Adding Cagrilintide to Tirzepatide

cythehun

cythehun

Recently Joined
🚫No Source Discussion🚫
Member Since
Mar 11, 2026
Posts
10
Likes Received
26
Location
Spokane, WA
United-States
I would like to hear from those who added Cagrilintide to Tirzepatide. What was your motivation? What dosing schedule did you follow? How are the results?

Currently I am on 10mg/week of Tirzepatide. While it is mostly working well, the on-going "food noise" is sabotaging my efforts to maintain my eating discipline. Before I continuing upping my TZ dose, I would like to see if adding Cagrilintide will provide the needed appetite suppression to allow me to meet my intake goals.
 
I’m up to 6 mg Tirz (started July ‘25 at 2.125mg) - added Cagri 6 weeks ago, trying to stay at 6 mg longer/a 2 day bridge to shot day.
The stuff works too good, at least for me. Other people are already at 1 or 2 mg with no problems.
A real struggle to eat for 3ish days after. Not nausea at all, but the mechanical process of eating is just blah. Then it seems to wear off faster than Tirz but it MORE than carries me to Tirz shot day. I never got nauseous or experienced any extra fatigue. My titration was not the standard, I was too scared of the anecdotals I was reading - so I went .10, .25, .25, .39, .5, and Sunday I did .67. I lost 4 lbs last week, but then none the week before? I’m not sure how much the addition of Cag is really helping me, if I can’t eat enough. I’m thinking split dosing may be in the cards for me. Tomorrow is weigh in, so we’ll see 👍
 
Mayostardayonnaise said:
I’m up to 6 mg Tirz (started July ‘25 at 2.125mg) - added Cagri 6 weeks ago, trying to stay at 6 mg longer/a 2 day bridge to shot day.
The stuff works too good, at least for me. Other people are already at 1 or 2 mg with no problems.
A real struggle to eat for 3ish days after. Not nausea at all, but the mechanical process of eating is just blah. Then it seems to wear off faster than Tirz but it MORE than carries me to Tirz shot day. I never got nauseous or experienced any extra fatigue. My titration was not the standard, I was too scared of the anecdotals I was reading - so I went .10, .25, .25, .39, .5, and Sunday I did .67. I lost 4 lbs last week, but then none the week before? I’m not sure how much the addition of Cag is really helping me, if I can’t eat enough. I’m thinking split dosing may be in the cards for me. Tomorrow is weigh in, so we’ll see 👍
Click to expand...
One on-line site recommends when adding Cag to an existing 10mg Tirz dosing schedule to use 0.6mg of Cag. I'm thinking of starting with that dose. So far, the only side-effects I've experienced with Tirz alone is fatigue.
 
I did the same thing. At tirz 10mg and added cagri. With cagri i went slow initially going from 0.25 to 0.5 to now 2.4. Initially it worked wonders especially the day after injection but the effects tapered rather quickly. So i raised the dosage until 2.4 which is where ill stay until i finish my stack. Not planning on reordering though.
 
T- 12.5mg on Sundays, Cagri (currently 1.2mg) on Wednesdays. This will be week 6. Works great, but the fatigue on week 1 and 2 was palpable. Cagri was 400mcg, 750mcg, 750mcg, 1.2mg, 1.2mg. This week will move to 1.7mg.
 
Devilseye said:
I did the same thing. At tirz 10mg and added cagri. With cagri i went slow initially going from 0.25 to 0.5 to now 2.4. Initially it worked wonders especially the day after injection but the effects tapered rather quickly. So i raised the dosage until 2.4 which is where ill stay until i finish my stack. Not planning on reordering though.
Click to expand...
Would you not reorder because the effect wears off quickly, or for what reason?
 
