All of you have to stop!!!

[Peloma]

Dude, after going through that shit with my wife, I would like to keep big C as far from me as possible. Granted, I am willing to do research on my subject with impunity; but if there are cancer markers out there to avoid, I will try to do so.

I have read that BPC is great, but I haven't necessarily found my need yet.

 

[Exolon75]

That's a pass on copper injections for me. Cancer and a painful reaction? No gracias.

I thought it might sting too but in my case it's completely painless. I use 12mm needles which might help.

 

[Skidude]

Dude, after going through that shit with my wife, I would like to keep big C as far from me as possible. Granted, I am willing to do research on my subject with impunity; but if there are cancer markers out there to avoid, I will try to do so.

I have read that BPC is great, but I haven't necessarily found my need yet.

I just wanted to point out that, it is like watering a seed. It will only grow with water if a seed is present. There was nothing about it being carcinogenic, only promoting blood vessel growth. (Angiogenesis). This is the water in that scenario, you still need the seed present, from what I understand.

 

[Garbo]

True. I've stuck to the ones with beat research results on the boards.

So far: Tirz, Selank, Semax, SS-31, Mots-C.

On order: Reta, Nad+, wolverine serum...

And then I'm done!

"Sure, Jan."

 

[Garbo]

Reta, hgh, bpc. The holy trinity.

Innnnnteresting ...

 

[Morbius]

I know Reta and BPC together were a game changer.

I just started reta and have BPC arriving next week so I am very curious myself...

 

[brentm]

Reta, hgh, bpc. The holy trinity.

Just for clarification, is HGH191AA the same as HGH you're referring to?

 

[hexagonal]

Angiogenesis shouldn't cause new tumors, but it is the turbo button for tumor growth. TB-500 has some evidence of metastasization of existing tumors as well.

I've not had great luck with my BPC/TB experiments for dealing with tendinopathy. I tried it for dealing with some distal bicep tendon issues and it didn't seem to heal any faster than regular rehab in the past. I'm just now finishing up some rehab on one of my tricep tendons and opted to forego the bpc/tb this time around, and it healed just as fast.

Not sure if I'm a non-responder or what. I'll probably try again at some point, but I can't say I was sold on them. (Honestly, outside of GLP-1s and HGH I've not found any peptides to have significant impact so far)

 

[zpped]

Angiogenesis shouldn't cause new tumors, but it is the turbo button for tumor growth. TB-500 has some evidence of metastasization of existing tumors as well.

I've not had great luck with my BPC/TB experiments for dealing with tendinopathy. I tried it for dealing with some distal bicep tendon issues and it didn't seem to heal any faster than regular rehab in the past. I'm just now finishing up some rehab on one of my tricep tendons and opted to forego the bpc/tb this time around, and it healed just as fast.

Not sure if I'm a non-responder or what. I'll probably try again at some point, but I can't say I was sold on them. (Honestly, outside of GLP-1s and HGH I've not found any peptides to have significant impact so far)

Because the mechanism of action for BPC/TB shouldn't have any benefit for tendonopathy.

 

[hexagonal]

Because the mechanism of action for BPC/TB shouldn't have any benefit for tendonopathy.

Uh.

That is explicitly one of the primary things they have been studied for?

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration - PubMed

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles...

pubmed.ncbi.nlm.nih.gov

Collagen deposition is an incredibly important aspect to tendon repair as well

Thymosin beta4 accelerates wound healing - PubMed

Angiogenesis is an essential step in the repair process that occurs after injury. In this study, we investigated whether the angiogenic thymic peptide thymosin beta4 (Tbeta4) enhanced wound healing in a rat full thickness wound model. Addition of Tbeta4 topically or intraperitoneally increased...

pubmed.ncbi.nlm.nih.gov

Inflammation is another one of the primary causes of tendinopathy, and inflammation reduction is another supposed benefit of these.

Inflammatory mechanisms in tendinopathy – towards translation - Nature Reviews Rheumatology

Tendon disorders are common and confer a large socioeconomic burden. This Review discusses the role of inflammatory mechanisms in tendon homeostasis and resolution of tendon damage, which are crucial to consider in developing novel therapeutics for tendinopathies.

www.nature.com

Angiogenesis and VEGF are also extremely important to tendon repair, and TB-500 increases VEGF production and BPC-157 increases VEGF receptors.

