Can someone explain how reta feels compared to tirz?

clayd

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I'm on tirz, I like it, I'm not thinking of switching. But I keep seeing that reta has better clinical trial results, and has a third mechanism of action. But I also see people say it doesn't have great appetite suppression compared to tirz or sema.

If it's not suppressing appetite, what is it doing to make you eat less and lose weight? How does it feel? Especially compared to tirz if you've tried both
 
Absolutely no suppression from 2mg or 4mg Reta. I was on 7.5mg Tirz then decided to stack with reta as a last push for the last 15lbs.

Idk what or how Reta does it, but those last 15lbs FELL OFF. I was dosing Tirz every 5 days, reta 2 days after Tirz.

I think if you don't struggle with overthinking about food, reta might be a solid single choice for you. But if you do, it's a good option to stack with a good suppression.

If your looking for something different then Tirz, Survo is a great place to start too
 
clayd said:
I'm on tirz, I like it, I'm not thinking of switching. But I keep seeing that reta has better clinical trial results, and has a third mechanism of action. But I also see people say it doesn't have great appetite suppression compared to tirz or sema.

If it's not suppressing appetite, what is it doing to make you eat less and lose weight? How does it feel? Especially compared to tirz if you've tried both
Click to expand...
For me, Reta has stronger appetite suppression than Tirz. It also seems to punish me if I do eat, making me immediately regret my choices. I don’t get nauseous or anything. I just feel disgusting after I eat more than absolutely necessary, so I focus on my protein intake and more nutrient dense food. It makes me not enjoy eating like I used to.

Less fatigue with Reta than Tirz as well. I have never tried Sema, so nothing for me to compare it to.
 
I dropped 5mg of T and went to 2mg of R for 3 weeks now. Haven't lost any weight in that time, and I'm eating a little more than I was before. Moving up to 4mg soon though.
 
I tried both Sema and tirz-had severe gout and stomach cramps from both. Literally gout every 2 weeks vs 1-2 times per year prior. With Reta I have good appetite suppression, no breakfast, healthy smoothie for lunch and normal dinner. Side effects- some insomnia 2x per week. Normal slow digestion- energy levels have been high. Down 21 from 243 starting weight in six weeks. Currently on 2mg grey market Reta.
 
I️ really like tirz, but thought I’d switch to Reta for the last 15 pounds to goal weight. Reta does not like me if I️ do not eat at least three times a day. However, Reta likes those three times to be very small meals. I️ frequently feel overfull. With tirz I️ felt great after I️ ate. I️ am less tired on Reta and I️ have started to go to the gym. I️ am only two doses in at 2mg, so I️ will keep going to be able to make an informed decision about Reta. I️ did lose five pounds the first week but up and down a pound the second. My gut instinct is that I️ will return to tirz at some point. I️ was only at 5mg tirz when I️ switched with a 30lb weight loss over 3 months. Reta doesn’t cancel the food noise but it does really manage portion control. I️ hope this helps.
 
I was planning to be on Tirz for life…until I tried Reta. With Tirz I dropped weight quickly. Food noise faded away and back pain (severe degenerative disc disease) vanished. But I woke up with daily headaches (albeit helped with Tylenol), constipation (despite triple doses of Metamucil) and the fatigue was pretty debilitating.
Reta—now that I’m on 5 mg—gives me most of the benefits of Tirz, with none of the drawbacks. Headache-free. No back pain. And while I have some food noise, I find that it serves me well now that I’m trying to maintain.
I kind of regret my last big Tirz purchase. It’s going to be Reta from me from here on. 😊
 
ThePepPlanner said:
Absolutely no suppression from 2mg or 4mg Reta. I was on 7.5mg Tirz then decided to stack with reta as a last push for the last 15lbs.

Idk what or how Reta does it, but those last 15lbs FELL OFF. I was dosing Tirz every 5 days, reta 2 days after Tirz.

I think if you don't struggle with overthinking about food, reta might be a solid single choice for you. But if you do, it's a good option to stack with a good suppression.

If your looking for something different then Tirz, Survo is a great place to start too
Click to expand...
Survo as a replacement or in combination with Tirz?
 
AndyPanda said:
It also seems to punish me if I do eat, making me immediately regret my choices. I don’t get nauseous or anything. I just feel disgusting after I eat more than absolutely necessary
Click to expand...

Reta is just like this for me too.

