New Reta Triumph 1 Results
- Thread starter m100568
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FarmgirlRebel
GLP-1 Enthusiast
Interesting.
While at 80 weeks there is a clear difference between 4mg and 12mg for weight loss.
But pull back to to 104 weeks out, those differences are pretty much insignificant, esp between 4mg and 9mg.
While at 80 weeks there is a clear difference between 4mg and 12mg for weight loss.
But pull back to to 104 weeks out, those differences are pretty much insignificant, esp between 4mg and 9mg.
PinKushn
GLP-1 Apprentice
And how does the placebo group jump to from 2% to 19%??
Because all participants titrated up to their maximum tolerated dose of reta from weeks 80-104 according to the chart and study design.
Some comments from a blogger who participated in the trial.
alphaamigo
GLP-1 Apprentice
I really like that this suggests that those who seemed to reach their maximum potential weight loss at 4mgs were able to titrate up in the last 24 weeks and nearly catch up to the highest dose.
woundcarping
GLP-1 Specialist
I'm right there with the poster. I've lost 27.5% in 8 months. The last 12 lbs took 2 months. Your set point fights the last bit of loss hard.
mybodyisasewer
GLP-1 Apprentice
This is a national security issue.
The US DoD needs to make sure gen Z has this stuff so they're fit for service.
The CCP is selling us the drugs that will improve the draft pool of their adversary.
For some reason the US is ok with keeping their kids fat, and the Chinese are ok with making them fit.
This confuses the patriot.
The US DoD needs to make sure gen Z has this stuff so they're fit for service.
The CCP is selling us the drugs that will improve the draft pool of their adversary.
For some reason the US is ok with keeping their kids fat, and the Chinese are ok with making them fit.
This confuses the patriot.
Thanks for posting. It's really amazing that the placebo group lost 17% (19.2% - 2.2% at week 80) of their body weight from week 80 to 104 (just 24 weeks). The 4mg group only lost 19% over 80 weeks (that's over a year more than the placebo group). Clearly the placebo group titrated up quickly and lost weight quickly and matched the total weight loss of the 4mg over 2 years. That's freaking amazing.
I would love to know if they gave some MEGA-LAXATIVE as placebo
Another HUGE takeaway from the phase 3 top line results is that even starting at week 80, that titrating up can produce additional weight loss up to week 104 (2 years) Freaking YEAH! The effect was more so for the 4mg folks rather than the 9mg folks as we would expect. But even for the 9mg folks, titrating up at week 80 to week 104 produced almost an additional 3.4% of loss.
25MG of Tirzepatide, here I come, clear the way 😂. I’d gladly take 3.4% more weight loss right about now….
25MG of Tirzepatide, here I come, clear the way 😂. I’d gladly take 3.4% more weight loss right about now….
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More for them to kill/
🙄 🙄 🙄 though, the placebo details seem very sketchy to me.
Yes, the 17% in 24 weeks seems pretty dramatic. But by week 80, those people were so desperate to lose weight that they went on a hunger strike 😂.
It seems more like in their desperation, they stole a bunch of Reta vials and went on a stabbing spree.
woundcarping
GLP-1 Specialist
You realize the placebo group got put on Reta after 80 weeks and that caused them to lose weight, right?
Didn’t the 12mg group lose 24% in 48 weeks on another trial?
FarmgirlRebel
GLP-1 Enthusiast
I know...weird. Placebo certainly is a real effect.
That's why it seemed sketchy to me, meaning the study methodology. How can you call them a placebo group when they were given the real deal? Second, some indicate they were given the drug later on and then they got huge weight loss...All of that seemed off to me.
woundcarping
GLP-1 Specialist
The placebo group is the control group… everyone is in the control group until the test variable is introduced…. For the ones that started getting Reta at 80 weeks, they were in the control group before that. Picture it as consecutive trials with the control groups running concurrently for the placebo and lower dose escalation trials.
Right, that's how I saw it, too. IMO, that methodology seems flawed to me because the moment we give the real drug to a group, how can they be called placebo group after that? Also, doesn't that defeat the whole purpose of a placebo group in the first place? IMO, if we want to test the efficacy of a drug over long-slow-titration, quick-dose-escalation, and a real placebo group, shouldn't we keep a third group who never gets the drug? Do you get my assertion?
Bioexplorer
GLP-1 Apprentice
The real question is why did the participants remain in the trial after it became obvious they were in the placebo group? Apparently the monetary incentive was adequate to keep them ethical.
I told my brother about the Reta trials enrolling and he immediately looked into it. Fortunately, he didn't qualify since he previously was on tirz. He's the kind of participant nobody wants in their trial. He is familiar with GLP-1 effects and told me he would drop out in the first week if he didn't feel any effects.🤷
I told my brother about the Reta trials enrolling and he immediately looked into it. Fortunately, he didn't qualify since he previously was on tirz. He's the kind of participant nobody wants in their trial. He is familiar with GLP-1 effects and told me he would drop out in the first week if he didn't feel any effects.🤷
Airborne Daddy
GLP-1 Specialist
Better yet how did placebo group at 104 weeks post numbers not too far off from the 4mg reta group....
Yeah, that's hard to believe because the 4mg was on reta for 80 weeks and the placebo on nothing for those 80 weeks and then both groups titrated up to the maximum tolerated dose. That doesn't speak well for staying on lose doses for long periods of time.
alphaamigo
GLP-1 Apprentice
You get paid to participate in a medical trial whether you are on the real deal or a placebo. When I did medical trial, it was $1000/wk for the 8 weeks. (Not a weight loss trial)
chewonmysac
GLP-1 Enthusiast
The side effects profile was much more pronounced in higher dosages. If anything, these results just reaffirmed my choice to stick with Tirzepatide, as my personal results have exceeded the Reta trial results without any of the side effects. Down 35.4% total weight in 52 weeks.
BNLFL
GLP-1 Specialist
I've had none of these, and I'm on 8mg.
mybodyisasewer
GLP-1 Apprentice
Sometimes I wonder how different my opinion would be if I had tried tirz instead of reta when I first got into this.
But I tried reta. So it's the best one. And your opinion is wrong.
SVT810E
GLP-1 Novice
🚫No Source Discussion🚫
It was an extension, not part of the main trial. The main trial ended with the placebo group still injecting sterile water. Only after that did they get switched.
