How many people still use Sema?

CMA Pooky said:
I am at 4mg but stalled the past week+ and gained about 2 pounds. I will go to 5mg next dose. I am hoping not to eventually go above 6mg. I've read of several members who've had success stacking Reta and Sema. I think I will go that route at some point in February.
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You’re worried about receptor burnout, but you’re wanting to stack GLPs.

Common therapeutic range/benefits are realized around 6-8+mg.

A week stall isn’t much, 2lb could be water weight/scale variance.

The decision is yours, of course, I’m just looking at the logic of it.
 
I keep reading specifically not to stack sema and tirz. Has anyone else seen such advice/notes/dosing information?
 
Sema is GLP only, Tirz is GLP and GIP. Tirz GLP action is considerably weaker than sema, maybe 1/2-2/3 weaker.

You could stack, but I don’t see the benefit unless the GIP agonizing is too much… maybe hypoglycemia?
 
CMA Pooky said:
I have been on Reta for over 2 months now and am thinking of adding Sema as I get the hunger pangs on Reta usually around 4 days after taking my Reta dose. Any opinion or thoughts on what my starting Sema dose should be since I am already accustomed to being on Reta? I was thinking .5mg possibly?
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Are you still losing? I tried reta long after hitting goal. My hunger increased significantly and my weight increased for I think the first two weeks but went right back to my new normal and stayed there. We are all so different. Even though it's pretty trendy just let the reta do it's thing. If you really want to pin more things you always have that option later.
 
mlke6 said:
Are you still losing? I tried reta long after hitting goal. My hunger increased significantly and my weight increased for I think the first two weeks but went right back to my new normal and stayed there. We are all so different. Even though it's pretty trendy just let the reta do it's thing. If you really want to pin more things you always have that option later.
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I stalled and gained about 2 pounds over 1+ weeks. I just upped my dose to 5mg so hoping I will resume losing weight again. Will give it some more time (maybe a full month) before adding anything else if no additional results by then.
 
I still use it.

Sema, and dulaglutide and liraglutide were the only ones around just a few short years ago so sema is what I started on because there were not many other choices. It worked for me so I didn't really feel the need to try reta and the other ones yet. I figured they'd be there if sema stops working I have something else to try.
 
MeedzMoar said:
I keep reading specifically not to stack sema and tirz. Has anyone else seen such advice/notes/dosing information?
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When I was looking to stack due to slowing weightloss on tirzepatide, most of the advice I received online was to stack reta. I hadn't found my way here, so that wasn't possible at the time. So, I bought some semaglutide.

The general advice I've read is to slowly go up on sema and as you reduce tirz. And to go slow and easy and see how your body responds. The response for me has been:

June 1 - Dec 1 = 27 lbs lost ~ 1lbs per week

Dec 1 - Feb 2 = 20 lbs lost ~2.5lbs per week

Started stacking about 12/1, so it definitely broke the slowing weightloss stall and put me back on track. I haven't reduced my tirzepatide dose and pin 1mg of sema on day 3.
 
CMA Pooky said:
I stalled and gained about 2 pounds over 1+ weeks. I just upped my dose to 5mg so hoping I will resume losing weight again. Will give it some more time (maybe a full month) before adding anything else if no additional results by then.
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Hi. I want to make sure I understand your post. Did you increase Sema to 5mg on your RS? I've seen they are studying higher Sema dosing.
 
First let me say don't judge

Been on Sema since Dec. Pharmacy stuff, and now compounded from a subscription service. For the last few weeks I've been topping up halfway thru the week with gray tirz. The reason is my husband is very against the gray market. He's watched the news reports about Chinese peps and peptide parties where people pin any and everything and then get sick. He loves me too much to endorse that risk. So for now he's paying for the subscription Sema. That's fine and I appreciate it but I am keeping the tirz from him. I mean if he checked the fridge closely he would figure it out but I haven't told him.

