Joe Rogan with Brigham Buhler on all things health with focus on peptides

sfkid

sfkid

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Podcast just release with Brigham Buhler , CEO of ways2well.
Some interesting topics:

peptides and what it's going to mean for the industry once they're approved.
Big Pharma interventions around peptides
Longevity
Testosterone Therapy and myths around prostate cancer.

and many other interesting topics around preventative health and peptides specifically.

View: https://www.youtube.com/watch?v=gU6yFAeDsJ0
 
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Really interesting info. I know there are safety issues with peptides that should be improved but as soon as the government starts to regulate them, I see them being even more expensive and out reach for many people. The single vial online sellers are often too expensive for many people and compounded would be even more. It may ,however, reduce the liability factors for doctors to be able to prescribe it as many functional doctors don't want to get involved.
 
It was interesting. I listened to the first half and might finish it tomorrow. What struck me as odd was that the peptide guy didn’t put the > 500 lb jelly roll on a weight loss peptide?? And he came up with some protocol to get him to lose 250lbs. They also seemed to talk about glp-1s in a negative light as if it’s not a peptide that has helped more people than all the other peptides combined. Pretty weird to me.

Still interesting but not sure I trust this guy.
 
CornPop said:
It was interesting. I listened to the first half and might finish it tomorrow. What struck me as odd was that the peptide guy didn’t put the > 500 lb jelly roll on a weight loss peptide?? And he came up with some protocol to get him to lose 250lbs. They also seemed to talk about glp-1s in a negative light as if it’s not a peptide that has helped more people than all the other peptides combined. Pretty weird to me.

Still interesting but not sure I trust this guy.
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Well if they put people on GLPs they would lose a ton of upsell. He is after all CEO of company that needs to make 💰 .
 
sfkid said:
Podcast just release with Brigham Buhler , CEO of ways2well.
Some interesting topics:

peptides and what it's going to mean for the industry once they're approved.
Big Pharma interventions around peptides
Longevity
Testosterone Therapy and myths around prostate cancer.

and many other interesting topics around preventative health and peptides specifically.

View: https://www.youtube.com/watch?v=gU6yFAeDsJ0
Click to expand...
Just added this straight to my playlist – thank you! Brigham Buhler always cuts through the noise. Really curious about the regulatory outlook on peptides and what formal approval would actually mean for the community.
 
Thanks for the heads up! I actually first heard about peptides in a previous episode and it led me pursue more research.
 
It was a great interview, highly recommend anyone in the peptide space listen to this and the previous ones with him. A lot of good discussion and thoughts on the future of the wellness market from someone actively participating in it.
 
sfkid said:
Well if they put people on GLPs they would lose a ton of upsell. He is after all CEO of company that needs to make 💰 .
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That’s what I’m saying. Seems like he’s just waxing poetic about big pharma hogging all the $, but he’s trying to do the same thing with wellness clinics. He repeatedly calls it black market and acts like the only way to get peptides is through a wellness clinic when he knows he gets the stuff for his clinic from ….. china
 
CornPop said:
It was interesting. I listened to the first half and might finish it tomorrow. What struck me as odd was that the peptide guy didn’t put the > 500 lb jelly roll on a weight loss peptide?? And he came up with some protocol to get him to lose 250lbs. They also seemed to talk about glp-1s in a negative light as if it’s not a peptide that has helped more people than all the other peptides combined. Pretty weird to me.

Still interesting but not sure I trust this guy.
Click to expand...

My functional MD still believes its all about garbage in and garbage out, eat healthy and work out and you won't need GLP's which is true for many but not all when it comes to weight.. I liked the part about genetic testing. I have tried Tirz and Reta. TIrz was a big zero and raised my insulin resistance and I didn't lose a pound. Reta reduced my cholesterol levels and reduced IR and dropped my A1c by .1 and while I have lost a few pounds, the weight is not coming off very quickly. I would love to know what's going on. I'm already up to 10mg and it wasn't until 10 did I get any weight loss or feel any suppression.
 
toologic said:
My functional MD still believes its all about garbage in and garbage out, eat healthy and work out and you won't need GLP's which is true for many but not all when it comes to weight.. I liked the part about genetic testing. I have tried Tirz and Reta. TIrz was a big zero and raised my insulin resistance and I didn't lose a pound. Reta reduced my cholesterol levels and reduced IR and dropped my A1c by .1 and while I have lost a few pounds, the weight is not coming off very quickly. I would love to know what's going on. I'm already up to 10mg and it wasn't until 10 did I get any weight loss or feel any suppression.
Click to expand...
GLPs are not some "black magic" that makes the weight come off magically. They suppress appetite which SHOULD put you in a caloric deficit which will make your body use the stored fat as energy which will make you lose weight.

if you are not losing any weight, you might not be in a caloric deficit. Maybe you need to move a little more (more steps).

