amynurse
GLP-1 Apprentice
Oh! I forgot to mention the KLOW! Been taking each individual pep to equal KLOW (substitute GHK Basic for CU) for a year, along with selank, and epitalon twice a year. My skin has never looked better!
Hey over 50 ladies! Get in here, Let's talk
- Thread starter chunkyTN
- Start date
FarmgirlRebel
GLP-1 Enthusiast
Hi All!
Love reading everyone's "pilgrimage" into better health.
61 yrs at the moment.
SW: 320
CW: 170
Not all was lost on Tirz/GLP. I had bariatric surgery in 2021, called a biliopancreatic duodenal switch. Which basically cuts out most of your stomach and re-routes your intestines to give you a life long malabsorption component...yes, it is extreme and if GLPs had been a thing back in 2021, I would have opted for that before this surgery.
Anyway, post surgery I got down to 180lbs, then ended up with a gangrenous gallbladder, that turned into sepsis and septic shock, and by the end of that run, I was very thin.
Drugs, steriods and everything else they gave me to keep me going, popped my weight back up to 230lbs, with a ton of inflammation.
Desperate and sick, I started to look into GLPs and the greater peptide world for some answers. Happy to say, Tirz got me down to 170 as of now...I also do NAD+ routinely. I have also ran a cycle of Epithalon. KLOW (individual vials/not blend), TA-1. Currently I am doing another cycle of KLOW to try and help with an old, chronic muscle injury.
My staple however is Tirz/NAD+ and GHKcu .
I have lots of lose saggy skin ...but I don't care. I love being able to swing a leg over my horses and be able to ride for hours and hours. Spanx is my friend, lol
Love reading everyone's "pilgrimage" into better health.
61 yrs at the moment.
SW: 320
CW: 170
Not all was lost on Tirz/GLP. I had bariatric surgery in 2021, called a biliopancreatic duodenal switch. Which basically cuts out most of your stomach and re-routes your intestines to give you a life long malabsorption component...yes, it is extreme and if GLPs had been a thing back in 2021, I would have opted for that before this surgery.
Anyway, post surgery I got down to 180lbs, then ended up with a gangrenous gallbladder, that turned into sepsis and septic shock, and by the end of that run, I was very thin.
Drugs, steriods and everything else they gave me to keep me going, popped my weight back up to 230lbs, with a ton of inflammation.
Desperate and sick, I started to look into GLPs and the greater peptide world for some answers. Happy to say, Tirz got me down to 170 as of now...I also do NAD+ routinely. I have also ran a cycle of Epithalon. KLOW (individual vials/not blend), TA-1. Currently I am doing another cycle of KLOW to try and help with an old, chronic muscle injury.
My staple however is Tirz/NAD+ and GHKcu .
I have lots of lose saggy skin ...but I don't care. I love being able to swing a leg over my horses and be able to ride for hours and hours. Spanx is my friend, lol
Good-Heart6425
GLP-1 Enthusiast
I put pearl barley with a smidgen of lentils in my pressure pot for 15 minutes! The complex carbohydrate with legume protein is delicious, low glycemic index, and filling. Rice takes 20 minutes and is high glycemic index so I substitute with the barley.
Good-Heart6425
GLP-1 Enthusiast
Yes, after 6 weeks compounded Tirz, sleepiness mode prevailed. Probably due to fasting hypoglycemia, but my logic circuits were shorting out too. Now at 10 months, at goal weight with multiple comorbidities quantitatively declined: brain fog, knee pain, pre-diabetes, pre-hypertension, reflux, irritable bowel, obstructive sleep apnea, keratoses and skin tags! Improved mood and energy.
Have you tried toasted buckwheat? Soooo good and quick in the pressure cooker! I fluff it up and add a dash of olive oil, a sprinkle of dill and salt and pepper. If I feel fancy, I add a fried egg on top.
