GLP-1 Resistance Has a Name Now: A Gene Called PAM

[RetCurious]

She did everything right.

A 38-year-old teacher, newly diagnosed with type 2 diabetes, starts a GLP-1 drug in the winter. She injects on the same morning every week. She keeps the food log. She walks after dinner. Six months later her A1c has barely moved, and her endocrinologist is gently asking whether she has been taking it as prescribed.

She has. The drug is doing what it does for almost everyone. It is just not doing it for her. And until this spring, nobody in that exam room could have told her why.

https://archive.is/0XyQ9

 

[headward]

Wonder if elora will fix these issues. I don't think it is classified as a glp.

 

[joseblo]

Wonder if elora will fix these issues. I don't think it is classified as a glp.

It and Cagri are amylin receptor agonists, so yes completely different. Don't have all the same benefits, but if all you're looking for is reducing hunger, they do that.

 

[Grogu]

She did everything right.

A 38-year-old teacher, newly diagnosed with type 2 diabetes, starts a GLP-1 drug in the winter. She injects on the same morning every week. She keeps the food log. She walks after dinner. Six months later her A1c has barely moved, and her endocrinologist is gently asking whether she has been taking it as prescribed.

She has. The drug is doing what it does for almost everyone. It is just not doing it for her. And until this spring, nobody in that exam room could have told her why.

https://archive.is/0XyQ9

Thanks for sharing. Good to know that there is some explaination for some of the significant number non-responders to these medications. It’s partly PAM’s fault going forward.

 

[RetCurious]

We're going to have to quit inviting PAM to the party.

 

[miameow]

I feel vindicated. It was PAM, all along, not me.

 

[TooGood76]

Wonder if elora will fix these issues. I don't think it is classified as a glp.

Reta and Tirz both hit receptors other receptors in addition to GLP1 but yes Cagri and Elora are amilyn receptors without a GLP component at all

 

[TooGood76]

We're going to have to quit inviting PAM to the party.

 

[Chili777]

I dated a girl named PAM once. She was very resistant, too. Sorry, couldn't resist.