All of you have to stop!!!

Peloma

Peloma

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Every time I think i have gotten the best peps for my research, one of you pulls another one out your ass and sends my down a new rabbit hole...

I swear I feel like I'm playing Pokémon Go... Gotta catch em all!

Thank you and fuck you at the same time!
 
Peloma said:
Every time I think i have gotten the best peps for my research, one of you pulls another one out your ass and sends my down a new rabbit hole...

I swear I feel like I'm playing Pokémon Go... Gotta catch em all!

Thank you and fuck you at the same time!
Click to expand...
It is a slippery slope, and similar to other addictions.. Nothing beats those GLP-1 results...

Chasing that pink day dragon.. lol
 
Peloma said:
Every time I think i have gotten the best peps for my research, one of you pulls another one out your ass and sends my down a new rabbit hole...

I swear I feel like I'm playing Pokémon Go... Gotta catch em all!

Thank you and fuck you at the same time!
Click to expand...
Be conservative with your money. Many of them are snake oil.
 
Peloma said:
True. I've stuck to the ones with beat research results on the boards.

So far: Tirz, Selank, Semax, SS-31, Mots-C.

On order: Reta, Nad+, wolverine serum...

And then I'm done!
Click to expand...
Tirzepatide, MOTS-C, and Glutathione are my favorites. NAD+ seems to vary depending on where I’ve bought it.

I like GHK-Cu on its own. The Glow protocol has no value added, especially for the price difference.
 
AndyPanda said:
Tirzepatide, MOTS-C, and Glutathione are my favorites. NAD+ seems to vary depending on where I’ve bought it.

I like GHK-Cu on its own. The Glow protocol has no value added,
Click to expand...

AndyPanda said:
Tirzepatide, MOTS-C, and Glutathione are my favorites. NAD+ seems to vary depending on where I’ve bought it.

I like GHK-Cu on its own. The Glow protocol has no value added, especially for the price difference.
Click to expand...
Dammit, Panda! 😵‍💫
 
geoguy78 said:
There's a reason most peptides we see the vendors selling, aren't commercially available. It's not due to some big pharma conspiracy to keep people sick, it's because the peptides don't do much if anything.
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many of them (selank, semax, bpc, tb4, pt141, CJC, melanotan, and others) are not patentable in the US for a variety of reasons and therefore there is no profit to be had in investing in the clinical trials required to bring them to market. selank and semax im a little iffy about, but the rest of that list are plenty effective.
 
exploitedworkerbee said:
many of them (selank, semax, bpc, tb4, pt141, CJC, melanotan, and others) are not patentable in the US for a variety of reasons and therefore there is no profit to be had in investing in the clinical trials required to bring them to market. selank and semax im a little iffy about, but the rest of that list are plenty effective.
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Other than Semax and Selank (personal experience with Selank was a bust for me) the others you mentioned have pretty strong bodies of evidence backing their therapeutic effects or they are actually marketed or were marketed (I'm pretty sure melanotan 1 is available with scrip, melanotan 2 was modified into a drug that's on market). I'm thinking more about certain others...... cough...... like AOD...... cough as just one example. The creators of AOD9604 specifically stopped research because it was ineffective, yet people continue to throw money at it for its "miraculous" fat burning ability 🙄
 
geoguy78 said:
Other than Semax and Selank (personal experience with Selank was a bust for me
Click to expand...
I have high hopes for the selank and semax I have coming in. I hope this isn't the case for me.

I am also hoping the SS-31 and Mots function as advertised. I feel like my body could benefit from some cell reconstruction and added energy production.

The Nad is the one that I'm buying mostly because everyone else is...
 
Peloma said:
I have high hopes for the selank and semax I have coming in. I hope this isn't the case for me.

I am also hoping the SS-31 and Mots function as advertised. I feel like my body could benefit from some cell reconstruction and added energy production.

The Nad is the one that I'm buying mostly because everyone else is...
Click to expand...
Tirz
SS31
Pinealon
Ghkcu with BPC TB4 and KPV
TA1 Th
Dsip
Epi
And my new favorite Selank IN - now getting some of the best sleep I've had in many years. Sub Q selank semax I wasn't a fan of but the already prepared IN is completely different.
Honorable mentions domestic Lipo C and only PGB NAD.
Favorite cognitive : P21.
All game changers for me ! My new medicine cabinet ! 😴😷💃🏽🏃🏽‍♀️🦾🤓
Big pharma and meds that just cover the issue and not fix it can suck it !
 
