Which is the best GLP-1 for reducing systemic inflammation?

[Bioexplorer]

There seems to be a consensus here that tirzepitide is best for reducing inflammation with lots of anecdotal reports that this particular dual agonist provides better pain relief for various ailments than semaglutide or retatrutide. And several members have reported that they switched from Reta to Tirz specifically for this effect.

But it is generally accepted that hs-CRP is the best indicator of systemic inflammation so we have a non-subjective way to measure inflammation reduction already. 10mg Tirz gave a 34% reduction. EL reports substantial reduction in the Reta trials but I haven't seen any numbers. However, based on liver and kidney effects, many people expect a greater reduction in hs-CRP than Tirz.

Did I miss some data showing actual CRP numbers for Reta? Any insight on why Tirz could provide a better subjective effect on inflammation even though Reta probably has similar hs-CRP benefits?

 

[gusterbuster]

Did I miss some data showing actual CRP numbers for Reta? Any insight on why Tirz could provide a better subjective effect on inflammation even though Reta probably has similar hs-CRP benefits?

I just looked and in the phase 2 and 3 trials there were mentions of significant changes vs placebo for hs-crp, but no data provided.

Also supposedly reta has higher GIP activation so its not GIP for inflammation. Tirz has lower GLP1 than Sema, so not the reason. I think this falls under we know it lowers inflammation, but not why. And there are a shocking amount of meds, and medical stuff that we accept it does x without not knowing why.

And hs-CRP has its limitations. Not be all end all. There is a bunch of stuff with cytokines and hs-crp doesn't pick up tissue localized inflammation. Any further is way beyond the scope of a health focused normie.