Anyone gone above 15mg on tirzepatide?

[6friedeggs]

Anyone gone above 15mg on tirzepatide?
I'm currently on 15mg and thinking about going up, or maybe even adding some cagrilintide to aid with appetite suppresion

 

[Skidude]

I have seen people post about current trials and quite a few members have stated they are upwards of 25-30mg
I personally have been on 15mg for quite a while but am not going up as I am at goal.

here is more info on current trials:

The standard FDA-approved maintenance doses for tirzepatide (Mounjaro and Zepbound) cap at 15 mg weekly. Clinical trials directly investigating the 25 mg dose as a higher-tier option (alongside a 20 mg dose) are actively ongoing to evaluate its efficacy and safety for slower responders. [1, 2, 3]

Key Details on the 25 mg Tirzepatide Clinical Trial

• Clinical Trial ID: NCT06037252
• Sponsor: Eli Lilly and Company
• Target Audience: Adults living with both obesity and Type 2 diabetes.
• Study Goal: The trial is designed specifically to test the safety, tolerability, and efficacy of investigational, higher doses (20 mg and 25 mg). It aims to determine if escalating to these levels provides enhanced glycemic control and accelerated weight loss for patients who see limited results from the 15 mg maximum. [1, 2, 3, 4]

 

[eidos]

Yes, I saw a case like that in a report from the Calgary emergency department.

A few days ago, U.S. health authorities reported 18,000 cases of overdose, many of which involved people who injected multiple doses or even the entire contents of the pen.

If Tirz doesn't work at 15 mg, try Reta, and if that still doesn't work, it means you're among the 10-20% of people who have receptor mutations.

 

[chewonmysac]

The T100 is waiting for you. It is your Destiny.
Or
Add Eloralintide.

 

[Summer48]

I have taken 20 and 22 mg felt no different to 15mg but a few weeks ago took 30mg by mistake and felt dreadful for 2 days. All times didn’t lose anymore weight than usual

 

[Sasquatch]

Anyone gone above 15mg on tirzepatide?
I'm currently on 15mg and thinking about going up, or maybe even adding some cagrilintide to aid with appetite suppresion

Yes, I've done 20/19.5mg tirz. for over a month. Up from 15mg.
I don't know what you're trying to achieve, but it's nauseating to eat virtually anything. I got used to it. I wouldn't recommend it. The peptide is for obese people to tolerate a caloric deficit. Read the indications. It slows gastric emptying. A glp and g1p agonist. People think it's like speed. The more, the better. No. These are for assisting a caloric deficit program. The closer one gets to goal, the trickier the game gets. Of 16 months 9-10 months were essentially too easy. Many are finding this. Sorry for the ramble

 

[Gr33dyOctopus]

Yes, I've done 20/19.5mg tirz. for over a month. Up from 15mg.
I don't know what you're trying to achieve, but it's nauseating to eat virtually anything. I got used to it. I wouldn't recommend it. The peptide is for obese people to tolerate a caloric deficit. Read the indications. It slows gastric emptying. A glp and g1p agonist. People think it's like speed. The more, the better. No. These are for assisting a caloric deficit program. The closer one gets to goal, the trickier the game gets. Of 16 months 9-10 months were essentially too easy. Many are finding this. Sorry for the ramble

Yes 10 months to easy and now its suddenly tougher and not working like it did.

 

[JuneBug1956]

I have done 10 mg every 5 days for a few months without problems. Best appetite suppression is when I added a bit of Sema a few days after the Tirz. Also Cagri works for that too. I have been on all 3 at times chasing appetite suppression. They all got me to goal. Good luck.

 

[woundcarping]

I have taken 20 and 22 mg felt no different to 15mg but a few weeks ago took 30mg by mistake and felt dreadful for 2 days. All times didn’t lose anymore weight than usual

Didn’t lose more weight than usual, or you were stalled and didn’t lose more weight?

I realize both could be true, but “more weight than usual” implies you were losing weight anyways.

 

[spanky2026]

I have no problem with the idea of going past 15 if I need to, thankfully not there yet. Anyone know an ETA on when these studies might be released?

 

[Skidude]

I have no problem with the idea of going past 15 if I need to, thankfully not there yet. Anyone know an ETA on when these studies might be released?

If I understand it looks like Fall of this year?

https://clinicaltrials.gov/study/NCT06037252#study-plan

 

[eternalyouth2]

I have done 10 mg every 5 days for a few months without problems. Best appetite suppression is when I added a bit of Sema a few days after the Tirz. Also Cagri works for that too. I have been on all 3 at times chasing appetite suppression. They all got me to goal. Good luck.