If you are not feeling any appetite suppression then that could be something else (bad batch of reta? / not a hyper responder to GLPs?). Maybe you just need a higher dose and a little time for it to work its way in your body...
How long have you been on Reta?
 
toologic said:
My functional MD still believes its all about garbage in and garbage out, eat healthy and work out and you won't need GLP's which is true for many but not all when it comes to weight.. I liked the part about genetic testing. I have tried Tirz and Reta. TIrz was a big zero and raised my insulin resistance and I didn't lose a pound. Reta reduced my cholesterol levels and reduced IR and dropped my A1c by .1 and while I have lost a few pounds, the weight is not coming off very quickly. I would love to know what's going on. I'm already up to 10mg and it wasn't until 10 did I get any weight loss or feel any suppression.
Click to expand...
Yeah I wonder if there is something that comes down to genetics. For what it’s worth I know someone who had to go to 15 mg of legit zepbound before they started to get good appetite suppression.

I think the whole calories in / calories out argument is so dumb. People will say you can eat only twinkies and as long as you’re in a deficit you will lose weight. Okay that’s true in theory but we live in reality and no one has ever lost weight eating twinkies.
 
CornPop said:
It was interesting. I listened to the first half and might finish it tomorrow. What struck me as odd was that the peptide guy didn’t put the > 500 lb jelly roll on a weight loss peptide?? And he came up with some protocol to get him to lose 250lbs. They also seemed to talk about glp-1s in a negative light as if it’s not a peptide that has helped more people than all the other peptides combined. Pretty weird to me.

Still interesting but not sure I trust this guy.
Click to expand...
Wallah that mf Jelly Roll is on some Reta. I refuse to believe otherwise

Source; My ass
 
I swear I read that he was on a GLP1 or another weight loss medication, so I don’t know why Rogan keeps saying he did it without medication
 
toologic said:
My functional MD still believes its all about garbage in and garbage out, eat healthy and work out and you won't need GLP's which is true for many but not all when it comes to weight.. I liked the part about genetic testing. I have tried Tirz and Reta. TIrz was a big zero and raised my insulin resistance and I didn't lose a pound. Reta reduced my cholesterol levels and reduced IR and dropped my A1c by .1 and while I have lost a few pounds, the weight is not coming off very quickly. I would love to know what's going on. I'm already up to 10mg and it wasn't until 10 did I get any weight loss or feel any suppression.
Click to expand...
Maybe try sema? It seems very good for appetite suppression. I take 1 mg of it and can barely eat.
 
CornPop said:
Yeah I wonder if there is something that comes down to genetics. For what it’s worth I know someone who had to go to 15 mg of legit zepbound before they started to get good appetite suppression.

I think the whole calories in / calories out argument is so dumb. People will say you can eat only twinkies and as long as you’re in a deficit you will lose weight. Okay that’s true in theory but we live in reality and no one has ever lost weight eating twinkies.
Click to expand...
I think some people are metabolically blessed and never gain weight and think that these glp1's are just a gimmick
 
CNCCurrency said:
I think some people are metabolically blessed and never gain weight and think that these glp1's are just a gimmick
Click to expand...

I started watching people eat when I was in 3rd grade. Yes some people can eat what they want and never gain a pound. I have a SIL that claims she is thin because she doesn't eat sweets. However she orders a pizza, eats 2 slices with a glass of coke and then proceeds to open up some chips and dip and drink another glass of coke. If you ask her how many calories or how many grams of fat,carbs, protein and sugar she just ate, she has no clue because she never had to pay attention to weight problems.
 
jungletech said:
Maybe try sema? It seems very good for appetite suppression. I take 1 mg of it and can barely eat.
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I may try it. I tried it for a month but I didn't feel anything. I did take tirz for 5 months and went up to 12.5. I might try adding cag or maybe survo.
 
sfkid said:
GLPs are not some "black magic" that makes the weight come off magically. They suppress appetite which SHOULD put you in a caloric deficit which will make your body use the stored fat as energy which will make you lose weight.

if you are not losing any weight, you might not be in a caloric deficit. Maybe you need to move a little more (more steps).

