Just curious if anyone else has had their blood pressure/hyper tension issues stay the same, despite losing lots of weight on Sema/Tirz/Reta. I have been on 20mg lisinopril and 10mg amlodipine, recently my PCP switched out the lisinopril for Lisinopril/HCTZ. Most of my other numbers look great, including my A1c which was 4.5 when we checked in August, but my last two blood pressure readings were 154/90 and 139/76 and these are pretty typical for when I go in for various doctor visits. PCP thinks its too much sodium in my food and I suspect he's right. I'm working on cutting out more sodium, but was just curious if this happened to anyone else and if you had any suggestions whether it be diet based or supplement/peptide based.
Blood Pressure/Hypertension not dropping
- Thread starter druell235
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Such1943
GLP-1 Apprentice
Naturally high BP. Made this switch a few months ago with good results:
Pre-switch from Losartan: 137/87
Post-switch to Telmisartan: 116/79
Stack:
Amlodipine 10 mg
HCTZ 25 mg
Telmisartan 40 mg
Another change I was going to make was switching out HCTZ 25 mg for Chlorthalidone 12.5–25 mg, but my doc wanted to monitor the change for a few months.
Pre-switch from Losartan: 137/87
Post-switch to Telmisartan: 116/79
Stack:
Amlodipine 10 mg
HCTZ 25 mg
Telmisartan 40 mg
Another change I was going to make was switching out HCTZ 25 mg for Chlorthalidone 12.5–25 mg, but my doc wanted to monitor the change for a few months.
Foggy-Hollow
GLP-1 Enthusiast
Couple of thoughts -IANAD, just a client. I have an aortic aneurism so have entered this area earlier than some people.
With high blood pressure can come some stiffening of the blood vessels. If thats the case then I believe that part can’t be reversed. Stiffening is why BP must be treated; it spirals up on itself unfortunately.
There are a number of different meds, classified based on how they work. I think my doc said nine different classes but I can’t get google to give me a clear answer. Doc’s point was—if one doesn’t work or has sides that are negative, there’s more to try. The choice can be feathered to benefit, one example is beta blockers can ease anxiety.
Sodium is a u shaped response curve, too little is not good but too much gets all the press. When I tracked I was either eating clean (<500mg) or dirty >2500mg. My parents were low sodium when I was a teen so I just don’t salt things. 🤷♀️ Or I’m eating processed food with too much. Less than 500mg is also not good, electrolytes are related to the electrical impulses your body runs on. I get palpitations if I go several days like this. Track, even if just a few days to see where you are.
Third thought: Reta raises heart rate, I wouldn’t be surprise if it impacted blood pressure. If you haven’t started it yet I’d suggest to run with one of the main 2 first. Tirz has an anti-inflammatory reputation which I think would be beneficial.
It’s a game of inches since it’s the long game on this. Even if you’re over 2k on salt, if you’re under 3 take the win.
Supplement wise I’ve heard good anecdotes about beets and hibiscus tea.
Regular exercise can be regular walks. Walking is very underrated in the US.
With high blood pressure can come some stiffening of the blood vessels. If thats the case then I believe that part can’t be reversed. Stiffening is why BP must be treated; it spirals up on itself unfortunately.
There are a number of different meds, classified based on how they work. I think my doc said nine different classes but I can’t get google to give me a clear answer. Doc’s point was—if one doesn’t work or has sides that are negative, there’s more to try. The choice can be feathered to benefit, one example is beta blockers can ease anxiety.
Sodium is a u shaped response curve, too little is not good but too much gets all the press. When I tracked I was either eating clean (<500mg) or dirty >2500mg. My parents were low sodium when I was a teen so I just don’t salt things. 🤷♀️ Or I’m eating processed food with too much. Less than 500mg is also not good, electrolytes are related to the electrical impulses your body runs on. I get palpitations if I go several days like this. Track, even if just a few days to see where you are.
Third thought: Reta raises heart rate, I wouldn’t be surprise if it impacted blood pressure. If you haven’t started it yet I’d suggest to run with one of the main 2 first. Tirz has an anti-inflammatory reputation which I think would be beneficial.
