All of you have to stop!!!

[Calm Logic]

New potential uses for popular peptides 🙂

MOTS-c:

https://pubs.acs.org/doi/abs/10.1021/acschemneuro.3c00140

The present study is the first to provide evidence that MOTS-c may be a promising therapeutic target for neuropathic pain.

Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)

Mitochondria‑derived peptides (MDPs) are a unique class of peptides encoded by short open reading frames in mitochondrial DNA, including the mitochondrial open reading frame of the 12S ribosomal RNA type‑c (MOTS‑c). Recent studies suggest that MDPs offer therapeutic benefits in various diseases...

www.spandidos-publications.com

In a study in which vascular calcification was induced in rats through treatment with vitamin D3 and nicotine, subsequent treatment with MOTS-c markedly reduced blood pressure, preserved normal heart structure and decreased vascular stiffness. These findings demonstrate that MOTS-c can improve cardiovascular and vascular abnormalities caused by vascular calcification.

SS-31:

https://www.sciencedirect.com/science/article/pii/S0006291X24017649

SS-31 markedly improved the behavioral indices and significantly mitigated the damage to the sciatic nerve

SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop - The Journal of Headache and Pain

Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller peptide (SS-31) is a new mitochondria-targeted tetrapeptide molecule that has been...

link.springer.com

SS-31 has the potential to be an effective drug candidate for headache treatment.

https://journals.sagepub.com/doi/abs/10.1177/03635465221107943

SS-31, as a mitochondrial protectant, could improve mitochondrial function and promote the healing of tendinopathy.

Studies have indicated that SS-31 can improve mitochondrial function in tendon cells and promote the healing process in injured tendons.

GHK-Cu:

https://www.laweekly.com/ghk-cu-potential-and-functions/?utm_source=rss&utm_medium=rss&utm_campaign=ghk-cu-potential-and-functions

Research in animal models has indicated that GHK-Cu may protect diabetic rats from kidney-damaging fibrosis by increasing decorin, an anti-inflammatory proteoglycan.

https://onlinelibrary.wiley.com/doi/full/10.1155/2012/324832

The GHK-Cu peptide should be considered a promising neuroprotective agent capable of preventing the development of common age-associated neurodegenerative disorders.

"Just when I think I know everything that these peptides treat, some other benefit emerges"
~ @amynurse

 

[scarywood75]

And my new favorite Selank IN - now getting some of the best sleep I've had in many years. Sub Q selank semax I wasn't a fan of but the already prepared IN is completely different.

Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?

 

[Valerie]

Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?

Sub q selank and semax were not for me. I didn't have good results. Sub q selank made me tired and irritable; not relaxed and semax jittery. Will effect everyone differently of course.

Nasal selank has been great for sleep with my Epi Dsip sleep stack as well as general anxiety. It's just enough of a dose for me with a relaxing effect.

 

[Peloma]

Selank sub q does work as well? I have some left in my freezer that I tried in nasal spray, didn't do shit.

Do you mean IM, or else what's IN?

They work for me subq. .5 to 1mg is perfect. I took a bigger dose to see what would happen, and I didnt like that feeling. Felt like I had taken xanax.

 

[Valerie]

They work for me subq. .5 to 1mg is perfect. I took a bigger dose to see what would happen, and I didnt like that feeling. Felt like I had taken xanax.

That's great !!

I tried 150-200mcg; very low. Turns out even lower is better for me ... lol 😂 and or maybe it's the direct to blood brain barrier; idk but 1-2 squirts is plenty.

 

[scarywood75]

They work for me subq. .5 to 1mg is perfect. I took a bigger dose to see what would happen, and I didnt like that feeling. Felt like I had taken xanax.

Just selank or semax too?

 

[Peloma]

Just selank or semax too?

Both. Used as needed. I did a week daily alternating am and pm.

 

[AndyPanda]

Just selank or semax too?

I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.

 

[scarywood75]

I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.

Interesting, what effect do you have from it?

 

[AndyPanda]

Interesting, what effect do you have from it?

Improved sleep, and clarity. I don’t know if the clarity is from the sleep or the drug.

 

[Peloma]

I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.

I've heard it can be disappointing for some. Not in my case. I guess I'm sensitive to these. I may hold off on them to see Mots-c on its own.

 

[Rebecca2025]

I’ve tried both of these and was disappointed twice. I think Pinealon is more effective and if you grew up drinking water with fluoride in it, you might need it anyway. It’s also neuro protective.

I have been looking into Pinealon. Have you stacked it with Epitalon?

 

[AndyPanda]

I have been looking into Pinealon. Have you stacked it with Epitalon?

I have not.