Good-Heart6425
GLP-1 Enthusiast
Wow, I’m gonna get some buckwheat to try! Thank you
miche52
Recently Joined
🚫No Source Discussion🚫
52 year old. Started using compound GLP in Jan 2023. Started at 195. Currently at 163. My lowest has been 155. I been a yoyo dieter since my 20s. Would always drop weight fast but put it back on. Glps really have helped break the diet mentality. I haven't hit menopause officially yet but my instinct says this is the year (no cycle since September). I've been using HRT for almost a year which has helped with my symptoms. I get bloating from HRT but I'll take it over the mood swings, anxiety, no sleep and hot flashes.🤷
I started on sema and lost very slow. Switched to tirz last year and I have less food noise. The highest dose I've used is 6 mg (grey). I've been a slow responder. Initially I was bummed but Im now grateful. I lifted weights a lot more the first year or so but not as much now. I walk 5-6 days a week which makes a difference in I feel overall.
I can't imagine what I would look like but more importantly how I would feel mentally and emotionally today had I not started using a glp. It's truly been a life saver.
MsGizmo
GLP-1 Enthusiast
Now coming to the end of the SS-31 stage. The only thing I see is improved sleep. That probably due to the NAD+. But to be fair, if something is working in the background and healing something at the cellular level .. would I actually be able to tell the difference? After this protocol is over I intend to take a round of epitalon ... something that is supposed to improve the lifespan of my cells. For that I just have to trust the science.
MsGizmo
GLP-1 Enthusiast
I love adding barley to my stew. My family loves it.
Sidney
GLP-1 Novice
🚫No Source Discussion🚫
I am 50 yo. 5’4” and about 188 lbs at highest and had high cholesterol/LDL that was impetus to start my health journey in 2021. I started with diet changes and added running and weight lifting over time. Lost 60lbs (to 124 lbs) in 18 months and cholesterol dropped to normal levels. Since then I hit perimenopause and my menstrual cycle became irregular and I started gaining weight (increased 15 lbs) and cholesterol started to creep up again.
Started Reta at 0.5 mg in September but was training for half marathon and it was interfering with long runs so I stopped for about 6 weeks until I completed the HM. I resumed Reta in November and lost 1-2 lbs per week since then. Today I hit my lowest weight of 124 lbs.
I am currently at 1.5 mg Reta / week. My goal weight is 120 lbs which I should hit in next 4 weeks, so I am already planning for what maintenance looks like (tapering down and maybe spacing dose). I do have some tolerable side effects and I am looking forward to reducing dose. I had to return to office about the same time I resumed Reta in November and really fell off running and weight training. I am really hoping to figure out time management and adding weight training back in when I am at maintenance and focus on body recomposition.
Started Reta at 0.5 mg in September but was training for half marathon and it was interfering with long runs so I stopped for about 6 weeks until I completed the HM. I resumed Reta in November and lost 1-2 lbs per week since then. Today I hit my lowest weight of 124 lbs.
I am currently at 1.5 mg Reta / week. My goal weight is 120 lbs which I should hit in next 4 weeks, so I am already planning for what maintenance looks like (tapering down and maybe spacing dose). I do have some tolerable side effects and I am looking forward to reducing dose. I had to return to office about the same time I resumed Reta in November and really fell off running and weight training. I am really hoping to figure out time management and adding weight training back in when I am at maintenance and focus on body recomposition.
vjorvj5150
GLP-1 Novice
🚫No Source Discussion🚫
2/16/2026 current weight 200
HZM808
GLP-1 Apprentice
Hi there, I was trying to search for info on if it makes sense to stack Glutathione and Melanotan 1 together and came across your post. Currently am pinning 1200mg of Glutathione once a week (this is my 5th week) and I think I'm seeing the skin lightening benefits, which I love. However, with summer coming quick to FL, I was thinking of trying the melanotan 1 as I'd love to see if the sun protection would help with my rosacea for which sun is the biggest trigger.
I'm a bit nervous as I do have melasma and some poikiloderma but I always start with the low n slow approach and have read it'll reverse. I've been on Klow for 16 wks and am cycling off that, so skin benefits could have been from that finally kicking as well as getting more consistent with melanin inhibitor skin care in prep for a peel I just did last week (mandelic bc I have rosacea).
