Metabolic effect of reta

[jusmypullup]

So, i've been on reta for about 2 weeks now (3mg both weeks) and am curious at what stage of side effects that the BMR increase is most prevalent at. I get some appetite suppresion but am still hungry most of the time so I'm thinking about titrating up but am not sure yet. I'm cool with food noise as long as I'm getting roughly the maximum effect of the reta in the metabolic realm of it.

 

[woundcarping]

It seems a safe assumption that it’s dose dependent with diminishing returns.

 

[lessthanhalf]

I just had a look at this, apparently no one has ever actually measured energy expenditure on reta in humans, so pretty much everything written on the subject is guesswork or maybe extrapolation from animal studies. ( but mice and rats regulate temperature very differently to humans )
The usual numbers are 100-200 kcal/day at 12mg, and most likely it is dose dependent, but these numbers are not actually based on human measurements so not exactly reliable.
So for maximum metabolic effect , maximum dose, but all guesswork really.
If reta causes 100 kcal/day of extra EE then that would correspond to about 5% or 5kg extra weight loss over a year, which is close to the extra weight loss that it causes compared to tirz, assuming they reduce food intake the same amount, and both at their max doses.

 

[jpru2001]

I just had a look at this, apparently no one has ever actually measured energy expenditure on reta in humans, so pretty much everything written on the subject is guesswork or maybe extrapolation from animal studies. ( but mice and rats regulate temperature very differently to humans )
The usual numbers are 100-200 kcal/day at 12mg, and most likely it is dose dependent, but these numbers are not actually based on human measurements so not exactly reliable.
So for maximum metabolic effect , maximum dose, but all guesswork really.
If reta causes 100 kcal/day of extra EE then that would correspond to about 5% or 5kg extra weight loss over a year, which is close to the extra weight loss that it causes compared to tirz, assuming they reduce food intake the same amount, and both at their max doses.

Yeah out of curiosity I looked at the studies, did some math, and came to the same conclusion its 100-200/day depending on dose and size of the person. Plus have seen this math elsewhere and it makes sense. Anecdotally, so far for my lab rat at 9 weeks or so the calories in/calories out math is also coming out to be somewhere in that range of missing calories I can't explain.

Doing the same thing I have done the old fashioned way to lose 1.5 lbs/week and I am losing 1.8 lbs/week. 0.3 lbs x 3500 calories = 1050 calories/7 days = 150 cal/day. Have not changed my workout routine either.

Obviously 9 weeks with a single person is not a great sample size, but hey it lines up.