It’s a game of inches since it’s the long game on this. Even if you’re over 2k on salt, if you’re under 3 take the win.
Supplement wise I’ve heard good anecdotes about beets and hibiscus tea.
Regular exercise can be regular walks. Walking is very underrated in the US.
I was stacking reta with tirz for awhile, not for the blood pressure, just to see how it went and I did not notice any difference versus high dose tirz i.e 13mg tirz vs 7.5 tirz+5reta, but I am willing to try again. I only reached the final combo for two or so weeks, will try it for longer next time.
I will confess to lots of processed/prepared foods on my end, I recently turned on the sodium tracking feature in loseit and it is not pretty.
I have been walking an hour a day since August. I started at three days a week, and now I am up to six days a week, also started some resistance/strength training in October with one of those arm trainer things.
Will definitely look into other medications. Thank you for sharing!!
Foggy-Hollow
GLP-1 Enthusiast
Your welcome. Sounds like you’ve made some big changes already, Nice Work.
I’m making guesses on how the glp-1s affect BP. I haven’t reviewed the trial data with an eye toward that. If it didn’t bother then that’s good news. (Keep an eye on it of course.)
I’ve been in slight denial about my BP, I take my meds every day but don’t monitor like I should. I hate the idea of popping a med forever and it feeds into wanting to lose weight. My mom was on a laundry list of meds and I don’t want that.
There’s a few running the tirz - reta stack with good results.
I’m making guesses on how the glp-1s affect BP. I haven’t reviewed the trial data with an eye toward that. If it didn’t bother then that’s good news. (Keep an eye on it of course.)
I’ve been in slight denial about my BP, I take my meds every day but don’t monitor like I should. I hate the idea of popping a med forever and it feeds into wanting to lose weight. My mom was on a laundry list of meds and I don’t want that.
There’s a few running the tirz - reta stack with good results.
I'm interested in any way to get my BP lower. High BP is genetic on my mom's side. I've exercised my entire life, trained and ran 2 marathons, several half marathons and more, I eat a decent diet and take vitamin supplements but none of it has made any difference. High BP showed up by the time I turned 40. I'm 63 now.
I've been on tirz since July to try to lose the extra 25 pounds that showed up after menopause that I could not shed no matter what.
My brother just lost about 40 lbs this past year (with a strict diet but no peptides) in response to high BP, onset type 2 diabetes and high cholesterol. His BP has not lowered at all even though all his other numbers are great.
I would think there's got to be some kind of peptide stack or combination that can help. I'm listening...
I've been on tirz since July to try to lose the extra 25 pounds that showed up after menopause that I could not shed no matter what.
My brother just lost about 40 lbs this past year (with a strict diet but no peptides) in response to high BP, onset type 2 diabetes and high cholesterol. His BP has not lowered at all even though all his other numbers are great.
I would think there's got to be some kind of peptide stack or combination that can help. I'm listening...
cygnus
GLP-1 Apprentice
Beet root can reliably drop BP 10/5. I don't know if it'd be contradictive of your current meds though. Came across this on Examine years ago and was surprised how well it worked...you can get tablets cheap on Amazon.
I have tried beet root but it just didn't work for me or I didn't take it for long enough... honestly I'm ok taking something for the rest of my life but would prefer it be natural and not BP meds.
Thank you! I agree, I also hate the idea of taking meds for ever. I thought the weightloss would let me off the bp meds, but nope. Same issue with metformin, PCP wants me to continue on that as well. The blood pressure meds make sense, but I'm so so about having to keep metformin. Just don't have a good reason for stopping.
keangkong
GLP-1 Specialist
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My cardiologist thought that my blood pressure was not likely to go down much. However, it ended up dropping enough that I was able to stop taking one blood pressure medicine. Blood pressure is weird. Thin, fit people can have high blood pressure.
Weight loss improved my lipids. It got rid of my fatty liver; I don't have a fatty liver according to the Fibroscan. My A1C dropped. However, I still take BP meds and use a CPAP machine. These weight loss medicines are great. However, they don't work perfectly for most of us.