The Role of Vascular Endothelial Growth Factor in Tendon Healing - PMC

Angiogenesis is crucial to facilitate tendon healing, such as delivering oxygen and nutrients, removing waste products, and controlling immune responses. Vascular endothelial growth factor (VEGF) is one of the most vital angiogenic factors that ...

pmc.ncbi.nlm.nih.gov

If they do what the claims are, then they should 100% aid in tendinopathy. I'm not really sure what you're talking about.

 

[Calm Logic]

New potential uses for popular peptides

MOTS-c:

https://pubs.acs.org/doi/abs/10.1021/acschemneuro.3c00140

The present study is the first to provide evidence that MOTS-c may be a promising therapeutic target for neuropathic pain.

Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)

Mitochondria‑derived peptides (MDPs) are a unique class of peptides encoded by short open reading frames in mitochondrial DNA, including the mitochondrial open reading frame of the 12S ribosomal RNA type‑c (MOTS‑c). Recent studies suggest that MDPs offer therapeutic benefits in various diseases...

www.spandidos-publications.com

In a study in which vascular calcification was induced in rats through treatment with vitamin D3 and nicotine, subsequent treatment with MOTS-c markedly reduced blood pressure, preserved normal heart structure and decreased vascular stiffness. These findings demonstrate that MOTS-c can improve cardiovascular and vascular abnormalities caused by vascular calcification.

SS-31:

https://www.sciencedirect.com/science/article/pii/S0006291X24017649

SS-31 markedly improved the behavioral indices and significantly mitigated the damage to the sciatic nerve

SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop - The Journal of Headache and Pain

Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller peptide (SS-31) is a new mitochondria-targeted tetrapeptide molecule that has been...

link.springer.com

SS-31 has the potential to be an effective drug candidate for headache treatment.

https://journals.sagepub.com/doi/abs/10.1177/03635465221107943

SS-31, as a mitochondrial protectant, could improve mitochondrial function and promote the healing of tendinopathy.

Studies have indicated that SS-31 can improve mitochondrial function in tendon cells and promote the healing process in injured tendons.

GHK-Cu:

https://www.laweekly.com/ghk-cu-potential-and-functions/?utm_source=rss&utm_medium=rss&utm_campaign=ghk-cu-potential-and-functions

Research in animal models has indicated that GHK-Cu may protect diabetic rats from kidney-damaging fibrosis by increasing decorin, an anti-inflammatory proteoglycan.

https://onlinelibrary.wiley.com/doi/full/10.1155/2012/324832

The GHK-Cu peptide should be considered a promising neuroprotective agent capable of preventing the development of common age-associated neurodegenerative disorders.

"Just when I think I know everything that these peptides treat, some other benefit emerges"
~ @amynurse

 

[scarywood75]

And my new favorite Selank IN - now getting some of the best sleep I've had in many years. Sub Q selank semax I wasn't a fan of but the already prepared IN is completely different.

Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?

 

[Valerie]

Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?

Sub q selank and semax were not for me. I didn't have good results. Sub q selank made me tired and irritable; not relaxed and semax jittery. Will effect everyone differently of course.

Nasal selank has been great for sleep with my Epi Dsip sleep stack as well as general anxiety. It's just enough of a dose for me with a relaxing effect.

 

[Peloma]

Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?

They work for me subq. .5 to 1mg is perfect. I took a bigger dose to see what would happen, and I didnt like that feeling. Felt like I had taken xanax.

 

[Valerie]

They work for me subq. .5 to 1mg is perfect. I took a bigger dose to see what would happen, and I didnt like that feeling. Felt like I had taken xanax.

That's great !!

I tried 150-200mcg; very low. Turns out even lower is better for me ... lol and or maybe it's the direct to blood brain barrier; idk but 1-2 squirts is plenty.

 

[scarywood75]

They work for me subq. .5 to 1mg is perfect. I took a bigger dose to see what would happen, and I didnt like that feeling. Felt like I had taken xanax.

Just selank or semax too?

 

[Peloma]

Just selank or semax too?

Both. Used as needed. I did a week daily alternating am and pm.

 

[AndyPanda]

Just selank or semax too?

I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.

 

[scarywood75]

I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.

Interesting, what effect do you have from it?

 

[AndyPanda]

Interesting, what effect do you have from it?

Improved sleep, and clarity. I don’t know if the clarity is from the sleep or the drug.