Curious as how much sema you added? Would you mind sharing more? Currently at 15mg weekly of T but it’s not working like it used to. I have some sema and I’m inclined to add it to my rotation. Thanks!

 

[lessthanhalf]

I have seen people post about current trials and quite a few members have stated they are upwards of 25-30mg
I personally have been on 15mg for quite a while but am not going up as I am at goal.

here is more info on current trials:

The standard FDA-approved maintenance doses for tirzepatide (Mounjaro and Zepbound) cap at 15 mg weekly. Clinical trials directly investigating the 25 mg dose as a higher-tier option (alongside a 20 mg dose) are actively ongoing to evaluate its efficacy and safety for slower responders. [1, 2, 3]

Key Details on the 25 mg Tirzepatide Clinical Trial

• Clinical Trial ID: NCT06037252
• Sponsor: Eli Lilly and Company
• Target Audience: Adults living with both obesity and Type 2 diabetes.
• Study Goal: The trial is designed specifically to test the safety, tolerability, and efficacy of investigational, higher doses (20 mg and 25 mg). It aims to determine if escalating to these levels provides enhanced glycemic control and accelerated weight loss for patients who see limited results from the 15 mg maximum. [1, 2, 3, 4]

I looked quite thoroughly through all those reference links to find the source of the doses you mentioned, as I have previously searched for this information and could not find it. The only reference I could find about doses was from OTP a blog that mentioned "sources", saying those were the doses, which may well be correct as it makes sense that they would study 20-25mg, but is not a definitive source, like from lily or a paper or a trial. The trial info very explicitly does not include any info on doses used.

 

[Skidude]

I looked quite thoroughly through all those reference links to find the source of the doses you mentioned, as I have previously searched for this information and could not find it. The only reference I could find about doses was from OTP a blog that mentioned "sources", saying those were the doses, which may well be correct as it makes sense that they would study 20-25mg, but is not a definitive source, like from lily or a paper or a trial. The trial info very explicitly does not include any info on doses used.

This is what lead me to the trial:

Eli Lilly is conducting Phase 2 clinical trials testing investigational, higher doses of tirzepatide (the active ingredient in Zepbound and Mounjaro). The highest FDA-approved dosage is currently 15 mg, but ongoing studies (ClinicalTrials.gov identifier NCT06037252) are evaluating the safety and efficacy of previously unexplored, higher doses. [1, 2, 3, 4]

Why Higher Doses Are Being Studied

• Target Audience: The trials focus on adults with Type 2 diabetes and obesity who are already on metformin.
• Enhanced Efficacy: These studies aim to see if higher doses can provide deeper glycemic control and accelerate weight loss for patients who do not respond fully to current dosages.
• Trial Timeline: The Phase 2 study officially concludes in October. [1, 2, 3]

 

[Super Trips]

15mg is breakfast dose of tirz for me

 

[CJsMom]

I looked quite thoroughly through all those reference links to find the source of the doses you mentioned, as I have previously searched for this information and could not find it. The only reference I could find about doses was from OTP a blog that mentioned "sources", saying those were the doses, which may well be correct as it makes sense that they would study 20-25mg, but is not a definitive source, like from lily or a paper or a trial. The trial info very explicitly does not include any info on doses used.

I think I read somewhere that they had applied for patents for 20mg and 25 mg doses. Gemini says this, but I haven't checked the references. Hallucinations are a thing.

Yes, Eli Lilly has filed patent applications specifically targeting higher doses and concentrations of tirzepatide (the active ingredient in Mounjaro and Zepbound).

The primary international patent application addressing this is WO2024006662A1 (titled "Tirzepatide Compositions and Use"), which was published in early 2024.

Key details from the patent filings reveal how Eli Lilly is preparing for higher-dose formulations:

• Increased Concentration: While the current maximum approved dose of tirzepatide is 15 mg (delivered in a 0.5 mL injection, which equals a concentration of 30 mg/mL), the patent application explicitly claims stable, pharmaceutically acceptable compositions containing greater than 30 mg/mL, and up to 60 mg/mL of tirzepatide.
• Specific Dosing Strengths: The filing specifically details formulation concentrations of 40 mg/mL, 50 mg/mL, 55 mg/mL, and 60 mg/mL. In the standard 0.5 mL injection volume, a 40 mg/mL to 60 mg/mL concentration would translate to higher total doses, such as 20 mg, 25 mg, or 30 mg.
• Stated Purpose: The patent application notes that a significant number of patients require "additional weight management benefit" beyond the currently approved 15 mg maximum. It focuses on the chemical stability needed to keep these denser peptide concentrations shelf-stable for at least 6 months while managing the gastrointestinal side effects associated with higher doses.