Mayostardayonnaise said:
I’m up to 6 mg Tirz (started July ‘25 at 2.125mg) - added Cagri 6 weeks ago, trying to stay at 6 mg longer/a 2 day bridge to shot day.
The stuff works too good, at least for me. Other people are already at 1 or 2 mg with no problems.
A real struggle to eat for 3ish days after. Not nausea at all, but the mechanical process of eating is just blah. Then it seems to wear off faster than Tirz but it MORE than carries me to Tirz shot day. I never got nauseous or experienced any extra fatigue. My titration was not the standard, I was too scared of the anecdotals I was reading - so I went .10, .25, .25, .39, .5, and Sunday I did .67. I lost 4 lbs last week, but then none the week before? I’m not sure how much the addition of Cag is really helping me, if I can’t eat enough. I’m thinking split dosing may be in the cards for me. Tomorrow is weigh in, so we’ll see 👍
Click to expand...
Yes, please keep me updated, I’m really interested. I’d also love to know whether you’re in the Bac water ONLY team, or in the team that takes the extra step of using AA because of the pH.
 
beamero said:
T- 12.5mg on Sundays, Cagri (currently 1.2mg) on Wednesdays. This will be week 6. Works great, but the fatigue on week 1 and 2 was palpable. Cagri was 400mcg, 750mcg, 750mcg, 1.2mg, 1.2mg. This week will move to 1.7mg.
Click to expand...
Has the fatigue eased by now? And can I also ask you how do you reconstitute it? Do you use just BAC water, or do you also use AA?
 
Mara_aa said:
Yes, please keep me updated, I’m really interested. I’d also love to know whether you’re in the Bac water ONLY team, or in the team that takes the extra step of using AA because of the pH.
Click to expand...
Eh, I’m on the “I’m using bac, 70% for lazy reasons and 30% for not believing it causes fibrils that would do lasting damage” team. 😅🤷‍♀️ I’m sure someone will come to tell me I’m irresponsible and I might be, there’s no way to know. My risk tolerance is really…nuanced? Lol
 
Mara_aa said:
Would you not reorder because the effect wears off quickly, or for what reason?
Click to expand...
Because after a while it feels like its doing nothing. I can take a full dose and be hungry the next morning. I can skip a dose and not feel a difference. If i take tirz for instance I can definitely feel my hunger reduced and if i skip a dose of tirz hunger gradually comes back too. So yeah, i wont reorder it because its just not that effective long term for weight loss. Short term thats a different story.
 
I added cagrilintide to tirzepatide about 8 months ago. I currently divide the doses and take each one twice a week on different days (so 4 total injections between the two peptides). I've been pretty satisfied with the results. As of yesterday I'm down 100 pounds/45 Kg over the year since I started (the first 4 months on tirzepatide alone). I was starving all the time before I added cagrilinitide. Now I sometimes forget to eat. Being diagnosed with T2D was the impetus for starting this. I'm not sure whether I'd still meet any critieria for that since my glycohemoglobin level has been well within the normal range for months. However, because of this diagnosis I use a continuous glucose monitor. Often its warning of low blood glucose is my reminder that I haven't eaten. I've recognized no adverse effects.
 
arborealtrout said:
I added cagrilintide to tirzepatide about 8 months ago. I currently divide the doses and take each one twice a week on different days (so 4 total injections between the two peptides). I've been pretty satisfied with the results. As of yesterday I'm down 100 pounds/45 Kg over the year since I started (the first 4 months on tirzepatide alone). I was starving all the time before I added cagrilinitide. Now I sometimes forget to eat. Being diagnosed with T2D was the impetus for starting this. I'm not sure whether I'd still meet any critieria for that since my glycohemoglobin level has been well within the normal range for months. However, because of this diagnosis I use a continuous glucose monitor. Often its warning of low blood glucose is my reminder that I haven't eaten. I've recognized no adverse effects.
Click to expand...
Wow! This is what I'm hoping to achieve. Can you share what your dose schedule has been for the last 4 months? Thanks!
 
I weighed 179 this morning, so 3.6 lbs lost - so the Cag definitely helped the lbs along👍 But damn! I think I’ll drop it and maybe start attempting to lower the Tirz, because I’ve only got about 20-30 lbs left to lose. I’d buy it again if needed, but not a whole kit (unless someone has a kit of 5 mg for 60 or less 🤔).
 
Mayostardayonnaise said:
Eh, I’m on the “I’m using bac, 70% for lazy reasons and 30% for not believing it causes fibrils that would do lasting damage” team. 😅🤷‍♀️ I’m sure someone will come to tell me I’m irresponsible and I might be, there’s no way to know. My risk tolerance is really…nuanced? Lol
Click to expand...
“nuanced risk tolerance” is where most of us actually sit…

I’m asking because I’m digging into cagrilintide and trying to make sense of the pH discussion beyond theory.
I’m somewhat skeptical about the fibrils (lasting damage narrative) but degradation over time is a different story.