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I would love any feed back as I am not trained in this field and far from an authority on any of this.
I am also interested in Hgh, but it is requiring much more reading for my comfort level.
SS-31 seems like a great primer if you are planning further peptide therapy or cycling-
I was interested in Glow, BPC, and Ghk but angiogenesis was a little concerning from my personal history, so I don't want to rush into those.
This is a good summary on what I have found on the 3 in several different locations-
SS-31
There's some emerging evidence and theoretical support suggesting that cycling SS-31 (Elamipretide) can enhance the efficacy of future peptide therapies.
🧬 How SS-31 May Enhance Future Peptide Effectiveness:
🔋 1.
SS-31 targets and stabilizes cardiolipin in mitochondrial membranes, reducing oxidative stress and improving ATP production. This can "prime" cells to respond better to other peptides that depend on mitochondrial health (like MOTS-c, NAD+, GH-releasing peptides, etc.).
⚡ 2.
By enhancing mitochondrial function, SS-31 boosts cellular energy availability — potentially making it easier for other peptides to do their work (e.g., fat metabolism, muscle repair, cognitive effects).
🧯 3.
Lower systemic inflammation can increase the receptor sensitivity and bioavailability of subsequent peptide treatments.
📈 4.
Some people use SS-31 as a way to recover between cycles of heavier peptides or stacks — helping to reduce systemic stress and maintain overall metabolic function.

🔁 Example Synergy:​

  • SS-31 first cycle → improved mitochondrial resilience
  • Followed by MOTS-c or NAD+ → better uptake, energy efficiency, and fat metabolism
  • Stacking with Lipo-C or CoQ10 → further supports cell energy and detox pathways
✅ Summary:

Cycling SS-31 may enhance the body's baseline function, setting the stage for more effective and efficient use of future peptides — especially those related to energy metabolism, longevity, and fat loss.
Click to expand...

⚠️ BPC and tumor history: use with caution​


BPC-157 is a synthetic peptide known for its regenerative effects on tissue, gut healing, joint repair, and inflammation reduction. However, because of its powerful angiogenic (blood vessel forming) and growth-promoting properties, there is concern regarding its use in people with a history of tumors or cancer.

🚩 Potential Concerns:
  1. Angiogenesis (blood vessel growth):
    • Tumors rely on blood vessel growth to feed themselves.
    • BPC-157 promotes angiogenesis — helpful for healing, but theoretically could feed tumor growth if any dormant cells remain.
  2. Cell Proliferation:
    • BPC-157 may upregulate certain growth pathways.
    • That could be a risk in individuals with a cancer history, especially hormone-sensitive or vascular tumors.
  3. Lack of Human Studies in Cancer Patients:
    • There are no long-term human studies confirming safety in people with a history of tumors or cancer.
    • Most data comes from animal studies — encouraging for healing, but not definitive on safety in post-tumor conditions.
✅ What Some Clinicians Suggest:
  • Avoid use unless cleared by an oncologist or integrative medicine specialist.
  • If used, limit to short-term cycles and monitor markers (inflammatory, tumor markers, etc.).
  • Consider alternatives with less growth signaling (like curcumin, omega-3s, NAC, or red light therapy) for healing if tumor history is present.
🧬 Alternatives That Support Healing but Are Generally Safer:
  • Taurine
  • Glutamine (for gut healing)
  • Collagen peptides
  • Red light therapy
  • Mitochondrial support peptides like SS-31 (less proliferative risk)
Click to expand...
GHK-Cu is less risky than BPC-157 in this context, but still not 100% without concern. Here's why:

🔬 What GHK-Cu Does:​

  • Promotes wound healing
  • Supports collagen production
  • Improves skin, hair, and tissue regeneration
  • Has antioxidant & anti-inflammatory effects
  • Modulates gene expression (can upregulate or downregulate many genes)
🧪 Tumor Concerns:
  1. GHK-Cu is not directly pro-cancer, and it has actually shown anti-cancer properties in some studies — including:
    • DNA repair
    • Inhibition of some cancer-related gene expression
    • Copper regulation (important in cancer metabolism)
  2. But copper can be a double-edged sword:
    • Copper is essential for healing — but also plays a role in angiogenesis, which tumors can use.
    • If copper levels are already high, GHK-Cu could theoretically contribute to unwanted growth in certain environments.
  3. Most of this data is cellular and animal-based — so in humans, especially post-cancer, we don’t have enough long-term studies to be definitive.
Click to expand...
 
