Transition from 15mg Tirz to Tirz+Reta dosage questions for obese male

[TropicalBlaster]

Hi all,

Male 34 | 5'10
History: Obease my whole life as a result of incorrect medical information from dietitians. Was brought up on 'low fat' from the age of 3, so my whole diet was basically just sugar until I was in my 20s. I probably didn't start eating properly until 25YO.
[Max weight 155 kg (342 lbs) DEC 2019]

Starting weight 136 kg (300 lbs) JAN 2025
Current weight 110 kg (242 lbs) JUN 2026
Goal weight 90 kg (198 lbs) DEC 2026

Currently I'm on 15 mg/week TIRZ and I still have food noise/ cravings. I've recently gone onto a carnivore diet as this has helped with food noise in the past. My plan is to keep on Carnivore until I get below 100 kg and then transition to a calorie deficit.

I've ordered RETA to supplement, but wondering how much to drop TIRZ....
My Plan is to inject 2x/week (TIRZ on Sunday, RETA on Wednesday)

• 12.5 mg TIRZ and 2mg RETA for 4 weeks; then,
• 10 mg TIRZ and 4mg RETA for 4 weeks; then,
• 7.5mg TIRZ and 6mg RETA until goal weight.

Does anyone have any experience or advice on the above?
P.S. I've also got GHK-CU on order which I'm planning to do 2mg/day.

Edit: spelling

 

[indolent]

Currently I'm on 15 mg/week TIRZ and I still have food noise/ cravings.

Is there a pattern to that (e.g. it hits in the last day or two before pin day)? If so (and maybe even if not), your first tactic should be split-dosing (every 3.5 days at half the dose each time) or an alternative dosing schedule like every 5 days at a reduced amount (play around with https://glp1plotter.com )

Everyone's different, but for most/many retatrutide is much less good at appetite suppression than tirz. It works in more mysterious ways, but it sounds like you want strong suppression at a minimum. If you're not having intolerable constipation from tirzepatide, cagrilintide might be your best move after split-dosing. Read up thoroughly on it ... a tiny bit has huge effects and side effects, and a tiny bit more massively unpleasant, so titrate particularly slowly.

Then maybe a little retatrutide later, but not as a main driver.

 

[Jrammi]

If I may suggest, you should improve insulin resistance by going into and staying in ketosis by cutting out carbs, including fruits. A ketomojo meter will tell you exactly the level of ketosis that you are in. We are not designed to eat three meals a day, and sugar and other high glycemic foods are addictive like drugs. Intermittent and long-term fasting (with electrolytes) has tremendous health benefits. It's also important to log everything you eat to remain in a calorie deficit.

 

[finesse]

I just started stacking reta with triz. I'm really hungry. Im eating slightly more, but weight is moving the right way. My suggestion would be to keep your triz dose the same.

 

[Calm Logic]

If I may suggest, you should improve insulin resistance by going into and staying in ketosis by cutting out carbs, including fruits. A ketomojo meter will tell you exactly the level of ketosis that you are in. We are not designed to eat three meals a day, and sugar and other high glycemic foods are addictive like drugs.

Or do the exact opposite and do a starch-based diet.

In any case, I love reta. It does the best for weight loss, even two years later in the studies. Maybe tirz + elora will beat reta in the studies, but maybe not.

Personally, I would slowly transition to reta (by itself, as a monotherapy for a while), stacking tirz and reta in the meantime, like what you were showing above. Then add cagri or elora to reta, if needing additional assistance on 8+ mg of reta.

 

[Jrammi]

Or do the exact opposite and do a starch-based diet.

In any case, I love reta. It does the best for weight loss, even two years later in the studies. Maybe tirz + elora will beat reta in the studies, but maybe not.

Personally, I would slowly transition to reta (by itself, as a monotherapy for a while), stacking tirz and reta in the meantime, like what you were showing above. Then add cagri or elora to reta, if needing additional assistance on 8+ mg of reta.

And now comes the Vegan....

 

[Poppilapew]

I am also on 15mg triz once a week, interested to see how this goes for you! Good luck!!

 

[RubbaDubba1]

Are you still losing weight on the 15mg dose and are you diabetic? Are you willing to take a slightly higher dose of Tirz?

I ask cuz, I have family that was topped out at 15mg of Turz and sugars and weight were headed in the wrong direction for some time. Short story, I pointed her in the grey market direction (after she verbally berated me about it) and she started adding 1mg of Tirz a day after her 15mg shot. Took 6 weeks, but it got her back on the right track. I don't know, if this is the best solution for her, but it's working for now and she can always dose up. She eats really clean, cooks and walks a ton. With her diabetes and autoimmune, I didn't want to recommend Reta. Didn't know if this is something you considered?

I'm not against what you're doing, I've done it myself (non diabetic) and it worked really well for me. I started at 7.5mg Tirz and 0.5mg Reta and over 3 months ended up at 4mg of just Reta and lost 23lbs the last month. It's worx really well for some, I would slow roll it at 1mg to start for a couple weeks, then titrate up slowly from there. Just so you know how you will react to it 1st.

 

[ColdSmoke]

I would just go up to 17.5mg Tirz. Then stay there and add .5 or 1mg of Reta slowly upping that without dropping the Tirz.

 

[gusterbuster]

Maybe evaluate diet. Carnivore without glp should be hard to eat enough to maintain your weight. Are you tracking what you eat. Feel like some carnivores go overboard with butter and cream.

And man, reta makes me crave sugar and starch and couldnt do low carb/ Carnivore on it. Shit used to multi day fast and now it requires me to eat small frequent meals

 

[Jrammi]

Maybe evaluate diet. Carnivore without glp should be hard to eat enough to maintain your weight. Are you tracking what you eat. Feel like some carnivores go overboard with butter and cream.

And man, reta makes me crave sugar and starch and couldnt do low carb/ Carnivore on it. Shit used to multi day fast and now it requires me to eat small frequent meals

For me, adding HGH made me hungry even while on Tirz. That and weed...