octopusthorpe
GLP-1 Apprentice
I'm starting week 9 of reta and have lost 23.8lb in that time, much to my utter surprise.
My question is - I'm seeing most people are on weekly doses of anywhere between 2mg up to 10mg and having similar success, but is there anyone who has seen the same success on 1mg/week (or lower)? I've heard the term "hyper responder" thrown around quite a bit, but it sounded like some kind of urban legend.
To better illustrate, I did the nerd thing and made a graph showing weight vs bi-weekly reta dose (below).
I started at 0.5mg 2x/week to mitigate sides, and had so much success at that dose I stayed there until the end of March. Titrated up to 0.7mg for a couple weeks, more out of experimentation than necessity, and started to feel like absolute dogsh*t (fatigue, poor performance in the gym, hiking endurance tanked.)
I dose on Tuesday mornings and Friday evenings, and am feeling so much better today after Friday's lower (0.5mg) dose.
On reta, I've had no appreciable impacts to my RHR (I'm usually anywhere between 46-48 BPM, on reta it hovers around 49-50 BPM), sleep (getting between 7-8 hours per night, average sleep score 80), HRV is balanced, all of which I honestly thought was odd considering the anecdotes I've read. But I'll take it 🙂
Some things to note:
1) Female, 50 years old, 5'10.5"
2) I have never been on a GLP prior to reta
3) I lost 160lb back in 2016 via a low-carb, high protein diet (usually 1-1.2g per pound of lean mass)
4) I have been powerlifting since 2017 as well as long-distance hiking, so I had a significant amount of muscle mass and endurance coming into this
5) My weight started creeping up in late 2024 on account of perimenopause, so I was about 25-30lb heavier than my lowest in 2016
6) My diet is still relatively low carb (getting more protein in on reta, usually 175g/day) though I do use easily digestible carbs pre-workout
7) I strength train 4-5x per week, moderate cardio (indoor bike) 3-4x per week, and one long-distance hike (anywhere from 20-30 miles) most Saturdays. I don't track steps or do the whole "10k steps per day" thing as I prefer mileage (when you have stupid long legs and a 41" stride length, tracking steps is somewhat annoying)
8) I am on estradiol - 0.0375 patch 2/weekly, and test-c 10mg weekly split into 2 doses for perimenopause
I also want to add I'm glad this forum exists - have you seen the reta subreddit? Holy hell that place is a dumpster fire of stupidity. It's actually kind of impressive. 🤣
My question is - I'm seeing most people are on weekly doses of anywhere between 2mg up to 10mg and having similar success, but is there anyone who has seen the same success on 1mg/week (or lower)? I've heard the term "hyper responder" thrown around quite a bit, but it sounded like some kind of urban legend.
To better illustrate, I did the nerd thing and made a graph showing weight vs bi-weekly reta dose (below).
I started at 0.5mg 2x/week to mitigate sides, and had so much success at that dose I stayed there until the end of March. Titrated up to 0.7mg for a couple weeks, more out of experimentation than necessity, and started to feel like absolute dogsh*t (fatigue, poor performance in the gym, hiking endurance tanked.)
I dose on Tuesday mornings and Friday evenings, and am feeling so much better today after Friday's lower (0.5mg) dose.
On reta, I've had no appreciable impacts to my RHR (I'm usually anywhere between 46-48 BPM, on reta it hovers around 49-50 BPM), sleep (getting between 7-8 hours per night, average sleep score 80), HRV is balanced, all of which I honestly thought was odd considering the anecdotes I've read. But I'll take it 🙂
Some things to note:
1) Female, 50 years old, 5'10.5"
2) I have never been on a GLP prior to reta
3) I lost 160lb back in 2016 via a low-carb, high protein diet (usually 1-1.2g per pound of lean mass)
4) I have been powerlifting since 2017 as well as long-distance hiking, so I had a significant amount of muscle mass and endurance coming into this
5) My weight started creeping up in late 2024 on account of perimenopause, so I was about 25-30lb heavier than my lowest in 2016
6) My diet is still relatively low carb (getting more protein in on reta, usually 175g/day) though I do use easily digestible carbs pre-workout
7) I strength train 4-5x per week, moderate cardio (indoor bike) 3-4x per week, and one long-distance hike (anywhere from 20-30 miles) most Saturdays. I don't track steps or do the whole "10k steps per day" thing as I prefer mileage (when you have stupid long legs and a 41" stride length, tracking steps is somewhat annoying)
8) I am on estradiol - 0.0375 patch 2/weekly, and test-c 10mg weekly split into 2 doses for perimenopause
I also want to add I'm glad this forum exists - have you seen the reta subreddit? Holy hell that place is a dumpster fire of stupidity. It's actually kind of impressive. 🤣
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