What I’m really trying to understand is whether people who’ve used it long enough have noticed any actual drop in effectiveness over a few weeks, or if most of this is still theoretical extrapolation.
The gap between “stable for 3–4 weeks” and “2 weeks max” is pretty significant in practice.

If real-world experience points closer to 2 weeks, that changes things quite a bit for me.
Also, from a practical standpoint, having to discard a vial after just a couple of injections would be hard to justify for my use.
 
Last edited:
Mayostardayonnaise said:
I weighed 179 this morning, so 3.6 lbs lost - so the Cag definitely helped the lbs along👍 But damn! I think I’ll drop it and maybe start attempting to lower the Tirz, because I’ve only got about 20-30 lbs left to lose. I’d buy it again if needed, but not a whole kit (unless someone has a kit of 5 mg for 60 or less 🤔).
Click to expand...
I’m also looking for a 5 mg kit, just to try it out.
 
Mara_aa said:
“nuanced risk tolerance” is where most of us actually sit…

I’m asking because I’m digging into cagrilintide and trying to make sense of the pH discussion beyond theory.
I’m somewhat skeptical about the fibrils (lasting damage narrative) but degradation over time is a different story.

What I’m really trying to understand is whether people who’ve used it long enough have noticed any actual drop in effectiveness over a few weeks, or if most of this is still theoretical extrapolation.
The gap between “stable for 3–4 weeks” and “2 weeks max” is pretty significant in practice.

If real-world experience points closer to 2 weeks, that changes things quite a bit for me.
Also, from a practical standpoint, having to discard a vial after just a couple of injections would be hard to justify for my use.
Click to expand...
I don’t blame anyone being trepidatious about Cagri, I’m just ridiculous sometimes and my desire to try it overrode my fear of the fibrils deal 😬 I didn’t have AA on hand and the curiosity was too much to bear. And then I just kept using bac. My nuanced risk tolerance, admittedly, doesn’t make much sense lol. I’ve already pivoted away from things I said on here a month ago like “I think I’ll stick with only FDA approved stuff”.
 
cythehun said:
I would like to hear from those who added Cagrilintide to Tirzepatide. What was your motivation? What dosing schedule did you follow? How are the results?

Currently I am on 10mg/week of Tirzepatide. While it is mostly working well, the on-going "food noise" is sabotaging my efforts to maintain my eating discipline. Before I continuing upping my TZ dose, I would like to see if adding Cagrilintide will provide the needed appetite suppression to allow me to meet my intake goals.
Click to expand...
I had stalled and was about 10# short of my goal and my tirz was maxxed out (15mg) so I added Cagri. Slow at first and nothing but at 2.4 it helped me get restarted (did not take on the same day)

More recently I'm trying to find a maintenance level or regimen but it's been a little erratic. I sort of wait to see when the food noise comes back and then dose, usually 4 weeks? But cutting to 10mg tirz alone didn't do it. So a bit later (weeks) I went back to 15 mg tirz and 2.4mg cagri same day. Oof. I was pretty slammed. Took them on Thursday. Felt terrible by Friday and even puked early Sun AM, food I had eaten on Thursday. I didn't eat anything until Monday and not much at that. About a month before this I had a bad bout of colitis from what the MDs think was a virus so maybe my GIT was not ready for tirz/cag but I will say it worked to keep me from eating!
 
Devilseye said:
Because after a while it feels like its doing nothing. I can take a full dose and be hungry the next morning. I can skip a dose and not feel a difference. If i take tirz for instance I can definitely feel my hunger reduced and if i skip a dose of tirz hunger gradually comes back too. So yeah, i wont reorder it because its just not that effective long term for weight loss. Short term thats a different story.
Click to expand...
Got it, thanks for sharing. I was actually considering it as an add-on to tirz.
It’s a shame if it wears off that quickly.
 