That's a pass on copper injections for me. Cancer and a painful reaction? No gracias.
 
Skidude said:
I would love any feed back as I am not trained in this field and far from an authority on any of this.
I am also interested in Hgh, but it is requiring much more reading for my comfort level.
SS-31 seems like a great primer if you are planning further peptide therapy or cycling-
I was interested in Glow, BPC, and Ghk but angiogenesis was a little concerning from my personal history, so I don't want to rush into those.
This is a good summary on what I have found on the 3 in several different locations-
SS-31
Click to expand...
i'm also not trained on it but i find the logic behind potentially accelerating existing tumor growth to be compelling. i wouldn't touch BPC if i had any significant risk factors for any cancer.

that said, it's magical stuff.
 
Peloma said:
That's a pass on copper injections for me. Cancer and a painful reaction? No gracias.
Click to expand...
Not necessarily cancer or anything negative. only increase possibility of tumor growth. (from what I have read).
I just approach with caution as a result of having some history there. YMMV>
 
Dude, after going through that shit with my wife, I would like to keep big C as far from me as possible. Granted, I am willing to do research on my subject with impunity; but if there are cancer markers out there to avoid, I will try to do so.

I have read that BPC is great, but I haven't necessarily found my need yet.
 
Peloma said:
That's a pass on copper injections for me. Cancer and a painful reaction? No gracias.
Click to expand...
I thought it might sting too but in my case it's completely painless. I use 12mm needles which might help.
 
Peloma said:
Dude, after going through that shit with my wife, I would like to keep big C as far from me as possible. Granted, I am willing to do research on my subject with impunity; but if there are cancer markers out there to avoid, I will try to do so.

I have read that BPC is great, but I haven't necessarily found my need yet.
Click to expand...
I just wanted to point out that, it is like watering a seed. It will only grow with water if a seed is present. There was nothing about it being carcinogenic, only promoting blood vessel growth. (Angiogenesis). This is the water in that scenario, you still need the seed present, from what I understand.
 
Angiogenesis shouldn't cause new tumors, but it is the turbo button for tumor growth. TB-500 has some evidence of metastasization of existing tumors as well.

I've not had great luck with my BPC/TB experiments for dealing with tendinopathy. I tried it for dealing with some distal bicep tendon issues and it didn't seem to heal any faster than regular rehab in the past. I'm just now finishing up some rehab on one of my tricep tendons and opted to forego the bpc/tb this time around, and it healed just as fast.

Not sure if I'm a non-responder or what. I'll probably try again at some point, but I can't say I was sold on them. (Honestly, outside of GLP-1s and HGH I've not found any peptides to have significant impact so far)
 
hexagonal said:
Angiogenesis shouldn't cause new tumors, but it is the turbo button for tumor growth. TB-500 has some evidence of metastasization of existing tumors as well.

I've not had great luck with my BPC/TB experiments for dealing with tendinopathy. I tried it for dealing with some distal bicep tendon issues and it didn't seem to heal any faster than regular rehab in the past. I'm just now finishing up some rehab on one of my tricep tendons and opted to forego the bpc/tb this time around, and it healed just as fast.

Not sure if I'm a non-responder or what. I'll probably try again at some point, but I can't say I was sold on them. (Honestly, outside of GLP-1s and HGH I've not found any peptides to have significant impact so far)
Click to expand...
Because the mechanism of action for BPC/TB shouldn't have any benefit for tendonopathy.
 
zpped said:
Because the mechanism of action for BPC/TB shouldn't have any benefit for tendonopathy.
Click to expand...
Uh.

That is explicitly one of the primary things they have been studied for?
pubmed.ncbi.nlm.nih.gov

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration - PubMed

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Collagen deposition is an incredibly important aspect to tendon repair as well
pubmed.ncbi.nlm.nih.gov

Thymosin beta4 accelerates wound healing - PubMed

Angiogenesis is an essential step in the repair process that occurs after injury. In this study, we investigated whether the angiogenic thymic peptide thymosin beta4 (Tbeta4) enhanced wound healing in a rat full thickness wound model. Addition of Tbeta4 topically or intraperitoneally increased...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Inflammation is another one of the primary causes of tendinopathy, and inflammation reduction is another supposed benefit of these.
www.nature.com

Inflammatory mechanisms in tendinopathy – towards translation - Nature Reviews Rheumatology

Tendon disorders are common and confer a large socioeconomic burden. This Review discusses the role of inflammatory mechanisms in tendon homeostasis and resolution of tendon damage, which are crucial to consider in developing novel therapeutics for tendinopathies.
www.nature.com www.nature.com

Angiogenesis and VEGF are also extremely important to tendon repair, and TB-500 increases VEGF production and BPC-157 increases VEGF receptors.