If you are not feeling any appetite suppression then that could be something else (bad batch of reta? / not a hyper responder to GLPs?). Maybe you just need a higher dose and a little time for it to work its way in your body...
How long have you been on Reta?
Click to expand...
That's the main issue that I"ve had with GLP's. THey are supposed to help suppress appetite. I was on Tirz for 5 months and up to 12.5. THe day after the first shot at 2.5 , I woke up and and had no appetite. That lasted for 4 days and then NOTHING for the next 5 months. I have been on Reta since last July and was up to 10mg/week in mid-Dec. I was waiting for more stock and was trying to ration what I had so I stayed at 10mg for 2 months and then all of a sudden, I start to get suppression. When my shipment came in I thought about going up more but stayed at 10 up until now and I'm starting to lose that suppression and will have to increase. At some point I"m afraid that it just won't work and I have alot of weight to lose and haven't made much progress. . Since the weather warmed up I have been walking more but that has a tendency to increase my appetite.
 
toologic said:
That's the main issue that I"ve had with GLP's. THey are supposed to help suppress appetite. I was on Tirz for 5 months and up to 12.5. THe day after the first shot at 2.5 , I woke up and and had no appetite. That lasted for 4 days and then NOTHING for the next 5 months. I have been on Reta since last July and was up to 10mg/week in mid-Dec. I was waiting for more stock and was trying to ration what I had so I stayed at 10mg for 2 months and then all of a sudden, I start to get suppression. When my shipment came in I thought about going up more but stayed at 10 up until now and I'm starting to lose that suppression and will have to increase. At some point I"m afraid that it just won't work and I have alot of weight to lose and haven't made much progress. . Since the weather warmed up I have been walking more but that has a tendency to increase my appetite.
Click to expand...
Are you doing 10mg once a week? Some benefit by splitting the dose twise weekjly or even more frequently...
 
sfkid said:
Are you doing 10mg once a week? Some benefit by splitting the dose twise weekjly or even more frequently...
Click to expand...
I take 5mg twice a week. When I first started I took my dose once a week and about 3 months ago started twice a week. Also when I do exercise, I get hungry and if I don't eat something I get massive sick headaches.
 
toologic said:
I take 5mg twice a week. When I first started I took my dose once a week and about 3 months ago started twice a week. Also when I do exercise, I get hungry and if I don't eat something I get massive sick headaches.
Click to expand...
Im not a doctor but that sounds like you have very low blood sugar. Have you done any blood work?
if not, the minimum I do is:
  • Hemoglobin A1C
  • Fasting plasma glucose
 
That sucks that some of you are having it not work after a time. I just have medication related hunger that is ravenous, but it seems combatible at normal doses.
 
sfkid said:
Im not a doctor but that sounds like you have very low blood sugar. Have you done any blood work?
if not, the minimum I do is:
  • Hemoglobin A1C
  • Fasting plasma glucose
Click to expand...
I am going for tests in late April. My last A1c was 5.5 and glucose 100. Not great but still in range. I take berberine before eating and since being on Reta I"ve tried to go off of it but when I eat even a small meal even with nothing but protein/fat, I would would start to fall asleep so I continue using the berberine. I tried using a CGM for a month to try and figure out what my glucose was doing but it was not showing anything out of the ordinary. THe only thing that would bring my glucose into the mid 80's is excercising.
 
His last appearance he complained about big Pharma wanting to come in and take control of peps. This episode he's wanting more regulations as more people are going gray. They both were talking about stem cell therapies and how they need to be here in the US, but talks about sending people to Mexico and Panama to receive them... kinda talking out of both sides of his mouth.
 
toologic said:
I am going for tests in late April. My last A1c was 5.5 and glucose 100. Not great but still in range. I take berberine before eating and since being on Reta I"ve tried to go off of it but when I eat even a small meal even with nothing but protein/fat, I would would start to fall asleep so I continue using the berberine. I tried using a CGM for a month to try and figure out what my glucose was doing but it was not showing anything out of the ordinary. THe only thing that would bring my glucose into the mid 80's is excercising.
Click to expand...
You're pre-diabetic based upon your A1c and fasting glucose. By the time those numbers reflect the issue you've been developing the condition for some time. Are you taking a GLP?
 
tendency said:
You're pre-diabetic based upon your A1c and fasting glucose. By the time those numbers reflect the issue you've been developing the condition for some time. Are you taking a GLP?
Click to expand...
yes. Tirz did nothing and Reta has helped my heart more than anything. Little weightloss on either of these two
 
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