I had been using ghkCu/basic 50:20 along with kpv injected first at the same site and some topical hydrocortisone for good measure… working my way up to 4.5mg/day divided doses… which was really working for stopping migraines… and there was no immediate sting at all but I would get stinging 2-5 hours later in the same leg at other pervious injection sites where I had bruises. I took this to mean that some sort of healing was going on.
About a week in, I was starting to get delayed itching and a persisting bump deep down that was itchy (not hives) at the injection site. I switched to using abdominal sq sites and the bumps all got much less. Then a few days after, my qd lira and ss31 injection sites (other leg) also developed delayed itchy bumps. And my scalp had been increasingly itchy as well as my overall skin. I have been a fairly environmentally allergic person in the past and due to the recent rains we are having an early spring allergy season here so that eas adding in.
This is still just one organ system (skin) so not anaphylaxis. It still seemed like a mast cell reaction, a mechanical irritation, but was extending to make me more sensitive to actual allergies too, as can happen. I started wondering if it was my actually pretty crappy quality needles and pen needles, maybe the rubber stoppers, or something in all the products (my rather $$$$ Rx’d generic lira pen actually came from CN so I am very suspicious it is also recon’d lyo’d pep).
I had talked to someone with a history of similar reactions who had taken 5 days of high dose brand name Zyrtec antihistamine (4 pills a day, but do check with your doctor to make sure you’re not missing or covering up increased anaphylaxis risk, which can be the case with those with atopic dermatitis or mast cell disorders, and mast cell disorders are apparently underdiagnosed since 50% of people with history of wasp sting anaphylaxis im one study turned out to have a mast cell clonal disorder ).
Continuing, with my neffies to hand, I am on day 3 of antihistamines and only 1.5mg of ghk and can say that it has given me relief from my insomnia 🤣 and I’m less itchy but still getting new itchy welts. I restarted topical hydrocortisone which helps.
I think I might try ghk basic alone next, on the copper theory, but I am a little worried that I might need to take a break from all injections to let my mast cells settle down if literally everything is triggering this.
Is anyone having this ghk reaction while also on tirz? Tirz is likely very good at suppressing mast cell inflammation. Would you please let us know if you take tirz and ghkcu and whether you have any kind of isrs?
Anyone getting a spreading reaction should be very cautious and quite likely more cautious than I am being. Antihistamines DO NOT treat or prevent anaphylaxis. Anyone with previous anaphylaxis is likely at higher risk for another episode. Epi does not save everyone who gets anaphylaxis!