HumanusExMachina
GLP-1 Apprentice
My blood pressure has gone down about 10 points. It's still high, but it's trending (very very slowly) in the right direction. The blood pressure meds my cardiologist has me on have done next to nothing, other than give me a side-effect that's controlled by taking extra zinc. Three-ish months on reta has been more effective than a year-and-a-quarter on blood pressure meds.
Are you still taking your BP meds? Also, what is your dose of reta?
HumanusExMachina
GLP-1 Apprentice
Yes, still taking the BP meds, even though they don't seem to do much. My reta dose recently went up to 3mg, so it's not a high dose that's affecting my blood pressure.
Has your pcp looked into secondary causes of htn? (Renal artery stenosis, pheochromocytoma, etc.)
I think these should also be ruled out as well
lessthanhalf
GLP-1 Apprentice
It is very very common to need more than one medication to control blood pressure, and it is a very good idea to get a home measuring device, they are pretty cheap on amazon. Trying to decide what to do with medication on just the numbers 154/90 and 139/76 would be difficult as one is borderline for increasing doses and the other is not ok and needs treatment, much easier with a bunch of readings you can average. I would suggest that high blood pressure be treated for what it is at the time, even if you hope it might go down with weight loss, which is fairly likely but not guaranteed. It is easy enough to stop blood pressure medication if it decreases with glp medication or weight loss. Undertreated high blood pressure is very common, and treating it reduces the chances of cardiovascular disease and strokes. There is lots of research showing tirzepatide and semaglutide reduce blood pressure and cardiovascular risk, but this has not yet been proven for retatrutide - it probably does as well, but it will be a few more years before it is definitive. Even with massive weight loss it is still possible to have hypertension that needs medication. Basic investigation of hypertension is something that is normally done, partly to exclude secondary causes as mentioned above, but also to determine if damage has been done by it, ecg, urine for protein , basic bloods for renal function etc. And obviously cholesterol and blood sugar for other potentially treatable risk factors.
miss-sanne
GLP-1 Enthusiast
Some thoughts :
It can be inherited hypertension , and no weight loss will help.
I would change medicine, and if needed do a 24 h bloodpressure test for 3 days.
Cut out sodium.
Consider checking your device, it needs calibrating from time to time. Buy a good quality one.
I use Emron.
It can also be related to kidneys, but let your GP look at it, or the doctor helping you.
Regular checkups include clinical examination, blood tests, urine, ECG.
And of course : I never adjust my patients medication based on consultation measurement, they are always higher, when I stare at them. 😉
Do a 3 day at home morning and evening, 3 times per session.
Just a few thoughts.
Merry X mas.🎄🎉🎁
It can be inherited hypertension , and no weight loss will help.
I would change medicine, and if needed do a 24 h bloodpressure test for 3 days.
Cut out sodium.
Consider checking your device, it needs calibrating from time to time. Buy a good quality one.
I use Emron.
It can also be related to kidneys, but let your GP look at it, or the doctor helping you.
Regular checkups include clinical examination, blood tests, urine, ECG.
And of course : I never adjust my patients medication based on consultation measurement, they are always higher, when I stare at them. 😉
Do a 3 day at home morning and evening, 3 times per session.
Just a few thoughts.
Merry X mas.🎄🎉🎁
No, they have not looked into secondary causes as far as I am aware.
I have tried the no sodium route along with protein and veggies, no carbs. In about 3 months ended up with hyponatremia with a sodium count of 118, an ambulance trip to ER and a 3 day stint in the hospital. I never would have thought that could even happen with eating so clean...
Just my experience but we all know each of our bodies are so unique.
My next route is to switch BP meds and possibly add a 2nd if needed. I've got to find a better balance.
I really like all the input on this thread- thanks!
Just my experience but we all know each of our bodies are so unique.
My next route is to switch BP meds and possibly add a 2nd if needed. I've got to find a better balance.
I really like all the input on this thread- thanks!
Can you list the specific model you use and if they have a large cuff version?
