Transition from 15mg Tirz to Tirz+Reta dosage questions for obese male

[TropicalBlaster]

Hi all,

Male 34 | 5'10
History: Obease my whole life as a result of incorrect medical information from dietitians. Was brought up on 'low fat' from the age of 3, so my whole diet was basically just sugar until I was in my 20s. I probably didn't start eating properly until 25YO.
[Max weight 155 kg (342 lbs) DEC 2019]

Starting weight 136 kg (300 lbs) JAN 2025
Current weight 110 kg (242 lbs) JUN 2026
Goal weight 90 kg (198 lbs) DEC 2026

Currently I'm on 15 mg/week TIRZ and I still have food noise/ cravings. I've recently gone onto a carnivore diet as this has helped with food noise in the past. My plan is to keep on Carnivore until I get below 100 kg and then transition to a calorie deficit.

I've ordered RETA to supplement, but wondering how much to drop TIRZ....
My Plan is to inject 2x/week (TIRZ on Sunday, RETA on Wednesday)

• 12.5 mg TIRZ and 2mg RETA for 4 weeks; then,
• 10 mg TIRZ and 4mg RETA for 4 weeks; then,
• 7.5mg TIRZ and 6mg RETA until goal weight.

Does anyone have any experience or advice on the above?
P.S. I've also got GHK-CU on order which I'm planning to do 2mg/day.

Edit: spelling

 

[indolent]

Currently I'm on 15 mg/week TIRZ and I still have food noise/ cravings.

Is there a pattern to that (e.g. it hits in the last day or two before pin day)? If so (and maybe even if not), your first tactic should be split-dosing (every 3.5 days at half the dose each time) or an alternative dosing schedule like every 5 days at a reduced amount (play around with https://glp1plotter.com )

Everyone's different, but for most/many retatrutide is much less good at appetite suppression than tirz. It works in more mysterious ways, but it sounds like you want strong suppression at a minimum. If you're not having intolerable constipation from tirzepatide, cagrilintide might be your best move after split-dosing. Read up thoroughly on it ... a tiny bit has huge effects and side effects, and a tiny bit more massively unpleasant, so titrate particularly slowly.

Then maybe a little retatrutide later, but not as a main driver.