Which Epitalon Dosing??

s2HappyCamper

s2HappyCamper

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While researching one finds there is a wide margin for Epitalon SQ dosages. It ranges from 100-500 mcg daily in some studies for 10-20 days up to 5-10 mg daily for 10-20 days in the traditional western dose. What dose did your RS use? What were the results and any side affects.

There is also a protocols where Epitalon used for 100-500 mcg daily for 10 days on 20 off, repeated monthly. Do you have RS that did this?

Did your research use intranasal dosing?

Pros and cons to the different Epitalon dosing options?
 
s2HappyCamper said:
While researching one finds there is a wide margin for Epitalon SQ dosages. It ranges from 100-500 mcg daily in some studies for 10-20 days up to 5-10 mg daily for 10-20 days in the traditional western dose. What dose did your RS use? What were the results and any side affects.

There is also a protocols where Epitalon used for 100-500 mcg daily for 10 days on 20 off, repeated monthly. Do you have RS that did this?

Did your research use intranasal dosing?

Pros and cons to the different Epitalon dosing options?
Click to expand...
I started with one of the higher-dose protocols and felt pretty terrible honestly, 🙁 headaches, run down, just off. Then I read about lower-dose protocols and decided to try ~1mg/day instead. Huge difference for me.

I also switched to intranasal and that was the game changer. Sleep improved dramatically and now I’m consistently getting 2–3 hours of deep sleep a night.


For me, lower dose + intranasal has been way more tolerable with great results
 
All the protocols I have seen are the 5-10 mgs daily for 10-20 days, but only run it two to three times per year. This is for repair and reset. The smaller doses are more for if you want to run it for longer cycles or continuously. I am ordering some with my next order and planning to run 5mgs daily for 20 days for myself and my wife.
 
This one’s been beaten up quite a bit lately. If you’ll search for “Epitalon,” you’ll find at least 2 recent and very informative threads. Within those threads are links to additional earlier threads where quite a few people outlined their protocol, their reasoning for selecting that protocol, and their observations from those dosages and different delivery messages. There’s a wealth of documented experiences on the forum already that I think you’ll find very useful and then you can make your own determination about which protocol you want to try.
 
s2HappyCamper said:
While researching one finds there is a wide margin for Epitalon SQ dosages. It ranges from 100-500 mcg daily in some studies for 10-20 days up to 5-10 mg daily for 10-20 days in the traditional western dose. What dose did your RS use? What were the results and any side affects.

There is also a protocols where Epitalon used for 100-500 mcg daily for 10 days on 20 off, repeated monthly. Do you have RS that did this?

Did your research use intranasal dosing?

Pros and cons to the different Epitalon dosing options?
Click to expand...
Starting point

https://pep-pedia.org/peptides/epitalon
 
Dos-Dox said:
This one’s been beaten up quite a bit lately. If you’ll search for “Epitalon,” you’ll find at least 2 recent and very informative threads. Within those threads are links to additional earlier threads where quite a few people outlined their protocol, their reasoning for selecting that protocol, and their observations from those dosages and different delivery messages. There’s a wealth of documented experiences on the forum already that I think you’ll find very useful and then you can make your own determination about which protocol you want to try.
Click to expand...
Is this the one that some of that research and dosage is actually for Epithalamin and people get confused? I used epitalon once a long time ago and recall that issue might have been the reason for vastly different dosage discussions.
 
FartfulCodger said:
Are you doing 10mg in 10mL saline? How many sprays per nostril?
Click to expand...
It's going to depend on the dosing the spray bottle gives. I used Snoot bottles which are 0.1 mL of liquid per pump
Take a look at the slick below...
You can mix it this way and if your bottle is giving the same dose per spray, 1 spray is 1mg and 2 sprays is mg. You can play between the two and also between 10-20 days.
 

Attachments

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I'm on 5mg/day for 20 days, 5 days in. I pinned in the evening first two days and struggled with my sleep - changed to morning pins and am sleeping well. Not longer, but deeper and better. As for why I'm not in the mcg range, well, the dosing is still up for debate and I'm still alive and kicking on 5mg/day.
 
I tried a cycle of 10mg per day for 10 days. It was a lot to push in every evening. Had to go really slow so to prevent lumps. Did not have any side effects. Really couldn't tell you if anything happened at all. Going to order the 50mg kit and do it again in 6 months. We will see what happens then.
 
Jfrick11 said:
I started with one of the higher-dose protocols and felt pretty terrible honestly, 🙁 headaches, run down, just off. Then I read about lower-dose protocols and decided to try ~1mg/day instead. Huge difference for me.

I also switched to intranasal and that was the game changer. Sleep improved dramatically and now I’m consistently getting 2–3 hours of deep sleep a night.


For me, lower dose + intranasal has been way more tolerable with great results
Click to expand...
Interesting. I tried 1mg intranasal and felt like 💩. Stiff neck, headache, and a leg pain like sciatica. I went down to 200mcg and still fell awful so I stopped. I want to figure out if maybe subQ would work but I'm scared to try again...
 
In Reddit there is a protocol by a Doctordup2. She is well known for developing protocols with different meds. I think the Epitalon protocol is under r/peptidesource. Look for doctordup2.
 
birdwhacker said:
What time do you dose the epithalon? Does it help you when you're off cycle or only when you're on?
Click to expand...
My RS will do Epitalon and Pinealon for 20 days after the mitochondrial reset protocol of SS-31, NAD+ (my RS is taking oral precursors instead of subq NAD) and MOTS-c cycle. These are stacked on Reta and as needed Cagri. For context, RS is 60 yr woman researching weight loss, improved mitochondrial function, cellular energy and anti-aging/longevity.
 
I am on my first cycle of Epitalon doing 200mcg a day in the mornings. My sleep quality has greatly improved. I feel rested and ready to face the day when I wake up. Next cycle in 4 months I am going to up to 500mcg.
 
birdwhacker said:
What made you decide on morning rather than night?
Click to expand...
Honestly, I have been considering switching to nights. I so it in the mornings because that is what is recommended on Pep Pedia, but I get kinda tired for a bit after I pin it. So I have been considering switching to pinning at night. But I also see a number of people here and elsewhere say that when they pinned it at night, it was worse sleep than if they pinned in the morning. So who knows.
 
KevinS said:
Did I notice anything from that cycle? Not really other than trying to push 1ml a day at one time in one pin.
Click to expand...
That is to be expected.

If you read the studies ( e.g. Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties and Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity ) then it should be obvious that most of the effects would not be immediately noticeable.

The main exception might be increased melatonin synthesis, which could lead to better sleep quality and a more regulated circadian rhythm. However, if your sleep hygiene is already excellent, you likely won't notice a significant change.
Conversely, if your rhythm is heavily disrupted by factors like late-night caffeine or excessive screen time, the benefits might also be masked or minimized.
 
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