Which drug has the best side effect profile?

[tcpnomad]

What is your sense of the side effect profile for all the different drugs on the market these days?

Semaglutide, Tirzepatide, Retatrutide, Eloralintide, Cagrilintide (and other more exotic ones).

What is your thought process in deciding between all of these? Side effects vs efficacy?

 

[Aladran]

I think you don’t really know until you try them. Nausea is a side effect of all of them, but I’ve read anecdotal reports that some will be nauseous on sema but not on tirz and vice versa

 

[bada bing]

If you want best chance of manageable sides, then your dosing ramp up is at least as important as the compound. If I was choosing a best bet for effectiveness verses sides, I'd try Tirzepatide first. But that's only a bet, not a certainty for any one individual.

Some of the subscription based compounding outlets have pretty conservative standard protocols for getting people onto Tirzepatide: Start at 1mg/week for first two weeks then make a decision to go to 2mg if well tolerated. Evaluate for increases every 4 weeks afterwards. Patience has the best chance of avoiding unpleasant sides.

You're going to feel a little different at an effective dose of any of the GLPs. It's not ever going to be just transparent weight loss.

That's not a recommendation, just an observation.