Retatrutide's effect on alcohol cravings?

[Glp1judd]

Tirz has about completely removed my desire to drink. I’ve been heavy drinker at times, and completely sober at times. This seems different, just zero desire - there’s been the same bottles on my counter for months!

 

[chmuse]

Jealous, I am not experiencing this.

Every study I've seen says sema is best because it bonds best to the right receptor. Maybe try stacking a small amount of sema?

 

[Superfluous]

I'm currently on Tirz and doing my annual Dry January - and I think it's definitely much easier than in previous years. Before after a long day's working it would have been sitting in my mind - now I'm just finishing work and I don't even want it. The only time it's been hard is when I've went to the pub to meet friends and watch football - or had a meal out last weekend - being surrounded by people drinking makes you have the social urge, rather than a chemical addiction.

 

[hotdog!]

Well the anti-drinking effects of tirz have greatly diminished for me. The disinterest in drinking just didn't last for me. I'm sad and disappointed about that, but I will keep trying to quit and at least cut down. If only because I'm pretty sure that drinking is effectively canceling out much if not all of the helpful Tirz effects, not just weight loss.

 

[mopo89]

Well the anti-drinking effects of tirz have greatly diminished for me. The disinterest in drinking just didn't last for me. I'm sad and disappointed about that, but I will keep trying to quit and at least cut down. If only because I'm pretty sure that drinking is effectively canceling out much if not all of the helpful Tirz effects, not just weight loss.

I'm sorry to hear that!

It's definitely died down a bit for me and I get cravings now, which had completely disappeared for me (but could also be attributed to stress right now, idk). But I figure it gives me a chance to practice will power and to continue finding ways to de-stress that don't involve alcohol!

 

[Buksos]

Since starting Reta in October I have completely wiped out alcohol. I’ve even tried to have a beer or whiskey and I just can’t stomach it.

 

[GimmeABreak]

Have you done a full panel? My blood work reads well, but you can still have liver issues/ cirrhosis even if your blood looks okay.

First link I found on it

What is included in a full panel?

i looked at the link you provided and it announces the findings from a 2021 study but I can't see where any medical facilities are actually using the Cirrus algorithm.

 

[chmuse]

What is included in a full panel?

i looked at the link you provided and it announces the findings from a 2021 study but I can't see where any medical facilities are actually using the Cirrus algorithm.

Honestly.... I'm not 100% sure all of them. I know it involves more than just AST and ALT. My point was more that liver damage can be sneaky and you won't always see it on basic blood tests until it's pretty far gone.

 

[G Vice]

What is included in a full panel?

i looked at the link you provided and it announces the findings from a 2021 study but I can't see where any medical facilities are actually using the Cirrus algorithm.

Agree. The researcher in that study in the UK talks about a "fingerprint" pointing to cirrhosis in basic blood work when liver enzymes ALT and AST are normal, but makes no mention of what specifically those other markers are in the blood work. It's like they left out this information on purpose.

 

[Grannylearner]

As an update, I'm happy to report that the desire to drink is GREATLY dampened. I have not gone completely dry, but instead of 1 bottle of wine or 6-8 beers nightly, I have 2 beers when we go out to dinner on the weekend. I have gone weeks without drinking or wanting to drink.
One Friday night I stopped at one beer. ONE. That has never happened in my life. Before I would have said, "What is the point of ONE? Doesn't even get me drunk!" Now I simply don't want another. Like, what *is* that???
It's really quite amazing, such that I'm dying to know a detailed, scientific, Biochem 101 explanation of exactly how this mechanism works. It must be very tied to addiction pathways. It's fascinating to me.

I’m exactly where you were. So the retratrutide is more effective than just tirz? Can you say more about the exact changes you made? Thank you!

 

[hotdog!]

I’m exactly where you were. So the retratrutide is more effective than just tirz? Can you say more about the exact changes you made? Thank you!

Sorry, since I originally asked about Reta's effects on alcohol consumption, it gives the impression I was talking about Reta, but I am talking about the effects of Tirzepatide in these subsequent posts. But if you read through to the end, you'll see that effect is greatly dampened now, just a few months later. I can certainly drink through the Tirz effects that made me uninterested in alcohol. And I did that for most of December, part of January. For a few weeks I went right back to the nightly bottle of wine or 6-7 beers. I lost no weight during that time, unsurprisingly.

But it is still easier to make the decision to not drink when I am on tirz. Now that I cut out drinking again, the weight is slowly moving back down again.

I tried Reta for about 6-7 weeks but the skin sensitivity was a big issue, plus I had a history of a very painful neuropathy issue that resolved long ago and I am very afraid of getting again. I also disliked the increased feeling of hunger, specifically cravings for sweets which were previously never an issue for me. So I was never able to see first hand how much better Reta was at suppressing alcohol cravings.