arborealtrout said:
I added cagrilintide to tirzepatide about 8 months ago. I currently divide the doses and take each one twice a week on different days (so 4 total injections between the two peptides). I've been pretty satisfied with the results. As of yesterday I'm down 100 pounds/45 Kg over the year since I started (the first 4 months on tirzepatide alone). I was starving all the time before I added cagrilinitide. Now I sometimes forget to eat. Being diagnosed with T2D was the impetus for starting this. I'm not sure whether I'd still meet any critieria for that since my glycohemoglobin level has been well within the normal range for months. However, because of this diagnosis I use a continuous glucose monitor. Often its warning of low blood glucose is my reminder that I haven't eaten. I've recognized no adverse effects.
Click to expand...
Wow, that’s an incredible result, huge congrats, seriously impressive.
Really interesting to hear how well that combo worked for you. Do you reconstitute with BAC only? And if you don’t mind sharing, what doses are you running for both? And how did you introduce cagri what dose did you start with and how did you titrate up?
 
Mayostardayonnaise said:
I don’t blame anyone being trepidatious about Cagri, I’m just ridiculous sometimes and my desire to try it overrode my fear of the fibrils deal 😬 I didn’t have AA on hand and the curiosity was too much to bear. And then I just kept using bac. My nuanced risk tolerance, admittedly, doesn’t make much sense lol. I’ve already pivoted away from things I said on here a month ago like “I think I’ll stick with only FDA approved stuff”.
Click to expand...
Haha that’s quite the pivot from “only FDA-approved” to just going for it.
I guess everyone has their own risk tolerance, sometimes on completely opposite ends.
 
Calm Logic said:
Yeah, the loss in effectiveness doesn't really make sense with the CagriSema studies, including one of 68 weeks:


One study with cagri by itself :https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01751-7/abstract
Click to expand...
Yeah that’s interesting, I’ve come across similar data, so it’s a bit surprising to hear such different experiences. I guess it really varies a lot from person to person. I’m hoping I’ll be one of the lucky ones 😎
 
Wallydog said:
I had stalled and was about 10# short of my goal and my tirz was maxxed out (15mg) so I added Cagri. Slow at first and nothing but at 2.4 it helped me get restarted (did not take on the same day)

More recently I'm trying to find a maintenance level or regimen but it's been a little erratic. I sort of wait to see when the food noise comes back and then dose, usually 4 weeks? But cutting to 10mg tirz alone didn't do it. So a bit later (weeks) I went back to 15 mg tirz and 2.4mg cagri same day. Oof. I was pretty slammed. Took them on Thursday. Felt terrible by Friday and even puked early Sun AM, food I had eaten on Thursday. I didn't eat anything until Monday and not much at that. About a month before this I had a bad bout of colitis from what the MDs think was a virus so maybe my GIT was not ready for tirz/cag but I will say it worked to keep me from eating!
Click to expand...
Omg that reaction sounds really rough. Definitely shows how strong that combo can be.
When you were breaking the stall, were you doing one weekly injection of tirz and one of cagri?
 
I do about 11 mg of tirz every 5 days. I had hunger creeping back in so I tried Cagri. .25 did nothing but when I tried .50 it was like that first good dose of Tirz again. I didn’t want anything to do with food. I now just use it when I’m feeling stress hunger creeping back in. So I take more of an “as needed” approach with it. Haven’t had a shot of it in a couple months the but it’s nice to know it’s there whenever I get hunger ramping back up.
 
How do you store it n betwen? Do you reconstitute a new vial every time? Do you freeze it in between uses? TIA.
 
Chunkomatic said:
I do about 11 mg of tirz every 5 days. I had hunger creeping back in so I tried Cagri. .25 did nothing but when I tried .50 it was like that first good dose of Tirz again. I didn’t want anything to do with food. I now just use it when I’m feeling stress hunger creeping back in. So I take more of an “as needed” approach with it. Haven’t had a shot of it in a couple months the but it’s nice to know it’s there whenever I get hunger ramping back up.
Click to expand...
I like this approach. How long did it take after you went up to .50 on Cag to feel the effect?
Also, when you take it "as needed" do you stay at the .50 dose? How long after you take the "as needed" dose do you feel the effect?
 
You must log in or register to reply here.

Trending Topics

Latest Posts

Forum Statistics

Threads
18,623
Posts
194,026
Members
62,180
Newest
Mochiato
Back
Top Bottom