I bought one 30 mg kit and it's gonna last a long time at this rate. I'm doing .50 Sema once a week and then 1.25 tirz twice during the week. It's working well. I do wonder what it would be like to completely switch to the tirz but Sema at no cost without a mad husband is working fine.
Also I have to add that I'm 59 started at 322 and CW is 302.
 
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Started with Sema around 18 months back. Switched to Tirz around 12 months back and now considering switching to Reta.
 
Grogu said:
When I was looking to stack due to slowing weightloss on tirzepatide, most of the advice I received online was to stack reta. I hadn't found my way here, so that wasn't possible at the time. So, I bought some semaglutide.

The general advice I've read is to slowly go up on sema and as you reduce tirz. And to go slow and easy and see how your body responds. The response for me has been:

June 1 - Dec 1 = 27 lbs lost ~ 1lbs per week

Dec 1 - Feb 2 = 20 lbs lost ~2.5lbs per week

Started stacking about 12/1, so it definitely broke the slowing weightloss stall and put me back on track. I haven't reduced my tirzepatide dose and pin 1mg of sema on day 3.
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What tirz dose currently? I’ve been considering adding a small amount of sema at day 3. On 10mg Tirz. Do you notice the sema?
 
agussie said:
What tirz dose currently? I’ve been considering adding a small amount of sema at day 3. On 10mg Tirz. Do you notice the sema?
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I’m currently taking between 16 and 17 mg of tirzepatide on Fridays and then about .5 to 1mg of semaglutide on Mondays depending on my mood and feeling.

Yes, I definitely feel the semaglutide and I love how it feels. The stack also broke a stall I was experiencing. But I waited to stack until I maxed out on tirzepatide.
 
Never tried Sema, but all the anecdotal feedback from friends, family, friend-of-a-friend, etc was a range of stomach discomfort, nausea, "hungover feeling", that drove them away from it (probably the cost as well if the experience is challenging).

Having only tried Reta, for a limited 6-week window, my feedback to them is "go get ya some!"

Just reading this forum, you can see the range of reactions both positive and negative, so to each their own. One size fits all generally fits no one well.
 
As of today's weigh-in I've lost 106lbs in 9 months mostly on sema. The up front appetite supression and elimination of food noise is key for me. OTOH a diabetic family member had to stop at the minimum dose after 4 weeks because he kept getting sent home from work due to nausea and vomiting.

The past couple months I started stacking with tirz and cag, currently at Sem 7, Cag 3, Tirz 10 mg /wk. I have another 55 lbs to lose to reach my goal. The cag is in the mix mainly because I got 50% off on a couple of underfilled kits. When it runs out I'll try upping the sem which I think for me is the primary factor in continued weight loss. Maybe consider adding ret later if needed.
 
Know1 said:
As of today's weigh-in I've lost 106lbs in 9 months mostly on sema. The up front appetite supression and elimination of food noise is key for me. OTOH a diabetic family member had to stop at the minimum dose after 4 weeks because he kept getting sent home from work due to nausea and vomiting.

The past couple months I started stacking with tirz and cag, currently at Sem 7, Cag 3, Tirz 10 mg /wk. I have another 55 lbs to lose to reach my goal. The cag is in the mix mainly because I got 50% off on a couple of underfilled kits. When it runs out I'll try upping the sem which I think for me is the primary factor in continued weight loss. Maybe consider adding ret later if needed.
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Congratulations! That's freaking fantastic! I've lost 103, but it took me 14 months, so you're crushing it! I'm stacking a low dose of sema with 16mg of tirz, but have been contemplating backing off the tirz a little and increasing the sema.

I'm all for pushing past FDA limits, but just wondering how much higher you plan on going on the sema?
 
Grogu said:
Congratulations! That's freaking fantastic! I've lost 103, but it took me 14 months, so you're crushing it! I'm stacking a low dose of sema with 16mg of tirz, but have been contemplating backing off the tirz a little and increasing the sema.