 

[Grannylearner]

Sorry, since I originally asked about Reta's effects on alcohol consumption, it gives the impression I was talking about Reta, but I am talking about the effects of Tirzepatide in these subsequent posts. But if you read through to the end, you'll see that effect is greatly dampened now, just a few months later. I can certainly drink through the Tirz effects that made me uninterested in alcohol. And I did that for most of December, part of January. For a few weeks I went right back to the nightly bottle of wine or 6-7 beers. I lost no weight during that time, unsurprisingly.

But it is still easier to make the decision to not drink when I am on tirz. Now that I cut out drinking again, the weight is slowly moving back down again.

I tried Reta for about 6-7 weeks but the skin sensitivity was a big issue, plus I had a history of a very painful neuropathy issue that resolved long ago and I am very afraid of getting again. I also disliked the increased feeling of hunger, specifically cravings for sweets which were previously never an issue for me. So I was never able to see first hand how much better Reta was at suppressing alcohol cravings.

Thank you for responding! I have heard that the alcohol cravings aren’t as reduced for people who are not obese. I am just a little overweight, so I wondered if that might be why I haven’t experienced the lack of interest or distaste for alcohol. I noticed one comment suggested stacking a bit of semi with the tirz. Maybe I will try that. Of course, I agree that other recovery programs may be helpful, but I’m looking at both paths.

 

[chmuse]

Thank you for responding! I have heard that the alcohol cravings aren’t as reduced for people who are not obese. I am just a little overweight, so I wondered if that might be why I haven’t experienced the lack of interest or distaste for alcohol. I noticed one comment suggested stacking a bit of semi with the tirz. Maybe I will try that. Of course, I agree that other recovery programs may be helpful, but I’m looking at both paths.

I've only been on sema, but I can confirm it works well. Anecdotes I've seen seem to show sema is best for addictive behaviors.

 

[hotdog!]

Thank you for responding! I have heard that the alcohol cravings aren’t as reduced for people who are not obese. I am just a little overweight, so I wondered if that might be why I haven’t experienced the lack of interest or distaste for alcohol. I noticed one comment suggested stacking a bit of semi with the tirz. Maybe I will try that. Of course, I agree that other recovery programs may be helpful, but I’m looking at both paths.

Oh no, I am obese, started at class III and now at class I. So I can't say whether that's true for others, but it's not the case for me. For me it is more a Pavlovian conditioning, functional type of alcohol addiction. But still an addiction, I'm not deluding myself about that.

 

[Grannylearner]

Oh no, I am obese, started at class III and now at class I. So I can't say whether that's true for others, but it's not the case for me. For me it is more a Pavlovian conditioning, functional type of alcohol addiction. But still an addiction, I'm not deluding myself about that.

Moving from class 3 to 1 is fantastic -that is a lot to celebrate right there. I’m also very functional which makes it easier to ignore the negative consequences. When I have had periods of sobriety, my anxiety is lower. Wishing you the best.

 

[Grannylearner]

I've only been on sema, but I can confirm it works well. Anecdotes I've seen seem to show sema is best for addictive behaviors.

Thank you. Has the effect been consistent over time? Or did you notice less or more after several weeks on it?

 

[chmuse]

Thank you. Has the effect been consistent over time? Or did you notice less or more after several weeks on it?

Volume wise it was immediately down like 95%. I just didn't feel like drinking as much. By 2 months in I managed to be sober a solid two weeks, before I ended up drinking emotionally. I'd say I'm still down 90% from the amount I was drinking before sema- if I go out, I have a shot or two or just don't feel like drinking at all. I'm still capable of getting shitty drunk if something gets me all up in my feels, but I pay the price the next day and it puts me off trying again for a while.

Context: my first shot was Oct 1

 

[bbrewer]

I go for vodka and diet sports drinks. Seems to keep my electrolytes more balanced especially doing keto and glp1.

 

[hotdog!]

Yes, I, like most obese people, know all about the calories.

I have preferences for certain reasons that have to do with attempts at self-moderation. I tend to guzzle when I drink, so if I'm guzzling liquor I will end up way, way more drunk far quicker than I intend. In fact, if I drink liquor drinks I will end up passed-out drunk and probably close to alcohol poisoning with the world's most debilitating hangover the next day. The volume and feeling of fullness from beer and wine is a safety that slows me down.

 

[bbrewer]

Yes, I, like most obese people, know all about the calories.

I have preferences for certain reasons that have to do with attempts at self-moderation. I tend to guzzle when I drink, so if I'm guzzling liquor I will end up way, way more drunk far quicker than I intend. In fact, if I drink liquor drinks I will end up passed-out drunk and probably close to alcohol poisoning with the world's most debilitating hangover the next day. The volume and feeling of fullness from beer and wine is a safety that slows me down.

I have the exact same issue, years of beer drinking gives me a certain rhythm. It is not suitable for wine or stronger mixed drinks. I mix vodka and diet sports drinks down to about 4.5%. Unsweet tea with diet lemonade is also good. I get full and slow down.