I have been on 2 mg for 10 weeks now and these effects have lessened a great deal since the first few weeks, but I am still losing weight.
 
Garbo said:
I'd venture to guess that it's because a lot of (even most?) other people don't feel that same sensation/don't perceive it that way?
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didn't you almost ruin your heart on reta? increased heart rate is in the study and happens to most.
mine went straight to 130.
 
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raw_oyster_eater said:
didn't you almost ruin your heart on reta? its right in the study and happens to most.
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The study has an avg 8bpm for ~4 months before it starts returning back to normal. That's hardly "ruining" someone's heart. All glp1's actually have an increased heart rate effect which can at least partially be attributed to lowered blood pressure.
 
raw_oyster_eater said:
didn't you almost ruin your heart on reta? its right in the study and happens to most.
Click to expand...

Ouch.

My answer was about the feeling, raw. The feeling you described of your heart jumping out of your chest.

I did not have that feeling on Reta — although as you have so pointedly reminded me, I did experience a serious heart issue, that I have described elsewhere. And I talked about it only to perhaps help someone avoid my stupid mistake. Because I hate talking about it.

As you know, raw, my stupid mistake was ignoring that my heart rate increased way more than the expected average; and I ignored it for a very long time. Because I felt great on reta. And I paid a steep price for that stupidity.

You, however, did not make a stupid mistake. Because when you felt your heart was jumping out of your chest, you stopped taking Reta.

So, well done, you.
 
zpped said:
The study has an avg 8bpm for ~4 months before it starts returning back to normal. That's hardly "ruining" someone's heart. All glp1's actually have an increased heart rate effect which can at least partially be attributed to lowered blood pressure
Click to expand...
I think its worse than the study reflects and some people are going to have real serious problems. if you are susceptible it can cause arrhythmia.

some say some of these peps will accelerate cancer and such but reta will won't fool around and take years to waste you.
 
zpped said:
The study has an avg 8bpm for ~4 months before it starts returning back to normal. That's hardly "ruining" someone's heart. All glp1's actually have an increased heart rate effect which can at least partially be attributed to lowered blood pressure.
Click to expand...
26 weeks in my hr is around 90-100 everyday. mileage varies.
 
raw_oyster_eater said:
I think its worse than the study reflects and some people are going to have real serious problems. if you are susceptible it can cause arrhythmia.

some say some of these peps will accelerate cancer and such but reta will won't fool around and take years to waste you.
Click to expand...
Every medication can be harmful to someone. EL already started a trial, a year ago ,specifically recruiting people with a variety of heart issues. It's been going well so far.
www.mountsinai.org

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes) | Mount Sinai - New York

www.mountsinai.org

IndividualPickle said:
26 weeks in my hr is around 90-100 everyday. mileage varies.
Click to expand...
I'm not sure what you're getting at because you didn't include a point or any of the relevant information?
 
Tirz made all of the food I ate taste wrong. Nothing was good anymore. I’ve never dealt with food noise and I’m not hungry on either drug. Terrible fatigue with Tirz, both cause me severe constipation. But on Reta my coffee is tasty again and I’m not exhausted all the time. I lost weight faster on Tirz but I’m titrating slow and am about to take my second dose of 8 mg Reta. Plus this is my first stall, so I’m trying to be patient. I didn’t have heart rate issues, but my resting heart rate is 56. It went up to 62 when I first started Reta but I’m back to 56-58. So not everyone gets the increased heart rate. I kind of wish I could have stayed on Tirz to lose faster, then use Reta for maintenance- but the thought of dealing with that awful fatigue again is enough to make me say no.
 
I was on TIrz a year, then Sema for 4 months now Reta for little over two months. My first two months I was STARVING and gain around 5lbs. But I noticed right away I had tons of energy and I felt more productive. ( I think I became more positive and nicer too) I just finished my second week of 6mg and I’m starting to finally notice appetite suppression but not the same with TIrz. With Triz I lost all the joy in food (and joy of everything else around me) now I eat and a few bites in I look at the food and want to grow it away. It’s hard to explain but my mind feels better on Reta. I’ve also lost 8lbs since moving to 6mg. Reta kind of gave me “hope” back
 
Yes, reta will kill you, very bad for your heart, just KABOOM!! Many people are saying it, hey do you have any of that poison you need to get rid of? I might be able to help you out.
 
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