way more water at work vs at home or out & about and I would use taking it on Friday or Saturday as an excuse to be lazy and do nothing the day after lol.
 
TazaTaza said:
Sugar, a boatload of sugar. 1st thing in morning, I drink a cup of juice with an added packet of sugar on pin day and 1 day after. This was recommended to me by my PCP, and worked like a charm since Month 1. Stuff like Gatorade only helps if it's the regular full sugar stuff.

I do not recommend adding more peps since you know you're getting the fatigue directly from the Tz, it is most likely from low blood sugar. Ppl seem to forget these are diabetic meds...it's meant to dramatically lower your blood sugar. You can get a monitor to check, I was never bothered to get one.

Don't forget a simple solution to fatigue is eating more aka your body needs fuel (carbs preferred) to feel energized. Try to increase your carbs the day you take Tz, and monitor if you see a difference. On pin day it's sometimes hard to get a full meal in high in carbs, so that's why my PCP told me liquids is the way to go...soda even works (caffeine + sugar combo is great). Protein IMO is overhyped and does NOT fix fatigue, it's a way to maintain muscle and I think that's something to worry about post-WL tbh.
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Thank you! Thank you for helping me to validate the lavendar matcha lattes from Starbucks, that are full of sugar, that I had post pin day! hahah.
All good notes and tips.
I recently listed to a Rich Roll podcast with Simon Hill, and he is on the other side of the protein hype. He quotes several studies that suggest that normal amounts are adequate as long as there is resistance training and higher protein without resistance training does not protect or build muscle.
 
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