The Role of Vascular Endothelial Growth Factor in Tendon Healing - PMC

Angiogenesis is crucial to facilitate tendon healing, such as delivering oxygen and nutrients, removing waste products, and controlling immune responses. Vascular endothelial growth factor (VEGF) is one of the most vital angiogenic factors that ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

If they do what the claims are, then they should 100% aid in tendinopathy. I'm not really sure what you're talking about.
 
New potential uses for popular peptides 🙂

MOTS-c:

The present study is the first to provide evidence that MOTS-c may be a promising therapeutic target for neuropathic pain.
Click to expand...
www.spandidos-publications.com

Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)

Mitochondria‑derived peptides (MDPs) are a unique class of peptides encoded by short open reading frames in mitochondrial DNA, including the mitochondrial open reading frame of the 12S ribosomal RNA type‑c (MOTS‑c). Recent studies suggest that MDPs offer therapeutic benefits in various diseases...
www.spandidos-publications.com
In a study in which vascular calcification was induced in rats through treatment with vitamin D3 and nicotine, subsequent treatment with MOTS-c markedly reduced blood pressure, preserved normal heart structure and decreased vascular stiffness. These findings demonstrate that MOTS-c can improve cardiovascular and vascular abnormalities caused by vascular calcification.
Click to expand...

SS-31:

SS-31 markedly improved the behavioral indices and significantly mitigated the damage to the sciatic nerve
Click to expand...
link.springer.com

SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop - The Journal of Headache and Pain

Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller peptide (SS-31) is a new mitochondria-targeted tetrapeptide molecule that has been...
link.springer.com link.springer.com
SS-31 has the potential to be an effective drug candidate for headache treatment.
Click to expand...

SS-31, as a mitochondrial protectant, could improve mitochondrial function and promote the healing of tendinopathy.
Click to expand...
Google Gemini said:
Studies have indicated that SS-31 can improve mitochondrial function in tendon cells and promote the healing process in injured tendons.
Click to expand...

GHK-Cu:

Research in animal models has indicated that GHK-Cu may protect diabetic rats from kidney-damaging fibrosis by increasing decorin, an anti-inflammatory proteoglycan.
Click to expand...

The GHK-Cu peptide should be considered a promising neuroprotective agent capable of preventing the development of common age-associated neurodegenerative disorders.
Click to expand...

"Just when I think I know everything that these peptides treat, some other benefit emerges"
~ @amynurse
 
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Valerie said:
And my new favorite Selank IN - now getting some of the best sleep I've had in many years. Sub Q selank semax I wasn't a fan of but the already prepared IN is completely different.
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Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?
 
scarywood75 said:
Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?
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Sub q selank and semax were not for me. I didn't have good results. Sub q selank made me tired and irritable; not relaxed and semax jittery. Will effect everyone differently of course.

Nasal selank has been great for sleep with my Epi Dsip sleep stack as well as general anxiety. It's just enough of a dose for me with a relaxing effect.
 
scarywood75 said:
Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?
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They work for me subq. .5 to 1mg is perfect. I took a bigger dose to see what would happen, and I didnt like that feeling. Felt like I had taken xanax.
 
Peloma said:
They work for me subq. .5 to 1mg is perfect. I took a bigger dose to see what would happen, and I didnt like that feeling. Felt like I had taken xanax.
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That's great !!

I tried 150-200mcg; very low. Turns out even lower is better for me ... lol 😂 and or maybe it's the direct to blood brain barrier; idk but 1-2 squirts is plenty.
 
scarywood75 said:
Just selank or semax too?
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I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.
 
AndyPanda said:
I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.
Click to expand...
Interesting, what effect do you have from it?
 
AndyPanda said:
I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.
Click to expand...
I've heard it can be disappointing for some. Not in my case. I guess I'm sensitive to these. I may hold off on them to see Mots-c on its own.
 
AndyPanda said:
I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.
Click to expand...
I have been looking into Pinealon. Have you stacked it with Epitalon?
 
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