By securing these patents, Eli Lilly is laying the legal and regulatory groundwork to eventually introduce stronger versions of Mounjaro and Zepbound if clinical trials show that higher doses provide superior weight loss or glycemic control with acceptable safety profiles.

 

[Super Trips]

I think I read somewhere that they had applied for patents for 20mg and 25 mg doses. Gemini says this, but I haven't checked the references. Hallucinations are a thing.

Yes, Eli Lilly has filed patent applications specifically targeting higher doses and concentrations of tirzepatide (the active ingredient in Mounjaro and Zepbound).

The primary international patent application addressing this is WO2024006662A1 (titled "Tirzepatide Compositions and Use"), which was published in early 2024.

Key details from the patent filings reveal how Eli Lilly is preparing for higher-dose formulations:

• Increased Concentration: While the current maximum approved dose of tirzepatide is 15 mg (delivered in a 0.5 mL injection, which equals a concentration of 30 mg/mL), the patent application explicitly claims stable, pharmaceutically acceptable compositions containing greater than 30 mg/mL, and up to 60 mg/mL of tirzepatide.
• Specific Dosing Strengths: The filing specifically details formulation concentrations of 40 mg/mL, 50 mg/mL, 55 mg/mL, and 60 mg/mL. In the standard 0.5 mL injection volume, a 40 mg/mL to 60 mg/mL concentration would translate to higher total doses, such as 20 mg, 25 mg, or 30 mg.
• Stated Purpose: The patent application notes that a significant number of patients require "additional weight management benefit" beyond the currently approved 15 mg maximum. It focuses on the chemical stability needed to keep these denser peptide concentrations shelf-stable for at least 6 months while managing the gastrointestinal side effects associated with higher doses.

By securing these patents, Eli Lilly is laying the legal and regulatory groundwork to eventually introduce stronger versions of Mounjaro and Zepbound if clinical trials show that higher doses provide superior weight loss or glycemic control with acceptable safety profiles.

60mg lets goooooooooo

 

[lessthanhalf]

I think I read somewhere that they had applied for patents for 20mg and 25 mg doses. Gemini says this, but I haven't checked the references. Hallucinations are a thing.

Yes, Eli Lilly has filed patent applications specifically targeting higher doses and concentrations of tirzepatide (the active ingredient in Mounjaro and Zepbound).

The primary international patent application addressing this is WO2024006662A1 (titled "Tirzepatide Compositions and Use"), which was published in early 2024.

Key details from the patent filings reveal how Eli Lilly is preparing for higher-dose formulations:

• Increased Concentration: While the current maximum approved dose of tirzepatide is 15 mg (delivered in a 0.5 mL injection, which equals a concentration of 30 mg/mL), the patent application explicitly claims stable, pharmaceutically acceptable compositions containing greater than 30 mg/mL, and up to 60 mg/mL of tirzepatide.
• Specific Dosing Strengths: The filing specifically details formulation concentrations of 40 mg/mL, 50 mg/mL, 55 mg/mL, and 60 mg/mL. In the standard 0.5 mL injection volume, a 40 mg/mL to 60 mg/mL concentration would translate to higher total doses, such as 20 mg, 25 mg, or 30 mg.
• Stated Purpose: The patent application notes that a significant number of patients require "additional weight management benefit" beyond the currently approved 15 mg maximum. It focuses on the chemical stability needed to keep these denser peptide concentrations shelf-stable for at least 6 months while managing the gastrointestinal side effects associated with higher doses.

By securing these patents, Eli Lilly is laying the legal and regulatory groundwork to eventually introduce stronger versions of Mounjaro and Zepbound if clinical trials show that higher doses provide superior weight loss or glycemic control with acceptable safety profiles.

Thanks for that, it is something I have been curious about but obviously my research was much less thorough than yours and I did not think to look up patent info. It is pretty convincing evidence that they are at least considering doses up to 30mg, and the closest thing I have seen to definitive info about it.

And it makes sense, those doses . I was surprised that with the high dose semaglutide studies , they went so high in doses, either 7.2mg or 16mg, and not that surprised with the results, a bit of extra weight loss, with a lot of extra side effects. But even an extra 5% weight loss with higher dose tirz could be useful to those with a lot of weight to lose or who lose less than average amounts, assuming side effects are not too bad.

What would be really interesting and useful is a trial of higher doses in non responders or weak responders, especially those who had minimal side effects at full doses, to see if it helps or not, as there are at least 5-10% who respond poorly.