I'm all for pushing past FDA limits, but just wondering how much higher you plan on going on the sema?
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We've both lost about the same amount, for my part I feel so much better. I don't need oxygen supplementation anymore, a pressure wound I had for years completely healed, my legs aren't as swelled up covered with leaking water blisters. It's like a new lease on life.

As far as how much higher, there are published results of trials investigating weekly doses of sema up to 16 mg/wk (paper attached). Hopefully I won't need to push it that high, since as I get close to my goal weight I'll need to cut back to some maintenance level. I wouldn't be adverse to 10-12 mg/wk but only if I can't maintain at least 1-2 lbs/wk average weight loss smoothed by month.
 

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Thank you for the article. I started on Sema and would happily have stayed on it if I hadn't maxed out at 2.4. If/when there is enough data to support its higher dosing, I will seriously consider going back to it even though it is harder to find and a testing group is virtually unheard of in the places I've seen testing groups.
 
MeedzMoar said:
Thank you for the article. I started on Sema and would happily have stayed on it if I hadn't maxed out at 2.4. If/when there is enough data to support its higher dosing, I will seriously consider going back to it even though it is harder to find and a testing group is virtually unheard of in the places I've seen testing groups.
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The data is basically there by now, with the STEP UP study phase 3b. Based on it, in the EU the 7.2 mg-dose was officially approved few days ago, the UK had done it a while before.

I hear you on the testing group issue... 😐
 
Enyola said:
The data is basically there by now, with the STEP UP study phase 3b. Based on it, in the EU the 7.2 mg-dose was officially approved few days ago, the UK had done it a while before.

I hear you on the testing group issue... 😐
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Oh, I hadn't looked into global approvals on higher dosing. Thank you!!!! I don't think the FDA is any more careful; in fact they are probably less careful.
 
I don't know if there are big differences, the EMA (European Medicines Agency) often agrees with decisions of the FDA. In this case, Novo Nordisc applied for approval in the US much later, just in november, while in the EU in july already.
 
MeedzMoar said:
I keep reading specifically not to stack sema and tirz. Has anyone else seen such advice/notes/dosing information?
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In the pass I stacked 0.1mg of Sema with 6mg of Tirz
Sema, even at these low mg, worked very well with me regarding hunger suppression
Now I'm moving from Tirz to Reta and stopped Sema.. But after Tirz get out of my body I will include sema again.
 
Lyophilized said:
In the pass I stacked 0.1mg of Sema with 6mg of Tirz
Sema, even at these low mg, worked very well with me regarding hunger suppression
Now I'm moving from Tirz to Reta and stopped Sema.. But after Tirz get out of my body I will include sema again.
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I just took .75mg of sema about an hour ago and I'm really feeling it. I took 15mg of tirzepatide this past Friday, so I agree, that even at very low doses of sema I personally feel the effects.

I've been going back and forth where to go with my stack and I woke up this morning and decided that I'm doubling down on the sema. Going to start increasing my dose of sema weekly as I decrease the tirzepatide. But I've been on tirzepatide 14 months at this point and over the max FDA dose for awhile.
 
Looks like stacking Sema with newer glp/gip happens a good bit. Sema tested well the first time around. Retest with grey did not which was disappointing, frustrating and temporarily bore analysis paralysis. And now with higher dosing levels moving through testing - and approved in the EU - it seems promising.
 
Grogu said:
I just took .75mg of sema about an hour ago and I'm really feeling it. I took 15mg of tirzepatide this past Friday, so I agree, that even at very low doses of sema I personally feel the effects.

I've been going back and forth where to go with my stack and I woke up this morning and decided that I'm doubling down on the sema. Going to start increasing my dose of sema weekly as I decrease the tirzepatide. But I've been on tirzepatide 14 months at this point and over the max FDA dose for awhile.
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What for me it's curious is that when I was with high doses of Sema (1mg to 2mg) I didn't feel the hunger suppression as 6mg of Tirz with 0.1mg of Sema
The combination was very good
Just switched to Reta because when I move up on Tirz (with the same dose of Sema) the fatigue was very strong... And I didn't like that
 
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