I've done some searching but haven't really come up with anything. My concern is the Gluta and Melanotan will compete with each other in the skin dept. Did you find anything about that or did you notice anything that seemed that way?
CNCCurrency
GLP-1 Specialist
I follow a brit on youtube called the enhanced man. He runs cycles of epitalon and gets his blood work done thru epigenectics I believe and he show the improvements in telomere lengths and his biological age keeps going down with each cycle. You should check out his videos he is very informative.
Wecandothis
GLP-1 Apprentice
I am much older than you. Also had hysterectomy when I was 56. These work. I am at 127. I walk on the treadmill at least 30 minutes a day. I lift five pound weights at least two times a week. I do Reta with 2.5 tirz. Tirz helps with inflammation so I don’t want to stop it. I tried stopping it but felt like everything was hurting. I do have some skin sagging on arms and legs but that can’t be helped. Tirz with a little sema might be the winning ticket for you, I have done cagri, tirz and Reta all at once too. When I stalled I needed the extra boost. Just make sure you lift some weights, otherwise you are going to lose way too much muscle. And it’s very hard to get it back.
chunkyTN
GLP-1 Apprentice
Hi Wecandothis! I love your name. Yes, I added weight lifting 3 times a week along with riding my stationary bike every day (doing 2 miles a day now!). I had to start slow but it's getting better.
The GLP1s have helped with my inflammation too. I haven't progressed to Reta yet. I'm doing Sema and a tirz booster and that's working for now. It's also a budget option. I'm sure I'm gonna have saggy skin but it's just part of it.
My Mom was overweight and after she retired she just stopped doing anything. She got lymphodema and that led to a bunch of other things. Eventually she got a wound on her leg, didn't follow doctors orders, went septic and died. I AM NOT going to go that way. I'll take the saggy skin.
FarmgirlRebel
GLP-1 Enthusiast
Question for you ladies.
Anyone stack Cagri with the GLP with success. I'm wondering if introducing a small amount of Cagri instead of titrating up on Tirz might be a better way to go.
I have no need to titrate up just yet, I'm losing well and staying satiated at 5mg...but thinking ahead.
Anyone stack Cagri with the GLP with success. I'm wondering if introducing a small amount of Cagri instead of titrating up on Tirz might be a better way to go.
I have no need to titrate up just yet, I'm losing well and staying satiated at 5mg...but thinking ahead.
FlowerFairy
GLP-1 Enthusiast
You know I never thought about that! I’m ultra pale and Melanotan-1 did nothing. I switched to MT-2, and now instead of alabaster I’m lightly tanned. I never considered that my glutathione might be reversing my tanning effect.. I take 200 mg daily of the glutathione.. now I’m wondering if that’s why the MT didn’t work! I’ll have to stop the glutathione for a while to see if it works any better..
Thank you for pointing that out- I managed to miss it.. 😳
CNCCurrency
GLP-1 Specialist
i did mt 1 and tanned nicely and now using 200 glut 3 times a week with no loss of tan
FlowerFairy
GLP-1 Enthusiast
I wonder if I took a break and used it to tan I’d have better results? I know maintaining is supposed to be easier than starting out..
(And Thank You!!)
CNCCurrency
GLP-1 Specialist
I do a shot once a week to maintain. Have had a nice tan for 5 months straight
FlowerFairy
GLP-1 Enthusiast
If I took a photo of my skin that is mildly tanned, you’d think I have no tan at all. But my natural skin tone is alabaster glow in the dark white…. 🫤
CNCCurrency
GLP-1 Specialist
Mt 1 will only tan you as much as you would naturally tan. Now Mt 2 is different
I’ve been curious as to the differences in Mt1 and Mt2 - if you’re willing to explain.
Wecandothis
GLP-1 Apprentice
I added .3 Cagri for awhile and it made my weight start up again after a stall. I didn’t need to increase the tirz or Reta while I was doing the Cagri
Wecandothis
GLP-1 Apprentice
Saggy skin is no big deal. I love being thin and the skin doesn’t bother me. You will do this!
