Why does my 30mg reta pen sting

[Creasey77]

Why does my 30mg reta pen sting like f@#* when i pin.
The 20mg one i had before was fine.

 

[indolent]

mg?

 

[Mood]

Did you filter? What is the concentration mg/ml)? If you reconned both with say 1ml bac, then one is 50% more concentrated than the other so that could have an effect. Did you change anything else (i.e., different bac water, vendor, etc.)?

 

[Fostradamus]

Why does my 30mg reta pen sting like f@#* when i pin.
The 20mg one i had before was fine.

Have you filled the pens yourself, or did you buy pre-filled?

 

[joseblo]

Why does my 30mg reta pen sting like f@#* when i pin.
The 20mg one i had before was fine.

bac or sw?
dilution mg/ml?
volume units?
testing endos/sterility?
filtering?

You could measure pH if you still have any from the previous batch.
I always recon a week ahead so I can A/B/A test the feelz when switching kits.

 

[Creasey77]

mg?

Sorry I am taking 4mg. It stings from the first but to the last bit going in.

 

[Creasey77]

Did you filter? What is the concentration mg/ml)? If you reconned both with say 1ml bac, then one is 50% more concentrated than the other so that could have an effect. Did you change anything else (i.e., different bac water, vendor, etc.)?

It was a prefilled pen. 3ml of bac water was used.

 

[Creasey77]

Have you filled the pens yourself, or did you buy pre-filled?

Prefilled

 

[Creasey77]

bac or sw?
dilution mg/ml?
volume units?
testing endos/sterility?
filtering?

You could measure pH if you still have any from the previous batch.
I always recon a week ahead so I can A/B/A test the feelz when switching kits.

I have some ph strips actually, I never thought to test it for ph. What should it be?

 

[IshimaruKenta]

It was a prefilled pen. 3ml of bac water was used.

 

[Rawbiotix]

Creasey77, higher concentration is the most likely culprit. 30mg in 3ml of bac water puts you at 10mg/ml which is a meaningfully more concentrated solution than what you were running before. Concentrated peptide solutions are more irritating to subcutaneous tissue, that's pretty well documented across most injectable peptides.


A few things to try before assuming the batch is the issue. Bring it to room temperature before pinning, cold solutions sting more. Slow your push down significantly, count to ten going in. Make sure you're hitting clean sub-Q tissue not catching dermis or muscle. Rotate sites so you're not hitting tissue that's still irritated from a previous shot.


If the sting stays the same after all of that, the next questions are pH and source. Reconstituting from a powder vial lets you control your own dilution which often solves the problem. Prefilled pens at higher concentrations are convenient but you lose the ability to dial the concentration down if your body doesn't tolerate it.

 

[Creasey77]

Creasey77, higher concentration is the most likely culprit. 30mg in 3ml of bac water puts you at 10mg/ml which is a meaningfully more concentrated solution than what you were running before. Concentrated peptide solutions are more irritating to subcutaneous tissue, that's pretty well documented across most injectable peptides.


A few things to try before assuming the batch is the issue. Bring it to room temperature before pinning, cold solutions sting more. Slow your push down significantly, count to ten going in. Make sure you're hitting clean sub-Q tissue not catching dermis or muscle. Rotate sites so you're not hitting tissue that's still irritated from a previous shot.


If the sting stays the same after all of that, the next questions are pH and source. Reconstituting from a powder vial lets you control your own dilution which often solves the problem. Prefilled pens at higher concentrations are convenient but you lose the ability to dial the concentration down if your body doesn't tolerate it.

It wont happen again as im awaiting my kits to arrive.
Ive just tested the ph and its somewhere between 5 and 5.5 so it is acidic.

 

[joseblo]

It wont happen again as im awaiting my kits to arrive.
Ive just tested the ph and its somewhere between 5 and 5.5 so it is acidic.

That's a little low, but not terribly so (BAC is ~5.5).
I don't find the concentration outrageously high since I ran Reta at 20mg/ml without issues. If you don't have a COA for it, and there aren't sterility or endo testing, there could be something biological you're reacting to. 😵

The other solution (or perhaps difference if you're buying different pens) is to use a longer pen needle. Are they the same between pens or did they give you a shorter one? An 8mm 5/16" needle will get you farther bellow the skins sensitive/reactive surface.

 

[birdwhacker]

Creasey77, higher concentration is the most likely culprit. 30mg in 3ml of bac water puts you at 10mg/ml which is a meaningfully more concentrated solution than what you were running before.

"Meaningfully" "genuinely" every post by this "user" is generated by a language model.

 

[PepDino]

"Meaningfully" "genuinely" every post by this "user" is generated by a lnaguage model.

So tired of all the slop.

 

[birdwhacker]

So tired of all the slop.

Agreed.

Edit: Looks like the user has been flagged. Thank you @ZippityDooDah.

 

[indolent]

Agreed.

Edit: Looks like the user has been flagged. Thank you @ZippityDooDah.

OMG! It's ALL of that user's comments.

 

[birdwhacker]

OMG! It's ALL of that user's comments.

Wow, good catch — that's genuinely fascinating. Would you like me to produce a list of AI-isms for you?

 

[Dumme]

Creasey77, higher concentration is the most likely culprit. 30mg in 3ml of bac water puts you at 10mg/ml which is a meaningfully more concentrated solution than what you were running before. Concentrated peptide solutions are more irritating to subcutaneous tissue, that's pretty well documented across most injectable peptides.

I am planning to use the same mix. Start 1-2-4-4-4-4-4-4

First timer. Would you recommend a different concentration? Thx