FlowerFairy
GLP-1 Enthusiast
Yes, I switched to MT2 because I didn’t see anything with MT1. I CAN tan- but only if I’m taking g paba to prevent burning. The best tan I ever got was when I spent 2 weeks at the beach in middle school. My mom made me take the paba and Ihad a real tan. Came home, no daily sun exposure and it all peeled off. BOO.
FlowerFairy
GLP-1 Enthusiast
I was you about 2 years ago- except Sema did nothing for me. Switched to Tirz and lost slow but steady until around January of last year- switched to Reta because on Tirz I was losing, but I slept every minute I could and had horrible constipation. Plus nothing tasted good. I titrated up on Reta and down on Tirz, I didn’t just switch. Once on full Reta Ihad some stalls; I’d made it to 40 lbs from goal and stopped. I was really frustrated, but my body was changing even tho I wasn’t losing. I decided to go back on the Tirz-Reta combo and I’m 20 lbs from goal.. and thinking about changing my goal again.
If Sema is working, stay on it- that gives you more options in case you max out on Sema and need Tirz and Reta. If Ihad not had the horrible sides from Tirz alone, I’d have stayed on Tirz for the duration- I was only on 5 mg.
And for full disclosure- I had a modified duodenal switch in 2001. Lost 120 lbs and stopped because my surgeon gave me a proximal bypass instead of the distal bypass the surgery describes. He only admitted this after I jumped through hundreds of hoops, because I was only halfway to goal (Ihad chosen a DS because it has the highest success rate for the super morbidly obese). He then pronounced me a success because I’d lost over 100 lbs and basically washed his hands of me. I kept that weight off for 15 years until a doctor put me on a med that made me gain 50 lbs in a month. One thing I did appreciate about my surgery- I couldn’t lose weight no matter what I did (including medical fasting), but I also didn’t gain. Until that med. And I couldn’t lose that 50 lbs. I was not a happy camper- and that doctor was angry that i refused to take any more because of the weight gain, even though it didn’t fix the issue it was prescribed for. So- my journey went like this;
Age 3- my weight tripled in a month, no change in intake, diet, activity- pediatrician said I was about to have a growth spurt; I’m still waiting. I was active, involved in sports, but fat. Played soccer in high school and college, played softball, was on swim team- but fat. Got up to 320, despite trying everything- most were successful to a point but it all came back plus more. Seemed to average about 10 lbs a year and was getting desperate. I researched surgery because nothing else worked and the duodenal switch with biliopancreatic diversion seems the safest and the fewest side effects and best outcomes. So on May 30 2001 I had the surgery. I weighed 419 the day of surgery. Lost to 274, maintained that until 2015, the medication put me back to 320. Until I found Tirz, there I stayed. Now I’m down to 220, original goal was 200, now considering going lower because I’m still pretty fluffy. So-
Highest weight- 419
Post DS- 274
Post med gain- 320
Current weight- 220
Goal weight- debating 170.. original 200
So- hang in there and have faith. If you have questions, ask me!
chunkyTN
GLP-1 Apprentice
I'll be 100% honest about the Sema. My husband is paying for it from a compound pharmacy and he doesn't know about the gray. So I do the sema shots and I top off with tirz for the food noise.
I know I probably should tell him but he's really paranoid about the gray stuff and I'm doing really well with what I have going on.
Hotdaddy444
Recently Joined
🚫No Source Discussion🚫
I was told when I started and was incredibly nauseous to watch the amount of fat I ate - that it led to more nausea. I didn’t believe it. But now, 7 months in, I’ve found that it’s somewhat true. If I eat too much red meat, or pizza or anything greasy I’ll have nausea, even if i hadn’t just dosed. In the end I’ve settled on split dosing every 3 days and the nausea is manageable if I watch the high fat food. I’m 7 lbs from goal, and have lost ~40lbs
FarmgirlRebel
GLP-1 Enthusiast
Thanks for this...this is what I'm looking for as I don't want to max out if at all possible on the GLP
